LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- 11 SNPs within the SDC4 gene were tested for association with longevity in a cohort of 624 unrelated subjects (aged 64-107, 287 males and 337 females, 350 subjects > 85 years old). Then the identified longevity-associated SNPs were correlated with metabolic parameters in the subgroup of 64-85 years old.
- Conclusions
- After multiple test correction, those 9 SNPs were not associated with longevity or other metabolic parameters.
- HGNC symbol
- SDC4
- Aliases
- SYND4
- Common name
- syndecan 4
- Description
- The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 9
- OMIM
- 600017
- Ensembl
- ENSG00000124145
- UniProt/Swiss-Prot
- B4E1S6_HUMAN
- Entrez Gene
- 6385
- UniGene
- 632267
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sdn-1
- Danio rerio
- sdc4
- Drosophila melanogaster
- Sdc
- Mus musculus
- Sdc4
- Rattus norvegicus
- Sdc4
- GenAge microarray genes
- This gene is present as SDC4
Rose et al. (2015)
Other variants which are also part of this study
