LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Italian (Sardinia)
Study Design
112 (36 male, 76 female) centenarians, as well as 137 sixty-year-old controls, were analyzed for 874T/A SNP
Conclusions
No significant differences were observed between centenarians and controls
Identifier
874T/A
In Other Studies (IDs)
79 137 372
Cytogenetic Location
12q15
UCSC Genome Browser
View 12q15 on the UCSC genome browser

Gene details

HGNC symbol
IFNG
Aliases
IFG; IFI 
Common name
interferon gamma 
Description
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Other longevity studies of this gene
5
OMIM
147570
Ensembl
ENSG00000111537
UniProt/Swiss-Prot
IFNG_HUMAN
Entrez Gene
3458
UniGene
856
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Ifng
Rattus norvegicus
Ifng

In other databases

CellAge
  • This gene is present as IFNG

References

Pes et al. (2004)

Other variants which are also part of this study