LongevityMap variant
- Longevity Association
- Significant
- Population
- Russian
- Study Design
- 510 subjects were analyzed for the genotype distribution of CASP5 Ala90Thr polymorphism.
- Conclusions
- Heterozygosity for CASP5 Ala90Thr polymorphism was negatively associated with life expectancy.
- HGNC symbol
- CASP5
- Aliases
- ICH-3; ICEREL-III; ICE(rel)III
- Common name
- caspase 5
- Description
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
- OMIM
- 602665
- Ensembl
- ENSG00000137757
- UniProt/Swiss-Prot
- CASP5_HUMAN
- Entrez Gene
- 838
- UniGene
- 213327
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- csp-2
- Caenorhabditis elegans
- ced-3
- Caenorhabditis elegans
- csp-3
- Caenorhabditis elegans
- csp-1
- Danio rerio
- zgc:171731
- Danio rerio
- caspa
- Danio rerio
- caspbl
- Danio rerio
- caspb
- Drosophila melanogaster
- Dronc
- Mus musculus
- Casp4
- Rattus norvegicus
- Casp4
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ced-3
- A homolog of this gene for Caenorhabditis elegans is present as csp-2
Ulybina et al. (2010)
Other variants which are also part of this study