LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Chinese (Han)
Study Design
Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals
Conclusions
All 3 SNPs of FOXO3A were associated with longevity in both genders (P = 0.005-0.001)
Identifier
rs4946936
In Other Studies (IDs)
1683
Cytogenetic Location
6q21
UCSC Genome Browser
View 6q21 on the UCSC genome browser

Gene details

HGNC symbol
FOXO3
Aliases
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 
Common name
forkhead box O3 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
101
OMIM
602681
Ensembl
ENSG00000118689
UniProt/Swiss-Prot
FOXO3_HUMAN
Entrez Gene
2309
UniGene
220950
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
daf-16
Danio rerio
foxo3a
Danio rerio
foxo3b
Drosophila melanogaster
foxo
Mus musculus
Foxo3
Rattus norvegicus
Foxo3
Saccharomyces cerevisiae
HCM1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
GenAge human genes
  • This gene is present as FOXO3
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Mus musculus is present as Foxo3
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
CellAge
  • This gene is present as FOXO3

References

Li et al. (2009)

Other variants which are also part of this study