LongevityMap variant
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years)
- Conclusions
- The Hinf347 genotype distribution was significantly different in centenarians
- HGNC symbol
- APOA4
- Aliases
-
- Common name
- apolipoprotein A4
- Description
- Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 107690
- Ensembl
- ENSG00000110244
- UniProt/Swiss-Prot
- Entrez Gene
- 337
- UniGene
- 1247
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- apoa4b.2
- Danio rerio
- apoa4b.3
- Danio rerio
- apoa4a
- Danio rerio
- apoa4b.1
- Mus musculus
- Apoa4
- Rattus norvegicus
- Apoa4
Pepe et al. (1998)
Other variants which are also part of this study
