LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Sardinia)
- Study Design
- 129 centenarians and 154 sexagenarians randomly selected from the inhabitants of the same province were examined. In addition, 24 85-year-old sibs of centenarians were enrolled.
- Conclusions
- Sib pair analysis showed nonsignificant differences between the observed and expected percentage of DQA* allele sharing
- Identifier
- HLA-DQA1
- In Other Studies (IDs)
- 196 376
- Cytogenetic Location
- 6p21.32
- UCSC Genome Browser
- View 6p21.32 on the UCSC genome browser
Gene details
- HGNC symbol
- HLA-DQA1
- Aliases
- DQ-A1; CELIAC1; HLA-DQA
- Common name
- major histocompatibility complex, class II, DQ alpha 1
- Description
- HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 4
- OMIM
- 146880
- Ensembl
- ENSG00000196735
- UniProt/Swiss-Prot
- A0A173ADG5_HUMAN
- Entrez Gene
- 3117
- UniGene
- 387679
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- si:busm1-48c11.3
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:busm1-194e12.8
- Danio rerio
- si:zfos-2070c2.1
- Danio rerio
- si:ch73-211l2.3
- Danio rerio
- zgc:123107
- Danio rerio
- si:zfos-367g9.1
- Danio rerio
- CU914776.1
- Danio rerio
- si:busm1-160c18.1
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:busm1-48c11.3
- Danio rerio
- si:zfos-367g9.1
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:busm1-48c11.3
- Danio rerio
- si:busm1-194e12.8
- Danio rerio
- si:zfos-2070c2.1
- Danio rerio
- si:busm1-48c11.3
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:ch73-211l2.3
- Danio rerio
- CU914776.1
- Danio rerio
- si:busm1-266f07.2
- Danio rerio
- si:busm1-160c18.1
- Danio rerio
- zgc:123107
- Mus musculus
- H2-Aa
- Mus musculus
- H2-Aa
- Rattus norvegicus
- RT1-Ba
- Rattus norvegicus
- RT1-Ba