LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Italian
Study Design
Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions
Of 67 SNPs identified with an indication of potentially being associated with longevity (p < 1 × 10−4), rs10491334 (in CAMKIV) was further tested in the independent population and a significant association found
Identifier
rs10491334
Cytogenetic Location
5q22.1
UCSC Genome Browser
View 5q22.1 on the UCSC genome browser

Gene details

HGNC symbol
CAMK4
Aliases
caMK; CaMK; IV; CaMK-GR 
Common name
calcium/calmodulin dependent protein kinase IV 
Description
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
OMIM
114080
Ensembl
ENSG00000152495
UniProt/Swiss-Prot
KCC4_HUMAN
Entrez Gene
814
UniGene
438801
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
camk4
Mus musculus
Camk4
Rattus norvegicus
Camk4
Saccharomyces cerevisiae
CMK2

References

Malovini et al. (2011)

Other variants which are also part of this study