LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Danish
Study Design
Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions
Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Identifier
rs2953983
In Other Studies (IDs)
3199
Cytogenetic Location
8p11.21
UCSC Genome Browser
View 8p11.21 on the UCSC genome browser

Gene details

HGNC symbol
POLB
Aliases
 
Common name
DNA polymerase beta 
Description
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Other longevity studies of this gene
3
OMIM
174760
Ensembl
ENSG00000070501
UniProt/Swiss-Prot
B7Z1W5_HUMAN
Entrez Gene
5423
UniGene
654484
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
polb
Mus musculus
Polb
Rattus norvegicus
Polb
Saccharomyces cerevisiae
POL4

In other databases

GenAge human genes
  • This gene is present as POLB

References

Soerensen et al. (2012)

Other variants which are also part of this study