LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- A/V114 SNP was examined in 187 unselected centenarians, and 201 healthy controls aged 20-64 years (mean age 42 years)
- Conclusions
- No significant association with longevity was found
- HGNC symbol
- MTHFR
- Aliases
-
- Common name
- methylenetetrahydrofolate reductase
- Description
- The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 16
- OMIM
- 607093
- Ensembl
- ENSG00000177000
- UniProt/Swiss-Prot
- MTHR_HUMAN
- Entrez Gene
- 4524
- UniGene
- 214142
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- C06A8.1
- Danio rerio
- mthfr
- Mus musculus
- Mthfr
- Rattus norvegicus
- Mthfr
- Saccharomyces cerevisiae
- MET13
- Schizosaccharomyces pombe
- met9
Bladbjerg et al. (1999)
Other variants which are also part of this study
