LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Danish
Study Design
592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions
The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
Identifier
rs2953983
In Other Studies (IDs)
267
Cytogenetic Location
8p11.21
UCSC Genome Browser
View 8p11.21 on the UCSC genome browser

Gene details

HGNC symbol
POLB
Aliases
 
Common name
DNA polymerase beta 
Description
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Other longevity studies of this gene
3
OMIM
174760
Ensembl
ENSG00000070501
UniProt/Swiss-Prot
B7Z1W5_HUMAN
Entrez Gene
5423
UniGene
654484
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
polb
Mus musculus
Polb
Rattus norvegicus
Polb
Saccharomyces cerevisiae
POL4

In other databases

GenAge human genes
  • This gene is present as POLB

References

Debrabant et al. (2014)

Other variants which are also part of this study