LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Spanish
Study Design: Three polymorphisms in inflammation-related genes RANTES and CCR5 were studied in 104 elderly and 110 controls
Conclusions: CCR5 polymorphism rs333 was not significantly different between elderly and controls

HGNC symbol: CCR5
Aliases: CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5
Common name: C-C motif chemokine receptor 5 (gene/pseudogene)
Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
OMIM: 601373
Ensembl: ENSG00000160791
UniProt/Swiss-Prot: CCR5_HUMAN
Entrez Gene: 1234
UniGene: 450802
HapMap: View on HapMap