LongevityMap variant

Entry Details

Longevity Association
Significant
Population
American (Caucasian)
Study Design
T1565C SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females)
Conclusions
The Pl(A2) allele frequency significantly decreased with age
Identifier
T1565C
Cytogenetic Location
17q21.32
UCSC Genome Browser
View 17q21.32 on the UCSC genome browser

Gene details

HGNC symbol
ITGB3
Aliases
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 
Common name
integrin subunit beta 3 
Description
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
1
OMIM
173470
Ensembl
ENSG00000259207
UniProt/Swiss-Prot
ITB3_HUMAN
Entrez Gene
3690
UniGene
218040
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
pat-3
Danio rerio
itgb3b
Drosophila melanogaster
mys
Mus musculus
Itgb3
Rattus norvegicus
Itgb3

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as mys
  • A homolog of this gene for Caenorhabditis elegans is present as pat-3

References

Hessner et al. (2001)

Other variants which are also part of this study