LongevityMap variant

Entry Details

Longevity Association: Significant
Population: American (Caucasian)
Study Design: 224 nonagenarian cases (84 male, 140 female, 90- 103 y) and 293 young controls (100 male, 193 female, 21- 59 y) from the Louisiana Healthy Aging Study were examined for longevity association study. Then, 170 subjects(25 male, 145 female, ≥98 y) and 220 young controls (84 male, 136 female, 20–59 y) from the Georgia Centenarian Study were examined to replicate the results.
Conclusions: rs7896005 in SIRT1 had significant effects on telomere length and was significantly associated with longevity (P < 0.003). rs7896005 association persisted independently of rs132793.

HGNC symbol: SIRT1
Aliases: SIR2; SIR2L1; SIR2alpha
Common name: sirtuin 1
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Other longevity studies of this gene: 33
OMIM: 604479
Ensembl: ENSG00000096717
UniProt/Swiss-Prot: A0A024QZQ1_HUMAN
Entrez Gene: 23411
UniGene: 369779
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

CellAge

Kim et al. (2012)