LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- The variability of the three human genes (NOS1, NOS2, NOS3) was studied in a large sample (763 subjects, age range 19–107 years, median age 81 years). The sample analyzed included 417 females and 346 males.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1879417, showed a significant association with the longevity phenotype. The NOS2 rs2297518 SNP was only marginally associated with longevity.
- HGNC symbol
- NOS3
- Aliases
- eNOS; ECNOS
- Common name
- nitric oxide synthase 3
- Description
- Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- Other longevity studies of this gene
- 13
- OMIM
- 163729
- Ensembl
- ENSG00000164867
- UniProt/Swiss-Prot
- A0A0A0MTA6_HUMAN
- Entrez Gene
- 4846
- UniGene
- 647092
- HapMap
- View on HapMap
Homologs in model organisms
- Drosophila melanogaster
- Nos
- Mus musculus
- Nos3
- Rattus norvegicus
- Nos3
- Saccharomyces cerevisiae
- NCP1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Nos3
Montesanto et al. (2013)
Other variants which are also part of this study
