LongevityMap variant

Entry Details

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
Conclusions
A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
Identifier
rs2826891
Cytogenetic Location
21q21.1
UCSC Genome Browser
View 21q21.1 on the UCSC genome browser

Gene details

HGNC symbol
NCAM2
Aliases
NCAM21 
Common name
neural cell adhesion molecule 2 
Description
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
OMIM
602040
Ensembl
ENSG00000154654
UniProt/Swiss-Prot
NCAM2_HUMAN
Entrez Gene
4685
UniGene
473450
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
zgc:152904
Mus musculus
Ncam2
Rattus norvegicus
Ncam2

References

Yashin et al. (2012)

Other variants which are also part of this study