LongevityMap variant

Entry Details

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
Conclusions
A total of 27 SNPs were identified at the intersection of various statistical procedures
Identifier
rs9876781
Cytogenetic Location
3p21.31
UCSC Genome Browser
View 3p21.31 on the UCSC genome browser

Gene details

HGNC symbol
ATRIP
Aliases
 
Common name
ATR interacting protein 
Description
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
OMIM
606605
Ensembl
ENSG00000164053
UniProt/Swiss-Prot
A0A024R2U4_HUMAN
Entrez Gene
84126
UniGene
694840
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
atrip
Mus musculus
Atrip
Rattus norvegicus
LOC100911807

References

Yashin et al. (2012)

Other variants which are also part of this study