LongevityMap variant
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- HGNC symbol
- STX8
- Aliases
- CARB
- Common name
- syntaxin 8
- Description
- The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
- OMIM
- 604203
- Ensembl
- ENSG00000170310
- UniProt/Swiss-Prot
- STX8_HUMAN
- Entrez Gene
- 9482
- UniGene
- 431109
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- stx8
- Drosophila melanogaster
- Syx8
- Mus musculus
- Stx8
- Rattus norvegicus
- Stx8
Nebel et al. (2011)
Other variants which are also part of this study
