LongevityMap variant
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- Nested case-control design was used in 213 longevity phenotype subjects (80-93 y, 85.6±3.1) and 402 controls (71-79 y, 74.6±2.1) to identify the association between genetic variation in insulin/IGF-1 signaling genes and longevity
- Conclusions
- No association was found between genetic variation in any of the tested genes and longevity in American men of Japanese ancestry
- HGNC symbol
- EXO1
- Aliases
- HEX1; hExoI
- Common name
- exonuclease 1
- Description
- This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 606063
- Ensembl
- ENSG00000174371
- UniProt/Swiss-Prot
- A8K5H6_HUMAN
- Entrez Gene
- 9156
- UniGene
- 498248
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- exo-1
- Danio rerio
- exo1
- Drosophila melanogaster
- tos
- Mus musculus
- Exo1
- Rattus norvegicus
- Exo1
- Saccharomyces cerevisiae
- EXO1
- Saccharomyces cerevisiae
- DIN7
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as EXO1
- CellAge gene expression
- This gene is present as EXO1
Morris et al. (2014)
Other variants which are also part of this study