LongevityMap variant
- Longevity Association
- Significant
- Population
- Chinese (Han)
- Study Design
- Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals
- Conclusions
- All 3 SNPs of FOXO3A were associated with longevity in both genders (P = 0.005-0.001)
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo3
- Rattus norvegicus
- Foxo3
- Saccharomyces cerevisiae
- HCM1
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
- GenAge human genes
- This gene is present as FOXO3
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Mus musculus is present as Foxo3
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- CellAge
- This gene is present as FOXO3
Li et al. (2009)
Other variants which are also part of this study