LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Italian (Northern)
Study Design
GSTT1 (Glutathione S-transferase theta 1) deletion and the simultaneous presence of the three p53 polymorphisms were examined in 66 nonagenarians and centenarians in good health and in a sample of 150 young healthy volunteers of the same ethnic group
Conclusions
No significant differences were found for individual genes. However, the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (41.5% versus 26.9% and 8.8% versus 3.8%, respectively).
Identifier
GSTT1
In Other Studies (IDs)
50 148 212
Cytogenetic Location
22q11.23
UCSC Genome Browser
View 22q11.23 on the UCSC genome browser

Gene details

HGNC symbol
GSTT1
Aliases
 
Common name
glutathione S-transferase theta 1 
Description
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Other longevity studies of this gene
3
OMIM
600436
Ensembl
UniProt/Swiss-Prot
A0A0G2JRN4_HUMAN
Entrez Gene
2952
UniGene
268573
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
gstt1b
Mus musculus
Gstt1
Rattus norvegicus
Gstt1

References

Gaspari et al. (2003)

Other variants which are also part of this study