Gene ID Entrez Gene ID Gene Symbol Gene Name Organism Unigene ID Ensembl ID UniProt ID Alias Lifespan Effect Phenotype Description Longevity Influence Max Lifespan Change Avg Lifespan Change Method Bibliographic reference 1553 852380 AAC3 ADP/ATP Carrier Saccharomyces cerevisiae YBR085W ANC3 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1393 855581 AAH1 Adenine AminoHydrolase Saccharomyces cerevisiae YNL141W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1612 853755 AAT1 Aspartate AminoTransferase Saccharomyces cerevisiae YKL106W increase Replicative lifespan increased by 25% pro 25 Overexpression 2511: Easlon et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944 (18381895) 1613 850714 AAT2 Aspartate AminoTransferase Saccharomyces cerevisiae YLR027C ASP5 increase Replicative lifespan increased by 15% pro 15 Overexpression 2511: Easlon et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944 (18381895) 1683 850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae YCR088W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1683 850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae YCR088W decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1683 850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae YCR088W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1683 850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae YCR088W decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1507 852925 ACB1 Acyl-CoA-Binding Saccharomyces cerevisiae YGR037C increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1914 852266 ACH1 Ach1p Saccharomyces cerevisiae decrease Deletion of ACH1 reduces chronological lifespan. fitness Deletion 3522: Eisenberg et al. (2014) "Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan." Cell Metab. 19(3):431-444 (24606900) 1648 853230 ACO2 ACOnitase Saccharomyces cerevisiae YJL200C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1648 853230 ACO2 ACOnitase Saccharomyces cerevisiae YJL200C decrease Replicative lifespan decreased by 10% in the a strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1600 850846 ACS2 Acetyl CoA Synthetase Saccharomyces cerevisiae YLR153C decrease Replicative lifespan decreased by 70% in the alpha strain pro 70 Deletion 2509: Falcón et al. (2010) "Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae." Mol. Cell. Biochem. 333(1-2):99-9108 (19618123) 1299 852059 ADA2 transcriptional ADAptor Saccharomyces cerevisiae YDR448W SWI8 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1299 852059 ADA2 transcriptional ADAptor Saccharomyces cerevisiae YDR448W SWI8 decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1016 855222 ADD37 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae YMR184W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1016 855222 ADD37 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae YMR184W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1017 853629 ADD66 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae YKL206C PBA2 POC2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1332 851272 ADE1 ADEnine requiring Saccharomyces cerevisiae YAR015W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1333 855501 ADE12 ADEnine requiring Saccharomyces cerevisiae YNL220W BRA9 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1209 855149 ADE17 ADEnine requiring Saccharomyces cerevisiae YMR120C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1334 854295 ADE2 ADEnine requiring Saccharomyces cerevisiae YOR128C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1018 853118 ADE3 ADEnine requiring Saccharomyces cerevisiae YGR204W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1018 853118 ADE3 ADEnine requiring Saccharomyces cerevisiae YGR204W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1335 855346 ADE4 ADEnine requiring Saccharomyces cerevisiae YMR300C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1336 852617 ADE5,7 ADEnine requiring Saccharomyces cerevisiae YGL234W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1336 852617 ADE5,7 ADEnine requiring Saccharomyces cerevisiae YGL234W no change Deletion of ADE5,7 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1337 852952 ADE6 ADEnine requiring Saccharomyces cerevisiae YGR061C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1649 854068 ADH1 Alcohol DeHydrogenase Saccharomyces cerevisiae YOL086C ADC1 increase Replicative lifespan increased by 20% in the alpha strain and 15% in the a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1019 855349 ADH2 Alcohol DeHydrogenase Saccharomyces cerevisiae YMR303C ADR2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1019 855349 ADH2 Alcohol DeHydrogenase Saccharomyces cerevisiae YMR303C ADR2 increase Knockout of ADH2 results in an extended chronological median lifespan. anti 60 Knockout 3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (24153335) 1210 851812 ADK1 ADenylate Kinase Saccharomyces cerevisiae YDR226W AKY1 AKY2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1576 851802 ADR1 Alcohol Dehydrogenase Regulator Saccharomyces cerevisiae YDR216W decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1020 855086 AEP1 ATPase ExPression Saccharomyces cerevisiae YMR064W NCA1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1020 855086 AEP1 ATPase ExPression Saccharomyces cerevisiae YMR064W NCA1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1020 855086 AEP1 ATPase ExPression Saccharomyces cerevisiae YMR064W NCA1 increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 30 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1650 856737 AFG3 ATPase Family Gene Saccharomyces cerevisiae YER017C YTA10 increase Replicative lifespan increased by 20% in the alpha and a strains anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1524 856132 AGC1 Aspartate-Glutamate Carrier Saccharomyces cerevisiae YPR021C increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 8 850333 AGP1 high-Affinity Glutamine Permease Saccharomyces cerevisiae YCL025C YCC5 increase Deletion extends chronological lifespan. anti Deletion 2238: Powers et al. (2006) "Extension of chronological life span in yeast by decreased TOR pathway signaling." Genes Dev. 20(2):174-184 (16418483) 1021 853543 AIM24 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae YJR080C FMP26 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1211 855189 AIM36 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae YMR157C FMP39 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1452 852351 AKL1 Ark family Kinase-Like protein Saccharomyces cerevisiae YBR059C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1471 851857 AKR1 AnKyrin Repeat-containing protein Saccharomyces cerevisiae YDR264C decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1471 851857 AKR1 AnKyrin Repeat-containing protein Saccharomyces cerevisiae YDR264C decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1300 855205 ALD3 ALdehyde Dehydrogenase Saccharomyces cerevisiae YMR169C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1570 854556 ALD4 ALdehyde Dehydrogenase Saccharomyces cerevisiae YOR374W ALD7 increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1885 856044 ALD6 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae ALD1 increase Deletion of ALD6 increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1698 855764 ALG12 Asparagine-Linked Glycosylation Saccharomyces cerevisiae YNR030W ECM39 increase Replicative lifespan increased by 25% in both the alpha strain and the a strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1698 855764 ALG12 Asparagine-Linked Glycosylation Saccharomyces cerevisiae YNR030W ECM39 increase Deletion of alg12, a target of the unfolded protein response signaling, increases replicative lifespan. This increase is dependant on Ire1p, a functional ER stress sensor protein. anti 16 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1867 852196 ALG3 dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Saccharomyces cerevisiae RHK1 increase Deletion of alg3, a target of the unfolded protein response signaling, increases replicative lifespan. anti 10 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1531 855874 ALG5 Asparagine-Linked Glycosylation Saccharomyces cerevisiae YPL227C increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 2137 854163 ALG6 dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Saccharomyces cerevisiae increase Deletion of ALG6 in yeast increased mean replicative lifespan. anti 15 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1357 851690 ALT2 ALanine Transaminase Saccharomyces cerevisiae YDR111C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1338 854973 AMD1 AMP Deaminase Saccharomyces cerevisiae YML035C AMD3 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1022 852455 AMN1 Antagonist of Mitotic exit Network Saccharomyces cerevisiae YBR158W CST13 ICS4 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1484 856527 ANS1 Ans1p Saccharomyces cerevisiae YHR126C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 2075 3640787 APC10 potential anaphase-promoting complex processivity factor Apc10 Saccharomyces cerevisiae decrease Deletion of APC10 results in a drecreased lifespan. pro Deletion 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 2075 3640787 APC10 potential anaphase-promoting complex processivity factor Apc10 Saccharomyces cerevisiae increase Overexpression of APC10 increases maximum lifespan by over 50%. pro 50 Overexpression 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 2076 854423 APC5 anaphase promoting complex subunit 5 Saccharomyces cerevisiae RMC1 decrease APC mutants display a decreased lifespan. pro Mutation 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 2076 854423 APC5 anaphase promoting complex subunit 5 Saccharomyces cerevisiae RMC1 decrease Overexpression of APC5 decreases lifespan. anti Overexpression 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 2074 850792 APC9 anaphase promoting complex subunit 9 Saccharomyces cerevisiae decrease Deletion of APC9 results in a drecreased lifespan. pro Deletion 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 1212 852589 APE3 AminoPEptidase Saccharomyces cerevisiae YBR286W APY1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1485 853723 APL2 clathrin Adaptor Protein complex Large chain Saccharomyces cerevisiae YKL135C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1358 855869 APM1 clathrin Adaptor Protein complex Medium chain Saccharomyces cerevisiae YPL259C YAP54 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1339 854986 APT1 Adenine PhosphoribosylTransferase Saccharomyces cerevisiae YML022W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1890 855660 AQR1 Aqr1p Saccharomyces cerevisiae Deletion of AQR1 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1301 856404 ARD1 ARrest Defective Saccharomyces cerevisiae YHR013C NAA10 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1359 851335 ARF1 ADP-Ribosylation Factor Saccharomyces cerevisiae YDL192W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1023 853374 ARG2 ARGinine requiring Saccharomyces cerevisiae YJL071W HRB574 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1651 855711 ARK1 Actin Regulating Kinase Saccharomyces cerevisiae YNL020C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1651 855711 ARK1 Actin Regulating Kinase Saccharomyces cerevisiae YNL020C decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1024 856173 ARO7 AROmatic amino acid requiring Saccharomyces cerevisiae YPR060C HGS1 OSM2 TYR7 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1486 856530 ARP1 Actin-Related Protein Saccharomyces cerevisiae YHR129C ACT5 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1486 856530 ARP1 Actin-Related Protein Saccharomyces cerevisiae YHR129C ACT5 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1699 853327 ASF1 Anti-Silencing Function Saccharomyces cerevisiae YJL115W CIA1 decrease Replicative lifespan decreased by 65% in the alpha strain fitness 65 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1699 853327 ASF1 Anti-Silencing Function Saccharomyces cerevisiae YJL115W CIA1 decrease Yeast lacking Asf1 are short lived, having a median replicative life span of about 7 generations in comparison to the median life span of about 27 generations for wild-type yeast in multiple yeast backgrounds. Asf1 mutants also exhibit some phenotypes characteristic of aging. fitness 74 Deletion 1025 854676 ASG1 Activator of Stress Genes Saccharomyces cerevisiae YIL130W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1413 852695 ATG1 AuTophaGy related Saccharomyces cerevisiae YGL180W APG1 AUT3 CVT10 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1413 852695 ATG1 AuTophaGy related Saccharomyces cerevisiae YGL180W APG1 AUT3 CVT10 decrease Reduced chronological lifespan by 70% fitness 70 Deletion 2515: Alvers et al. (2009) "Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae." Aging Cell 8(4):353-369 (19302372) 1213 850684 ATG10 AuTophaGy related Saccharomyces cerevisiae YLL042C APG10 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1302 852518 ATG12 AuTophaGy related Saccharomyces cerevisiae YBR217W APG12 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1214 856315 ATG13 AuTophaGy related Saccharomyces cerevisiae YPR185W APG13 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1215 852425 ATG14 AuTophaGy related Saccharomyces cerevisiae YBR128C APG14 CVT12 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1026 850432 ATG15 AuTophaGy related Saccharomyces cerevisiae YCR068W AUT5 CVT17 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1026 850432 ATG15 AuTophaGy related Saccharomyces cerevisiae YCR068W AUT5 CVT17 decrease Replicative lifespan decreased by 40% on CR medium fitness 40 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1303 855194 ATG16 AuTophaGy related Saccharomyces cerevisiae YMR159C APG15 APG16 CVT11 SAP18 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1664 851142 ATG17 AuTophaGy related Saccharomyces cerevisiae YLR423C APG17 decrease Replicative lifespan decreased by 70% on CR medium fitness 70 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1304 850577 ATG18 AuTophaGy related Saccharomyces cerevisiae YFR021W AUT10 CVT18 NMR1 SVP1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1304 850577 ATG18 AuTophaGy related Saccharomyces cerevisiae YFR021W AUT10 CVT18 NMR1 SVP1 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1216 855479 ATG2 AuTophaGy related Saccharomyces cerevisiae YNL242W APG2 AUT8 SPO72 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1027 856004 ATG21 AuTophaGy related Saccharomyces cerevisiae YPL100W HSV1 MAI1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1217 855937 ATG29 AuTophaGy related Saccharomyces cerevisiae YPL166W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1305 855954 ATG5 AuTophaGy related Saccharomyces cerevisiae YPL149W APG5 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1218 856576 ATG7 AuTophaGy related Saccharomyces cerevisiae YHR171W APG11 APG7 CVT2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1218 856576 ATG7 AuTophaGy related Saccharomyces cerevisiae YHR171W APG11 APG7 CVT2 decrease Reduced chronological lifespan by 70% fitness 70 Deletion 2515: Alvers et al. (2009) "Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae." Aging Cell 8(4):353-369 (19302372) 1306 852200 ATG8 AuTophaGy related Saccharomyces cerevisiae YBL078C APG8 AUT7 CVT5 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1219 851406 ATG9 AuTophaGy related Saccharomyces cerevisiae YDL149W APG9 AUT9 CVT7 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1028 856137 ATH1 Acid TreHalase Saccharomyces cerevisiae YPR026W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1604 852177 ATP1 ATP synthase Saccharomyces cerevisiae YBL099W decrease Replicative lifespan decreased by 70% in the alpha strain fitness 70 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1604 852177 ATP1 ATP synthase Saccharomyces cerevisiae YBL099W increase Chronological lifespan increased up to 50% anti 50 Deletion 2516: Francis et al. (2007) "Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae." J. Bioenerg. Biomembr. 39(2):127-144 (17492370) 1487 854893 ATP18 ATP synthase Saccharomyces cerevisiae YML081C-A decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 29 853585 ATP2 ATP synthase F1 subunit gamma Saccharomyces cerevisiae YJR121W decrease A mutation causes a clonal senescence phenotype resulting from the disruption of the age asymmetry between mother and daughter cells in that that daughter cells are born old. pro Mutation 2245: Lai et al. (2002) "A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae." Genetics 162(1):73-87 (12242224) 29 853585 ATP2 ATP synthase F1 subunit gamma Saccharomyces cerevisiae YJR121W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1640 852327 ATP3 ATP synthase Saccharomyces cerevisiae YBR039W increase Chronological lifespan increased up to 50% anti 50 Deletion 2516: Francis et al. (2007) "Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae." J. Bioenerg. Biomembr. 39(2):127-144 (17492370) 1652 856027 ATP4 ATP synthase Saccharomyces cerevisiae YPL078C LPF7 decrease Replicative lifespan decreased by 10% in the alpha strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1029 853457 AVT1 Amino acid Vacuolar Transport Saccharomyces cerevisiae YJR001W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1030 852360 BAP2 Branched-chain Amino acid Permease Saccharomyces cerevisiae YBR068C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1340 853974 BAS1 BASal Saccharomyces cerevisiae YKR099W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1340 853974 BAS1 BASal Saccharomyces cerevisiae YKR099W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1340 853974 BAS1 BASal Saccharomyces cerevisiae YKR099W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1031 853350 BCK1 Bypass of C Kinase Saccharomyces cerevisiae YJL095W LAS3 SAP3 SLK1 SSP31 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1031 853350 BCK1 Bypass of C Kinase Saccharomyces cerevisiae YJL095W LAS3 SAP3 SLK1 SSP31 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1032 851981 BCS1 ubiquinol-cytochrome c reductase (bc1) Synthesis Saccharomyces cerevisiae YDR375C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 42 854778 BCY1 Bypass of CYclase mutations Saccharomyces cerevisiae YIL033C SRA1 decrease Deletion of BCY1 results in a decrease in lifespan. fitness Deletion 2249: D'mello et al. (1994) "Cloning and characterization of LAG1, a longevity-assurance gene in yeast." J. Biol. Chem. 269(22):15451-15459 (8195187) 42 854778 BCY1 Bypass of CYclase mutations Saccharomyces cerevisiae YIL033C SRA1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1680 852499 BEM1 Bud EMergence Saccharomyces cerevisiae YBR200W SRO1 decrease Replicative lifespan decreased by 75% in the alpha strain fitness 75 Deletion 2527: Liu et al. (2010) "The polarisome is required for segregation and retrograde transport of protein aggregates." Cell 140(2):257-267 (20141839) 1668 853551 BIR1 Baculoviral IAP Repeat-containing protein Saccharomyces cerevisiae YJR089W increase Increased chronological lifespan pro Overexpression 2517: Walter et al. (2006) "The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2." J. Cell. Sci. 119(Pt 9):1843-1851 (16608876) 1033 856924 BMH1 Brain Modulosignalin Homologue Saccharomyces cerevisiae YER177W APR6 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1033 856924 BMH1 Brain Modulosignalin Homologue Saccharomyces cerevisiae YER177W APR6 increase Extends chronological life span (CLS) by activating stress response pro Overexpression 2518: Wang et al. (2009) "Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response." Genetics 183(4):1373-1384 (19805817) 1033 856924 BMH1 Brain Modulosignalin Homologue Saccharomyces cerevisiae YER177W APR6 increase Extends chronological lifespan by 25% by activating stress response anti 25 Deletion 2518: Wang et al. (2009) "Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response." Genetics 183(4):1373-1384 (19805817) 1670 851676 BMH2 Brain Modulosignalin Homologue Saccharomyces cerevisiae YDR099W SCD3 increase Extends chronological life span (CLS) by activating stress response pro Overexpression 2518: Wang et al. (2009) "Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response." Genetics 183(4):1373-1384 (19805817) 1341 853541 BNA2 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae YJR078W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1611 850608 BNA6 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae YFR047C QPT1 decrease Chronological lifespan decreased pro Deletion 2510: Tahara et al. (2007) "Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging." FASEB J. 21(1):274-283 (17110466) 1681 855450 BNI1 Bud Neck Involved Saccharomyces cerevisiae YNL271C PPF3 SHE5 decrease Deletion decreased replicative lifespan of the alpha-strain by 65% fitness 65 Deletion 2527: Liu et al. (2010) "The polarisome is required for segregation and retrograde transport of protein aggregates." Cell 140(2):257-267 (20141839) 1541 856850 BOI2 Bem1 (One) Interacting protein Saccharomyces cerevisiae YER114C BEB1 increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1220 850398 BPH1 Beige Protein Homolog Saccharomyces cerevisiae YCR032W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1453 850645 BPT1 Bile Pigment Transporter Saccharomyces cerevisiae YLL015W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 49 855787 BRE5 Bre5p Saccharomyces cerevisiae YNR051C increase Deletion increased mean replicative lifespan by 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 49 855787 BRE5 Bre5p Saccharomyces cerevisiae YNR051C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1454 851524 BSC1 Bypass of Stop Codon Saccharomyces cerevisiae YDL037C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1445 851868 BSC2 Bypass of Stop Codon Saccharomyces cerevisiae YDR275W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1869 850519 BST1 Bst1p Saccharomyces cerevisiae PER17 increase Deletion of bst1, a target of the unfolded protein response signaling, increases replicative lifespan. This increase is dependant on Ire1p, a functional ER stress sensor protein. anti 25 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1697 851029 BUD6 BUD site selection Saccharomyces cerevisiae YLR319C AIP3 Early buds have increased lifespan while 8th and 12th generation daughters have decreased lifespans Deletion 2530: Shcheprova et al. (2008) "A mechanism for asymmetric segregation of age during yeast budding." Nature 454(7205):728-734 (18660802) 1700 851459 BUG1 Binder of USO1 and GRH1 Saccharomyces cerevisiae YDL099W increase Replicative lifespan increased by 50% in the alpha strain anti 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1700 851459 BUG1 Binder of USO1 and GRH1 Saccharomyces cerevisiae YDL099W decrease Replicative lifespan decreased by 50% in the a strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 2064 854929 BUL2 ubiquitin-ubiquitin ligase BUL2 Saccharomyces cerevisiae increase Allele replacement for BUL2 results in a 16% lifespan extension. 16 Allele replacement 3574: Kwan et al. (2011) "Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast." PLoS Genet. 7(8):e1002250 (21901113) 1034 856772 CAJ1 Caj1p Saccharomyces cerevisiae YER048C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2224 856646 CAN1 arginine permease CAN1 Saccharomyces cerevisiae increase Deletion of CAN1 in yeast increased mean replicative lifespan by 30%. This increase was dependent on the Gcn4 and Hac1 transcription factors and reduced mTOR signalling. anti 30 Deletion 4766: Beaupere et al. (2017) "CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes." Cell Rep 18(8):1884-1892 (28228255) 1436 854292 CAT5 CATabolite repression Saccharomyces cerevisiae YOR125C COQ7 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1436 854292 CAT5 CATabolite repression Saccharomyces cerevisiae YOR125C COQ7 decrease Chronological lifespan decreased up to 50% fitness 50 Deletion 2516: Francis et al. (2007) "Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae." J. Bioenerg. Biomembr. 39(2):127-144 (17492370) 1221 856347 CBP2 Cytochrome B mRNA Processing Saccharomyces cerevisiae YHL038C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1035 853085 CBP4 Cytochrome B mRNA Processing Saccharomyces cerevisiae YGR174C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1837 852417 CBP6 Cbp6p Saccharomyces cerevisiae increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 25 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1835 851491 CBS1 Cbs1p Saccharomyces cerevisiae increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 35 20 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1835 851491 CBS1 Cbs1p Saccharomyces cerevisiae increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 37 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 98 855054 CCS1 Ccs1p Saccharomyces cerevisiae YMR038C LYS7 decrease Deletion reduced replicative lifespan by 50%. fitness 50 Deletion 2257: Unlu and Koc (2007) "Effects of deleting mitochondrial antioxidant genes on life span." Ann. N. Y. Acad. Sci. 1100:505-509 (17460215) 1695 851306 CDC13 Cell Division Cycle Saccharomyces cerevisiae YDL220C EST4 decrease Decreased replicative lifespan pro Deletion 2529: Nugent et al. (1996) "Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance." Science 274(5285):249-252 (8824190) 105 851019 CDC25 Cdc25p Saccharomyces cerevisiae YLR310C CTN1 increase Knockout mutants live about 50% longer than controls. anti 50 Knockout 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 2073 850597 CDC26 anaphase promoting complex subunit CDC26 Saccharomyces cerevisiae HIT3 SCD26 decrease Deletion of CDC26 results in a drecreased lifespan. pro Deletion 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 106 853244 CDC6 Cell Division Cycle Saccharomyces cerevisiae YJL194W increase Approximately 20% increase in mean lifespan in knockouts. anti 20 Knockout 2261: Sinclair and Guarente (1997) "Extrachromosomal rDNA circles--a cause of aging in yeast." Cell 91(7):1033-1042 (9428525) 1629 852881 CDH1 CDC20 Homolog Saccharomyces cerevisiae YGL003C HCT1 decrease Replicative lifespan decreased by 45% in the alpha strain fitness 45 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1360 856911 CHD1 Chromatin organization modifier, Helicase, and DNA-binding domains Saccharomyces cerevisiae YER164W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1360 856911 CHD1 Chromatin organization modifier, Helicase, and DNA-binding domains Saccharomyces cerevisiae YER164W increase Deletion of CHD1 in yeast extends replicative lifespan by 14%. anti 14 Deletion 3477: Dang et al. (2014) "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response." Cell Metab. 19(6):952-966 (24814484) 126 856099 CHL1 Chl1p Saccharomyces cerevisiae YPL008W CTF1 LPA9 MCM12 decrease It may modulate transcriptional silencing in the presence of Sir proteins. Knockouts exhibit a shortened lifespan and are hypersensitivity to heat stress. fitness Knockout 2266: Das and Sinha (2005) "The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging." Biochem. Biophys. Res. Commun. 337(1):167-172 (16182251) 126 856099 CHL1 Chl1p Saccharomyces cerevisiae YPL008W CTF1 LPA9 MCM12 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1036 855732 CIT1 CITrate synthase Saccharomyces cerevisiae YNR001C LYS6 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1307 850361 CIT2 CITrate synthase Saccharomyces cerevisiae YCR005C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1508 854227 CKA2 Casein Kinase Alpha' subunit Saccharomyces cerevisiae YOR061W YOR29-12 increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1542 855418 CLA4 CLn Activity dependant Saccharomyces cerevisiae YNL298W ERC10 decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1542 855418 CLA4 CLn Activity dependant Saccharomyces cerevisiae YNL298W ERC10 decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1361 853002 CLB1 CycLin B Saccharomyces cerevisiae YGR108W SCB1 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1361 853002 CLB1 CycLin B Saccharomyces cerevisiae YGR108W SCB1 decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1037 856236 CLB2 CycLin B Saccharomyces cerevisiae YPR119W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1037 856236 CLB2 CycLin B Saccharomyces cerevisiae YPR119W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1038 852657 CLG1 Cyclin-Like Gene Saccharomyces cerevisiae YGL215W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 132 851191 CLN3 Cln3p Saccharomyces cerevisiae YAL040C DAF1 FUN10 WHI1 decrease Overexpression shortens chronological lifespan together with age-dependent increases in genome instability and apoptosis. anti Overexpression 2267: Weinberger et al. (2007) "DNA replication stress is a determinant of chronological lifespan in budding yeast." PLoS ONE 2(8):e748 (17710147) 1201 855287 COA6 Cytochrome Oxidase Assembly Saccharomyces cerevisiae YMR244C-A decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1039 852288 COQ1 COenzyme Q Saccharomyces cerevisiae YBR003W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1222 854154 COQ10 COenzyme Q Saccharomyces cerevisiae YOL008W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1040 854057 COQ3 COenzyme Q Saccharomyces cerevisiae YOL096C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1041 854930 COQ5 COenzyme Q Saccharomyces cerevisiae YML110C DBI56 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1041 854930 COQ5 COenzyme Q Saccharomyces cerevisiae YML110C DBI56 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1223 852235 COR1 CORe protein of QH2 cytochrome c reductase Saccharomyces cerevisiae YBL045C QCR1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1042 855971 COX11 Cytochrome c OXidase Saccharomyces cerevisiae YPL132W LPI13 PSO7 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1472 856516 COX23 Cytochrome OXidase Saccharomyces cerevisiae YHR116W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1043 853267 CPS1 CarboxyPeptidase yscS Saccharomyces cerevisiae YJL172W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1543 854267 CRC1 CaRnitine Carrier Saccharomyces cerevisiae YOR100C increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1543 854267 CRC1 CaRnitine Carrier Saccharomyces cerevisiae YOR100C increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1488 852324 CSG2 Calcium Sensitive Growth Saccharomyces cerevisiae YBR036C CLS2 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 139 856142 CSR2 Csr2p Saccharomyces cerevisiae YPR030W ART8 MRG19 increase Deletion results in higher levels of intracellular reactive oxygen species, augmentation of scavenging enzymes and extended lifespan. anti Deletion 2269: Kharade et al. (2005) "Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence." FEBS Lett. 579(30):6809-6813 (16336970) 1583 852330 CST26 Chromosome STability Saccharomyces cerevisiae YBR042C PSI1 increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1694 851843 CTA1 CaTalase A Saccharomyces cerevisiae YDR256C increase Deletion caused increase in mean chronological lifespan in the alpha strain anti Deletion 2528: Mesquita et al. (2010) "Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity." Proc. Natl. Acad. Sci. U.S.A. 107(34):15123-15128 (20696905) 1694 851843 CTA1 CaTalase A Saccharomyces cerevisiae YDR256C decrease Overexpression resulted in a decrease in mean chronological lifespan in the alpha strain anti Overexpression 2528: Mesquita et al. (2010) "Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity." Proc. Natl. Acad. Sci. U.S.A. 107(34):15123-15128 (20696905) 1622 856254 CTF4 Chromosome Transmission Fidelity Saccharomyces cerevisiae YPR135W CHL15 POB1 decrease Replicative lifespan decreased pro Deletion 1425: Hoopes et al. (2002) "Mutations in DNA replication genes reduce yeast life span." Mol. Cell. Biol. 22(12):4136-4146 (12024027) 1653 851729 CTH1 Cysteine-Three-Histidine Saccharomyces cerevisiae YDR151C increase Replicative lifespan increased by 20% in the a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1630 853718 CTK1 Carboxy-Terminal domain Kinase Saccharomyces cerevisiae YKL139W decrease Replicative lifespan decreased by 80% in the alpha strain fitness 80 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1224 856241 CTR1 Copper TRansport Saccharomyces cerevisiae YPR124W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1224 856241 CTR1 Copper TRansport Saccharomyces cerevisiae YPR124W decrease Deletion caused replicative lifespan decrease by 95.0% in the alpha strain and by 66.4% in the a strain fitness 95 Deletion 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 1224 856241 CTR1 Copper TRansport Saccharomyces cerevisiae YPR124W increase Overexpression caused replicative lifespan increase by 25.4% in the alpha strain and by 11.7% in the a strain pro 25 Overexpression 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 141 852979 CTT1 Cytosolic catalase T Saccharomyces cerevisiae YGR088W SPS101 increase Overexpression in combination with SOD1 increases stationary phase survival by about 10%. Overexpression of CTT1 alone slightly shortens stationary phase survival. Overexpression 2271: Fabrizio et al. (2003) "SOD2 functions downstream of Sch9 to extend longevity in yeast." Genetics 163(1):35-46 (12586694) 1631 855926 CUP9 Cup9p Saccharomyces cerevisiae YPL177C decrease Replicative lifespan increased by 30% in the alpha and a strains fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1044 850376 CWH43 Calcofluor White Hypersensitive Saccharomyces cerevisiae YCR017C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1044 850376 CWH43 Calcofluor White Hypersensitive Saccharomyces cerevisiae YCR017C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1891 855612 CYB5 Cyb5p Saccharomyces cerevisiae Deletion of CYB5 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1045 853507 CYC1 CYtochrome C Saccharomyces cerevisiae YJR048W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1045 853507 CYC1 CYtochrome C Saccharomyces cerevisiae YJR048W decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1045 853507 CYC1 CYtochrome C Saccharomyces cerevisiae YJR048W decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1046 854202 CYC2 CYtochrome C Saccharomyces cerevisiae YOR037W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1414 851192 CYC3 CYtochrome C Saccharomyces cerevisiae YAL039C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 149 853452 CYR1 Adenylate cyclase Saccharomyces cerevisiae YJL005W CDC35 FIL1 HSR1 SRA4 TSM0185 increase Knocking out gene extends replicative lifespan by 75%. anti 75 Knockout 2274: Lin et al. (2002) "Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration." Nature 418(6895):344-348 (12124627) 149 853452 CYR1 Adenylate cyclase Saccharomyces cerevisiae YJL005W CDC35 FIL1 HSR1 SRA4 TSM0185 increase Mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, increase resistance to oxidants and extend LS by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension. A transposon mutagenized allele of CYR1 extends chronological life span, as measured by stationary phase survival, by 90%. anti 90 Mutations 2346: Fabrizio et al. (2001) "Regulation of longevity and stress resistance by Sch9 in yeast." Science 292(5515):288-290 (11292860) 149 853452 CYR1 Adenylate cyclase Saccharomyces cerevisiae YJL005W CDC35 FIL1 HSR1 SRA4 TSM0185 increase The CDC35-1 allele confers a 75% extension of replicative life span at 25 C anti 75 Mutation 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 1569 853059 CYS4 CYStathionine beta-synthase Saccharomyces cerevisiae YGR155W NHS5 STR4 VMA41 increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1701 854231 CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Saccharomyces cerevisiae YOR065W CTC1 YOR29-16 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1701 854231 CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Saccharomyces cerevisiae YOR065W CTC1 YOR29-16 decrease Replicative lifespan decreased by 20% in a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1047 853775 CYT2 cytochrome c1 heme lyase CYT2 Saccharomyces cerevisiae YKL087C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1047 853775 CYT2 cytochrome c1 heme lyase CYT2 Saccharomyces cerevisiae YKL087C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1047 853775 CYT2 cytochrome c1 heme lyase CYT2 Saccharomyces cerevisiae YKL087C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1742 856423 DAP2 YHR028C Saccharomyces cerevisiae YHR028C DPP2 decrease DAP2 deletion decreases mean and maximum replicative lifespan under ad libitum, and cancels the lifespan extending effect of moderate dietary restriction. fitness 36 19 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1554 851583 DAS2 Dst1-delta 6-Azauracil Sensitivity Saccharomyces cerevisiae YDR020C RRT3 increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1555 852984 DBF2 DumbBell Forming Saccharomyces cerevisiae YGR092W decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1362 855984 DBP1 Dead Box Protein Saccharomyces cerevisiae YPL119C LPH8 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1702 852802 DBP3 Dead Box Protein Saccharomyces cerevisiae YGL078C increase Replicative lifespan increased by 35% in the alpha strain and by 20% in the a strain anti 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1048 850819 DCN1 Defective in Cullin Neddylation Saccharomyces cerevisiae YLR128W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1394 853820 DCW1 Defective Cell Wall Saccharomyces cerevisiae YKL046C increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1865 852500 DER1 Der1p Saccharomyces cerevisiae increase Deletion of der1, a target of the unfolded protein response signaling, increases replicative lifespan. anti 16 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1049 853738 DGR2 2-Deoxy-Glucose Resistant 2 Saccharomyces cerevisiae YKL121W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1225 853906 DID2 Doa4-Independent Degradation Saccharomyces cerevisiae YKR035W-A CHM1 FTI1 VPL30 VPS46 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1532 853142 DIE2 Derepression of ITR1 Expression Saccharomyces cerevisiae YGR227W ALG10 increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1532 853142 DIE2 Derepression of ITR1 Expression Saccharomyces cerevisiae YGR227W ALG10 increase Deletion of die2, a target of the unfolded protein response signaling, decreases replicative lifespan. anti -17 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1385 851157 DIF1 Damage-regulated Import Facilitator Saccharomyces cerevisiae YLR437C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1968 853381 DLS1 Dls1p Saccharomyces cerevisiae increase Deletion of DLS1 in yeast extends replicative lifespan by 20%. anti 20 Deletion 3477: Dang et al. (2014) "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response." Cell Metab. 19(6):952-966 (24814484) 183 856569 DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent Saccharomyces cerevisiae YHR164C WEB2 decrease Mutants exhibit an accelerated ageing phenotype including extended cell cycle time, age-related transcriptional silencing defects, and nucleolar reorganization. pro Mutation 1425: Hoopes et al. (2002) "Mutations in DNA replication genes reduce yeast life span." Mol. Cell. Biol. 22(12):4136-4146 (12024027) 1571 856913 DNF1 Drs2 Neo1 Family Saccharomyces cerevisiae YER166W increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 185 850686 DNM1 Dnm1p Saccharomyces cerevisiae YLL001W increase Deletion delayed ageing. anti Deletion 2286: Scheckhuber et al. (2007) "Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models." Nat. Cell Biol. 9(1):99-9105 (17173038) 1473 851641 DOA4 Degradation Of Alpha Saccharomyces cerevisiae YDR069C DOS1 MUT4 NPI2 SSV7 UBP4 decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1918 852050 DOT1 histone methyltransferase DOT1 Saccharomyces cerevisiae KMT4 PCH1 decrease Deletion of histone methyltransferase DOT1 results in an decreased replicative lifespan. fitness 24 Deletion 3524: Ryu et al. (2014) "Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells." Biochem. Biophys. Res. Commun. 446(1):113-118 (24607280) 1969 851699 DPB4 Dpb4p Saccharomyces cerevisiae decrease Deletion of DLS1 in yeast shortens replicative lifespan by 15%. fitness 15 Deletion 3477: Dang et al. (2014) "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response." Cell Metab. 19(6):952-966 (24814484) 1050 854703 DPH1 DiPHthamide biosynthesis Saccharomyces cerevisiae YIL103W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1226 855331 DSS1 Deletion of SUV3 Supressor Saccharomyces cerevisiae YMR287C MSU1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1226 855331 DSS1 Deletion of SUV3 Supressor Saccharomyces cerevisiae YMR287C MSU1 increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 35 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1509 850605 DUG1 Deficient in Utilization of Glutathione Saccharomyces cerevisiae YFR044C increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1227 852584 DUG2 Deficient in Utilization of Glutathione Saccharomyces cerevisiae YBR281C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1496 851457 DUN1 DNA-damage UNinducible Saccharomyces cerevisiae YDL101C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1051 852034 DYN2 DYNein Saccharomyces cerevisiae YDR424C SLC1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1228 852370 ECM33 ExtraCellular Mutant Saccharomyces cerevisiae YBR078W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1308 856342 ECM34 ExtraCellular Mutant Saccharomyces cerevisiae YHL043W decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1426 854301 EFT1 Elongation Factor Two Saccharomyces cerevisiae YOR133W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1052 851993 EFT2 Elongation Factor Two Saccharomyces cerevisiae YOR133W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1053 856070 EGD1 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae YPL037C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1415 856600 EGD2 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae YHR193C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1617 856019 ELP3 ELongator Protein Saccharomyces cerevisiae YPL086C HPA1 KTI8 TOT3 increase Survival increased during early chronological aging (day 5-15); anti Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1684 856002 ELP4 ELongator Protein Saccharomyces cerevisiae YPL101W HAP1 KTI9 TOT7 increase Replicative lifespan increased by 10-30% in both alpha and a strains anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1054 852125 EMI1 Early Meiotic Induction Saccharomyces cerevisiae YDR512C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1054 852125 EMI1 Early Meiotic Induction Saccharomyces cerevisiae YDR512C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1551 852962 ENV11 late ENdosome and Vacuole interface function Saccharomyces cerevisiae YGR071C decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 2138 855644 EOS1 Eos1p Saccharomyces cerevisiae increase Deletion of EOS1 in yeast increased mean replicative lifespan. anti 24 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1363 855441 ERG24 ERGosterol biosynthesis Saccharomyces cerevisiae YNL280C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1703 855029 ERG5 ERGosterol biosynthesis Saccharomyces cerevisiae YMR015C CYP61 decrease Replicative lifespan decreased by 35% in the a strain fitness 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1665 855003 ERG6 ERGosterol biosynthesis Saccharomyces cerevisiae YML008C ISE1 LIS1 SED6 VID1 decrease Replicative lifespan decreased by 50% on CR medium fitness 50 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1665 855003 ERG6 ERGosterol biosynthesis Saccharomyces cerevisiae YML008C ISE1 LIS1 SED6 VID1 no change Deletion of ERG6 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1863 854909 ERO1 ER oxidoreductin Saccharomyces cerevisiae increase Deletion of ero1, a target of the unfolded protein response signaling, increases replicative lifespan. anti 28 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1342 856152 ERV2 Essential for Respiration and Viability Saccharomyces cerevisiae YPR037C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1481 851965 ESC2 Establishment of Silent Chromatin Saccharomyces cerevisiae YDR363W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1197 853971 ESL2 Est1A/B-Smg6/5-Like Saccharomyces cerevisiae YKR096W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1704 852314 ETR1 2-Enoyl Thioester Reductase Saccharomyces cerevisiae YBR026C MRF1 MRF1' decrease Replicative lifespan decreased by 45% in the a strain fitness 45 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1229 852130 EUG1 ER protein Unnecessary for Growth Saccharomyces cerevisiae YDR518W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1229 852130 EUG1 ER protein Unnecessary for Growth Saccharomyces cerevisiae YDR518W increase Deletion of eug1, a target of the unfolded protein response signaling, increases replicative lifespan. anti 11 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1230 854198 EXO1 EXOnuclease Saccharomyces cerevisiae YOR033C DHS1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1510 850939 FAR10 Factor ARrest Saccharomyces cerevisiae YLR238W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1309 850559 FAR7 Factor ARrest Saccharomyces cerevisiae YFR008W decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1309 850559 FAR7 Factor ARrest Saccharomyces cerevisiae YFR008W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1511 855044 FAR8 Factor ARrest Saccharomyces cerevisiae YMR029C increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1231 852329 FAT1 FATty acid transporter Saccharomyces cerevisiae YBR041W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 280 851092 FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for gluc Saccharomyces cerevisiae YLR377C ACN8 decrease Deletion did increase survival during the first 15 days during chronological ageing, but did not increase chronological lifespan. Deletion reduced production of reactive oxygen species while overexpression shortened lifespan. anti Overexpression 2293: Kitanovic and Wölfl (2006) "Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae." Mutat. Res. 594(1-2):135-147 (16199065) 1395 856175 FCY1 FluoroCYtosine resistance Saccharomyces cerevisiae YPR062W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1343 856783 FCY2 FluoroCYtosine resistance Saccharomyces cerevisiae YER056C BRA7 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1344 856788 FCY21 FluoroCYtosine resistance Saccharomyces cerevisiae YER060W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1310 855080 FET3 FErrous Transport Saccharomyces cerevisiae YMR058W decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1437 855392 FIG4 Factor-Induced Gene Saccharomyces cerevisiae YNL325C decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1427 851708 FIN1 Filaments In between Nuclei Saccharomyces cerevisiae YDR130C decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 283 854745 FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Saccharomyces cerevisiae YIL065C MDV2 increase Deletion prolonged the lifespan and improved the fitness of old mother cells. anti Deletion 2286: Scheckhuber et al. (2007) "Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models." Nat. Cell Biol. 9(1):99-9105 (17173038) 283 854745 FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Saccharomyces cerevisiae YIL065C MDV2 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1055 851120 FLD1 Few Lipid Droplets Saccharomyces cerevisiae YLR404W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1311 854709 FMC1 Formation of Mitochondrial Complexes Saccharomyces cerevisiae YIL098C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1489 851642 FMP16 Found in Mitochondrial Proteome Saccharomyces cerevisiae YDR070C decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1386 853923 FMP46 Found in Mitochondrial Proteome Saccharomyces cerevisiae YKR049C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1056 852270 FMT1 Formyl-Methionyl-tRNA Transformylase Saccharomyces cerevisiae YBL013W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 284 851688 FOB1 Fob1p Saccharomyces cerevisiae YDR110W HRM1 increase Knocking out this gene extends lifespan by 30-50%. anti 50 Knockout 2294: Defossez et al. (1999) "Elimination of replication block protein Fob1 extends the life span of yeast mother cells." Mol. Cell 3(4):447-455 (10230397) 284 851688 FOB1 Fob1p Saccharomyces cerevisiae YDR110W HRM1 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 284 851688 FOB1 Fob1p Saccharomyces cerevisiae YDR110W HRM1 increase About 20% mean replicative lifespan increase anti 20 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 284 851688 FOB1 Fob1p Saccharomyces cerevisiae YDR110W HRM1 increase Deletion of fob1 causes extension in the short life span of the sir2 mutant extended by ~50% anti 50 Deletion 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 284 851688 FOB1 Fob1p Saccharomyces cerevisiae YDR110W HRM1 increase Replicative lifespan increased by 25% in the alpha strain and by 10% in a strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1438 853878 FOX2 Fatty acid OXidation Saccharomyces cerevisiae YKR009C POX2 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1747 850675 FRE6 Ferric REductase 6 Saccharomyces cerevisiae YLL051C increase FRE6 deletion increases mean replicative lifespan. This is not further extended by dietary restriction. anti 14 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1312 856888 FTR1 Fe TRansporter Saccharomyces cerevisiae YER145C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1232 855866 FUM1 FUMarase Saccharomyces cerevisiae YPL262W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1605 851196 FUN12 Function Unknown Now Saccharomyces cerevisiae YAL035W yIF2 decrease Replicative lifespan decreased by 40% in the a strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1734 852638 FZF1 Five Zinc Fingers Saccharomyces cerevisiae YGL254W NRC299 RSU1 SUL1 increase Mean replicative lifespan increased by 66% in the alpha strain anti 66 Deletion 2531: Yoshida et al. (2010) "Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants." Aging Cell 9(4):616-625 (20550517) 1057 854954 GAL80 GALactose metabolism Saccharomyces cerevisiae YML051W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1387 855355 GAS1 Glycophospholipid-Anchored Surface protein Saccharomyces cerevisiae YMR307W CWH52 GGP1 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1685 851877 GCN2 General Control Nonderepressible Saccharomyces cerevisiae YDR283C AAS1 AAS102 NDR2 increase Replicative lifespan decreased by by 10-20% in both alpha and a strains anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1685 851877 GCN2 General Control Nonderepressible Saccharomyces cerevisiae YDR283C AAS1 AAS102 NDR2 decrease Replicative lifespan decreased by 10% in a strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1058 856709 GCN4 General Control Nonderepressible Saccharomyces cerevisiae YEL009C AAS101 AAS3 ARG9 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1058 856709 GCN4 General Control Nonderepressible Saccharomyces cerevisiae YEL009C AAS101 AAS3 ARG9 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1058 856709 GCN4 General Control Nonderepressible Saccharomyces cerevisiae YEL009C AAS101 AAS3 ARG9 increase Replicative lifespan increased by 10% in the alpha strain anti 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 295 853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae YGR252W AAS104 ADA4 SWI9 decrease Deletion suppressed extension of replicative lifespan. fitness Deletion 2299: Kim et al. (2004) "The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity." Biogerontology 5(5):305-316 (15547318) 295 853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae YGR252W AAS104 ADA4 SWI9 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 295 853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae YGR252W AAS104 ADA4 SWI9 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 295 853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae YGR252W AAS104 ADA4 SWI9 decrease Strongly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1059 851237 GDH3 Glutamate DeHydrogenase Saccharomyces cerevisiae YAL062W FUN51 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1233 854380 GEP3 GEnetic interactors of Prohibitins Saccharomyces cerevisiae YOR205C AIM40 FMP38 MTG3 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1234 856817 GET2 Guided Entry of Tailanchored proteins Saccharomyces cerevisiae YER083C HUR2 RMD7 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1060 850321 GFD2 Great for Full DEAD box protein activity Saccharomyces cerevisiae YCL036W YCD6 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1061 850318 GID7 Glucose Induced Degradation deficient Saccharomyces cerevisiae YCL039W MOH2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1062 855166 GID8 Glucose Induced Degradation deficient Saccharomyces cerevisiae YMR135C DCR1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1062 855166 GID8 Glucose Induced Degradation deficient Saccharomyces cerevisiae YMR135C DCR1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1577 852119 GIN4 Growth Inhibitory Saccharomyces cerevisiae YDR507C ERC47 decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1577 852119 GIN4 Growth Inhibitory Saccharomyces cerevisiae YDR507C ERC47 decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1544 851670 GIS1 GIg1-2 Suppressor Saccharomyces cerevisiae YDR096W increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1624 850317 GLK1 GLucoKinase Saccharomyces cerevisiae YCL040W HOR3 decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1624 850317 GLK1 GLucoKinase Saccharomyces cerevisiae YCL040W HOR3 decrease Deletion of GLK1 decreases yeast chronological lifespan. fitness Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 307 856763 GLN3 Gln3p Saccharomyces cerevisiae YER040W increase Deletion extends chronological lifespan. anti Deletion 2238: Powers et al. (2006) "Extension of chronological life span in yeast by decreased TOR pathway signaling." Genes Dev. 20(2):174-184 (16418483) 307 856763 GLN3 Gln3p Saccharomyces cerevisiae YER040W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 307 856763 GLN3 Gln3p Saccharomyces cerevisiae YER040W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1479 851166 GMC2 Grand Meiotic recombination Cluster Saccharomyces cerevisiae YLR445W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 319 856741 GPA2 Gpa2p Saccharomyces cerevisiae YER020W SSP101 increase Deletion increases lifespan by about 50%. anti 50 Deletion 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 319 856741 GPA2 Gpa2p Saccharomyces cerevisiae YER020W SSP101 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1063 854553 GPB1 Gpb1p Saccharomyces cerevisiae YOR371C KRH2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 323 851527 GPR1 Gpr1p Saccharomyces cerevisiae YDL035C increase Deletion increases lifespan by about 50%. anti 50 Deletion 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 1064 853941 GPT2 Glycerol-3-Phosphate acylTransferase Saccharomyces cerevisiae YKR067W GAT1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1578 852546 GPX2 Glutathione PeroXidase Saccharomyces cerevisiae YBR244W AMI1 decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1911 856504 GRE3 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Saccharomyces cerevisiae increase Knockout of GRE3 results in an extended chronological median lifespan. anti 100 Knockout 3519: Yizhak et al. (2013) "Model-based identification of drug targets that revert disrupted metabolism and its application to ageing." Nat Commun 4:2632 (24153335) 1364 850962 GSY2 Glycogen SYnthase Saccharomyces cerevisiae YLR258W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1746 854918 GTR1 GTp binding protein Resemblance 1 Saccharomyces cerevisiae YML121W decrease GTR1 deletion decreases mean and maximum replicative lifespan under ad libitum, and cancels out the lifespan extending effect of DR fitness 51 36 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1614 854651 GUT2 Glycerol UTilization Saccharomyces cerevisiae YIL155C increase Replicative lifespan increased by 25% pro 25 Overexpression 2511: Easlon et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944 (18381895) 1066 854236 GYP1 Gtpase-activating protein for YPt1p Saccharomyces cerevisiae YOR070C YOR29-21 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1462 852260 HAP3 Heme Activator Protein Saccharomyces cerevisiae YBL021C decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 332 853751 HAP4 Hap4p Saccharomyces cerevisiae YKL109W increase Overexpression extends lifespan about 40% under growth conditions favoring fermentation. pro 40 Overexpression 2274: Lin et al. (2002) "Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration." Nature 418(6895):344-348 (12124627) 332 853751 HAP4 Hap4p Saccharomyces cerevisiae YKL109W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1463 856106 HAT1 Histone AcetylTransferase Saccharomyces cerevisiae YPL001W decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 333 856654 HAT2 Hat2p Saccharomyces cerevisiae YEL056W increase Mutants have an extended lifespan (by 30%). 30 Mutation 2304: Rosaleny et al. (2005) "Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes." FEBS Lett. 579(19):4063-4068 (16023114) 1870 850429 HCM1 Hcm1p Saccharomyces cerevisiae increase Strong overexpression of HCM1 results in a 30% increase in yeast replicative lifespan when comparing to wild-type, while weaker overexpression has no effect on life span. Complementary, HCM1 deletion results in a 30% decrease in yeast replicative lifespan. Manipulation of HCM1 levels does not extend yeast chronological life span. pro 30 Overexpression 3494: Maoz et al. (2015) "The yeast forkhead HCM1 controls life span independent of calorie restriction." J. Gerontol. A Biol. Sci. Med. Sci. 70(4):444-453 (24835838) 1675 855710 HDA1 Histone DeAcetylase Saccharomyces cerevisiae YNL021W increase Slightly increased chronological lifespan anti Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1618 851889 HDA2 Histone DeAcetylase Saccharomyces cerevisiae YDR295C PLO2 decrease Strongly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1235 855338 HER2 Hmg2p ER Remodeling Saccharomyces cerevisiae YMR293C GEP6 RRG6 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1841 854412 HES1 Hes1p Saccharomyces cerevisiae OSH5 decrease Overexpression of OSH5 (PERG6-OSH5 mean 20, median 20.5) significantly shortened replicative lifespan. anti 30 25 Overexpression 3273: Gebre et al. (2012) "Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion." Cell Cycle 11(11):2176-2188 (22622083) 1067 855247 HFA1 acetyl-CoA carboxylase HFA1 Saccharomyces cerevisiae YMR207C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1068 852275 HIR1 HIstone Regulation Saccharomyces cerevisiae YBL008W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1068 852275 HIR1 HIstone Regulation Saccharomyces cerevisiae YBL008W increase Inactivation of any component of the Hir complex extended the median replicative life span by 25%-35%. anti 35 Deletion 2542: Feser et al. (2010) "Elevated histone expression promotes life span extension." Mol. Cell 39(5):724-735 (20832724) 1069 854203 HIR2 HIstone Regulation Saccharomyces cerevisiae YOR038C SPT1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1069 854203 HIR2 HIstone Regulation Saccharomyces cerevisiae YOR038C SPT1 increase Inactivation of any component of the Hir complex extended the median replicative life span by 25%-35%. anti 35 Deletion 2542: Feser et al. (2010) "Elevated histone expression promotes life span extension." Mol. Cell 39(5):724-735 (20832724) 1070 853605 HIR3 HIstone Regulation Saccharomyces cerevisiae YJR140C HPC1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1070 853605 HIR3 HIstone Regulation Saccharomyces cerevisiae YJR140C HPC1 increase Inactivation of any component of the Hir complex extended the median replicative life span by 25%-35%. anti 35 Deletion 2542: Feser et al. (2010) "Elevated histone expression promotes life span extension." Mol. Cell 39(5):724-735 (20832724) 1071 852550 HIS7 HIStidine requiring Saccharomyces cerevisiae YBR248C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1236 854058 HMI1 Helicase in MItochondria Saccharomyces cerevisiae YOL095C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1533 852322 HMT1 HnRNP MethylTransferase Saccharomyces cerevisiae YBR034C HCP1 ODP1 RMT1 increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1345 852803 HNM1 Hyper-resistance to Nitrogen Mustard Saccharomyces cerevisiae YGL077C CTR1 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1072 854432 HNT3 Histidine triad NucleoTide-binding Saccharomyces cerevisiae YOR258W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1396 852008 HPT1 Hypoxanthine guanine PhosphoribosylTransferase Saccharomyces cerevisiae YDR399W BRA6 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1455 855728 HRB1 Hypothetical RNA-Binding protein Saccharomyces cerevisiae YNL004W TOM34 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1313 854149 HRD1 HMG-coA Reductase Degradation Saccharomyces cerevisiae YOL013C DER3 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1313 854149 HRD1 HMG-coA Reductase Degradation Saccharomyces cerevisiae YOL013C DER3 increase Deletion of hrd1, a target of the unfolded protein response signaling, increases replicative lifespan. anti 18 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1237 850904 HRD3 HMG-coA Reductase Degradation Saccharomyces cerevisiae YLR207W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1365 850786 HRT3 High level expression Reduces Ty3 transposition Saccharomyces cerevisiae YLR097C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1073 856387 HSE1 Has Symptoms of class E mutants; resembles Hbp, Stam and East Saccharomyces cerevisiae YHL002W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1073 856387 HSE1 Has Symptoms of class E mutants; resembles Hbp, Stam and East Saccharomyces cerevisiae YHL002W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1073 856387 HSE1 Has Symptoms of class E mutants; resembles Hbp, Stam and East Saccharomyces cerevisiae YHL002W increase Replicative lifespan increased by 25% in the alpha strain and 15% in the a strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 347 850633 HSP104 chaperone ATPase HSP104 Saccharomyces cerevisiae YLL026W decrease A 40% reduction in replicative lifespan was observed in knockouts. Overexpression had no effect on replicative lifespan but suppressed the reduced lifespan of Sir2-deficient cells. fitness 40 Knockout 2306: Erjavec et al. (2007) "Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p." Genes Dev. 21(19):2410-2421 (17908928) 1074 854086 HST1 Homolog of SIR Two (SIR2) Saccharomyces cerevisiae YOL068C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 353 856092 HST2 Hst2p Saccharomyces cerevisiae YPL015C increase Overexpression results in replicative lifespan extension. pro Overexpression 2309: Lamming et al. (2005) "HST2 mediates SIR2-independent life-span extension by calorie restriction." Science 309(5742):1861-1864 (16051752) 1238 856464 HTD2 Hydroxyacyl-Thioester Dehydratase Saccharomyces cerevisiae YHR067W RMD12 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 357 852639 HXK2 hexokinase 2 Saccharomyces cerevisiae YGL253W HEX1 HKB SCI2 increase Deletion extends lifespan about 50%. anti 50 Deletion 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 357 852639 HXK2 hexokinase 2 Saccharomyces cerevisiae YGL253W HEX1 HKB SCI2 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1239 856496 HXT5 HeXose Transporter Saccharomyces cerevisiae YHR096C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1534 853586 IBA57 Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins Saccharomyces cerevisiae YJR122W CAF17 increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1075 856794 ICL1 IsoCitrate Lyase Saccharomyces cerevisiae YER065C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1705 855691 IDH1 Isocitrate DeHydrogenase Saccharomyces cerevisiae YNL037C increase Replicative lifespan increased by 15% in the alpha strain and 10% in the a strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 358 854303 IDH2 Idh2p Saccharomyces cerevisiae YOR136W increase Deletion increased the mean replicative lifespan by about 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 358 854303 IDH2 Idh2p Saccharomyces cerevisiae YOR136W increase Replicative lifespan increased by 20% in the alpha strain and in a strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 358 854303 IDH2 Idh2p Saccharomyces cerevisiae YOR136W increase Replicative lifespan increased by 20% in the alpha strain and in a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1346 851493 IDP1 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YDL066W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1346 851493 IDP1 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YDL066W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1366 850871 IDP2 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YLR174W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1366 850871 IDP2 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YLR174W increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1366 850871 IDP2 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YLR174W decrease Replicative lifespan decreased by 10% in the a strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1642 855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YNL009W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1642 855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YNL009W decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1642 855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YNL009W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1642 855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae YNL009W decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1619 851100 IKI3 Insensitive to KIller toxin Saccharomyces cerevisiae YLR384C ELP1 KTI7 TOT1 increase Survival increased during early chronological aging (day 5-15); anti Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 2127 850413 IMG1 mitochondrial 54S ribosomal protein IMG1 Saccharomyces cerevisiae increase Deletion of IMG1 in yeast increased mean replicative lifespan. anti 23 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 2128 850434 IMG2 mitochondrial 54S ribosomal protein IMG2 Saccharomyces cerevisiae increase Deletion of IMG2 in yeast increased mean replicative lifespan. anti 28 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1564 856442 INM1 INositol Monophosphatase Saccharomyces cerevisiae YHR046C increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1564 856442 INM1 INositol Monophosphatase Saccharomyces cerevisiae YHR046C increase Replicative lifespan increased by 50% in the alpha strain anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1564 856442 INM1 INositol Monophosphatase Saccharomyces cerevisiae YHR046C decrease Replicative lifespan decreased by 10% in a strain fitness 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1601 851881 INM2 INositol Monophosphatase Saccharomyces cerevisiae YDR287W decrease Replicative lifespan decreased by 70% in the alpha strain fitness 70 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1240 854042 INO4 INOsitol requiring Saccharomyces cerevisiae YOL108C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1625 854815 INP51 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YIL002C SJL1 increase Replicative lifespan increased by 10% in the alpha strain and in a strain anti 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1625 854815 INP51 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YIL002C SJL1 increase Replicative lifespan increased by 10% in the alpha strain and in a strain anti 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1367 854276 INP53 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOR109W SJL3 SOP2 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1367 854276 INP53 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOR109W SJL3 SOP2 decrease Replicative lifespan decreased fitness Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1367 854276 INP53 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOR109W SJL3 SOP2 decrease Replicative lifespan decreased by 30% in the alpha strain and by 10% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1520 854089 INP54 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOL065C increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1520 854089 INP54 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOL065C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1520 854089 INP54 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae YOL065C decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1565 851910 IPK1 Inositol Polyphosphate Kinase Saccharomyces cerevisiae YDR315C GSL1 increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1565 851910 IPK1 Inositol Polyphosphate Kinase Saccharomyces cerevisiae YDR315C GSL1 increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1428 851644 IPT1 InositolPhosphoTransferase Saccharomyces cerevisiae YDR072C KTI6 SYR4 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1428 851644 IPT1 InositolPhosphoTransferase Saccharomyces cerevisiae YDR072C KTI6 SYR4 increase Chronological lifespan increased by 40% anti 40 Deletion 2519: Aerts et al. (2006) "Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast." FEBS Lett. 580(7):1903-1907 (16527275) 1241 856739 ISC1 Inositol phosphoSphingolipid phospholipase C Saccharomyces cerevisiae YER019W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1241 856739 ISC1 Inositol phosphoSphingolipid phospholipase C Saccharomyces cerevisiae YER019W decrease Chronological lifespan decreased pro Deletion 2507: Almeida et al. (2008) "Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis." Mol. Biol. Cell 19(3):865-876 (18162582) 1706 856067 ISM1 Isoleucyl tRNA Synthetase of Mitochondria Saccharomyces cerevisiae YPL040C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1706 856067 ISM1 Isoleucyl tRNA Synthetase of Mitochondria Saccharomyces cerevisiae YPL040C decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1397 852547 ISW1 Imitation SWitch subfamily Saccharomyces cerevisiae YBR245C SGN2 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1397 852547 ISW1 Imitation SWitch subfamily Saccharomyces cerevisiae YBR245C SGN2 decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1966 854480 ISW2 Isw2p Saccharomyces cerevisiae increase Deletion of ISW2 in yeast extends replicative lifespan by 24%. anti 24 Deletion 3477: Dang et al. (2014) "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response." Cell Metab. 19(6):952-966 (24814484) 1967 852744 ITC1 Itc1p Saccharomyces cerevisiae increase Deletion of ITC1 in yeast extends replicative lifespan by 18%. anti 18 Deletion 3477: Dang et al. (2014) "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response." Cell Metab. 19(6):952-966 (24814484) 1076 850710 IZH3 Implicated in Zinc Homeostasis Saccharomyces cerevisiae YLR023C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1242 856174 JID1 DnaJ protein Involved in ER-associated Degradation Saccharomyces cerevisiae YPR061C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1077 855339 JNM1 Just Nuclear Migration Saccharomyces cerevisiae YMR294W INS1 PAC3 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1707 856263 KAR3 KARyogamy Saccharomyces cerevisiae YPR141C OSR11 increase Replicative lifespan increased by 55% in the alpha strain anti 55 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1243 855483 KEX2 Killer EXpression defective Saccharomyces cerevisiae YNL238W QDS1 SRB1 VMA45 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1078 854681 KGD1 alpha-KetoGlutarate Dehydrogenase Saccharomyces cerevisiae YIL125W OGD1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1078 854681 KGD1 alpha-KetoGlutarate Dehydrogenase Saccharomyces cerevisiae YIL125W OGD1 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 397 852931 KSS1 Kss1p Saccharomyces cerevisiae YGR040W decrease Deletion resulted in increased sensitivity to heat shock and oxidative stress and a 33% reduction in median lifespan. fitness 33 Deletion 1845: Yan et al. (2007) "Type 5 adenylyl cyclase disruption increases longevity and protects against stress." Cell 130(2):247-258 (17662940) 398 856386 LAG1 Ceramide synthase component Saccharomyces cerevisiae YHL003C increase Deletion increased mean and maximum lifespan by approximately 50%. anti 50 50 Deletion 2249: D'mello et al. (1994) "Cloning and characterization of LAG1, a longevity-assurance gene in yeast." J. Biol. Chem. 269(22):15451-15459 (8195187) 399 854133 LAG2 Lag2p Saccharomyces cerevisiae YOL025W ECM36 increase Overexpression extended mean and maximum lifespan by 36% and 54%, respectively. pro 54 36 Overexpression 2316: Childress et al. (1996) "LAG2, a gene that determines yeast longevity." Microbiology (Reading, Engl.) 142 ( Pt 8):2289-2297 (8760941) 1244 853384 LAS21 Local Anestheticum Sensitive Saccharomyces cerevisiae YJL062W GPI7 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 400 855653 LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes Saccharomyces cerevisiae YNL071W ODP2 PDA2 increase Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase. pro 20 Overexpression 2317: Easlon et al. (2007) "The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension." J. Biol. Chem. 282(9):6161-6171 (17200108) 1512 853307 LCB3 Long-Chain Base Saccharomyces cerevisiae YJL134W LBP1 YSR2 increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1356 856051 LCL1 Long Chronological Lifespan Saccharomyces cerevisiae YPL056C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1411 850794 LCL2 Long Chronological Lifespan 2 Saccharomyces cerevisiae YLR104W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1410 852795 LCL3 Long Chronological Lifespan 3 Saccharomyces cerevisiae YGL085W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1079 850351 LDB16 Low Dye Binding Saccharomyces cerevisiae YCL005W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1080 854500 LDB19 Low Dye Binding Saccharomyces cerevisiae YOR322C ART1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1638 850342 LEU2 LEUcine biosynthesis Saccharomyces cerevisiae YCL018W increase Increased chronological lifespan anti Deletion 2515: Alvers et al. (2009) "Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae." Aging Cell 8(4):353-369 (19302372) 1639 851172 LEU3 LEUcine biosynthesis Saccharomyces cerevisiae YLR451W increase Increased chronological lifespan anti Deletion 2515: Alvers et al. (2009) "Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae." Aging Cell 8(4):353-369 (19302372) 1639 851172 LEU3 LEUcine biosynthesis Saccharomyces cerevisiae YLR451W increase Deletion of LEU3 increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1368 853789 LHS1 Lumenal Hsp Seventy Saccharomyces cerevisiae YKL073W CER1 SSI1 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1566 856561 LIN1 LINk Saccharomyces cerevisiae YHR156C SNU40 increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1566 856561 LIN1 LINk Saccharomyces cerevisiae YHR156C SNU40 increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1081 850940 LIP2 LIPoyl ligase Saccharomyces cerevisiae YLR239C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1579 850551 LOC1 LOCalization of ASH1 mRNA Saccharomyces cerevisiae YFR001W increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1082 853630 LOS1 Loss Of Suppression Saccharomyces cerevisiae YKL205W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1245 850527 LPD1 LiPoamide Dehydrogenase Saccharomyces cerevisiae YFL018C HPD1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1525 853037 LSB1 Las Seventeen Binding protein Saccharomyces cerevisiae YGR136W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1584 850580 LSB3 Las Seventeen Binding protein Saccharomyces cerevisiae YFR024C-A YFR024C increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1535 853345 LSB6 Las Seventeen Binding protein Saccharomyces cerevisiae YJL100W increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1886 854310 LSC1 succinate--CoA ligase (GDP-forming) subunit alpha Saccharomyces cerevisiae decrease Deletion of LSC1 decreases yeast chronological lifespan. fitness Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1887 853159 LSC2 succinate--CoA ligase (GDP-forming) subunit beta Saccharomyces cerevisiae decrease Deletion of LSC2 decreases yeast chronological lifespan. fitness Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1246 851984 LSM6 Like SM Saccharomyces cerevisiae YDR378C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1490 852948 LST7 Lethal with Sec Thirteen Saccharomyces cerevisiae YGR057C decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1083 854852 LYS1 LYSine requiring Saccharomyces cerevisiae YIR034C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 421 854714 LYS12 Isocitrate dehydrogenase Saccharomyces cerevisiae YIL094C LYS10 LYS11 increase Deletion extended chronological lifespan. anti Deletion 2238: Powers et al. (2006) "Extension of chronological life span in yeast by decreased TOR pathway signaling." Genes Dev. 20(2):174-184 (16418483) 421 854714 LYS12 Isocitrate dehydrogenase Saccharomyces cerevisiae YIL094C LYS10 LYS11 increase Extension of replicative life span anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1446 855786 LYS9 LYSine requiring Saccharomyces cerevisiae YNR050C LYS13 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1446 855786 LYS9 LYSine requiring Saccharomyces cerevisiae YNR050C LYS13 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1446 855786 LYS9 LYSine requiring Saccharomyces cerevisiae YNR050C LYS13 increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1530 853422 MAD2 Mitotic Arrest-Deficient Saccharomyces cerevisiae YJL030W increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1084 856657 MAK10 MAintenance of Killer Saccharomyces cerevisiae YEL053C NAA35 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1084 856657 MAK10 MAintenance of Killer Saccharomyces cerevisiae YEL053C NAA35 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1085 856163 MAK3 MAintenance of Killer Saccharomyces cerevisiae YPR051W NAA30 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1086 852600 MAL33 MALtose fermentation Saccharomyces cerevisiae YBR297W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1087 852483 MBA1 Multi-copy Bypass of AFG3 Saccharomyces cerevisiae YBR185C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1087 852483 MBA1 Multi-copy Bypass of AFG3 Saccharomyces cerevisiae YBR185C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1916 854372 MCA1 Ca(2+)-dependent cysteine protease MCA1 Saccharomyces cerevisiae YCA1 increase Lack of Mca1 has little effect on replicative life span in wild type yeast cells, and an accelerated aging effect in cells also lacking Ydj1. Overexpression of Mca1 extends lifespan by 46-56% in a Ydj1 dependent manner. pro 56 Overexpression 3523: Hill et al. (2014) "Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae." Science 344(6190):1389-1392 (24855027) 1247 854483 MCH5 MonoCarboxylate transporter Homologue Saccharomyces cerevisiae YOR306C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1615 853777 MDH1 Malate DeHydrogenase Saccharomyces cerevisiae YKL085W increase Replicative lifespan increased by 25% pro 25 Overexpression 2511: Easlon et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944 (18381895) 1616 853994 MDH2 Malate DeHydrogenase Saccharomyces cerevisiae YOL126C increase Replicative lifespan increased by 15% pro 15 Overexpression 2511: Easlon et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944 (18381895) 1314 854079 MDM20 Mitochondrial Distribution and Morphology Saccharomyces cerevisiae YOL076W DEC1 NAA25 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 430 852433 MEC1 Mec1p Saccharomyces cerevisiae YBR136W ESR1 RAD31 SAD3 decrease Mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion. fitness 66 Mutation 2267: Weinberger et al. (2007) "DNA replication stress is a determinant of chronological lifespan in budding yeast." PLoS ONE 2(8):e748 (17710147) 1088 856183 MED1 MEDiator complex Saccharomyces cerevisiae YPR070W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 432 855580 MEP2 Mep2p Saccharomyces cerevisiae YNL142W increase Deletion extended chronological lifespan. anti Deletion 2238: Powers et al. (2006) "Extension of chronological life span in yeast by decreased TOR pathway signaling." Genes Dev. 20(2):174-184 (16418483) 433 856260 MEP3 Mep3p Saccharomyces cerevisiae YPR138C increase Deletion extended chronological lifespan. anti Deletion 2238: Powers et al. (2006) "Extension of chronological life span in yeast by decreased TOR pathway signaling." Genes Dev. 20(2):174-184 (16418483) 1975 853869 MET14 adenylyl-sulfate kinase Saccharomyces cerevisiae increase Deletion of MET5 increases lifespan. anti Deletion 3479: Hine et al. (2015) "Endogenous hydrogen sulfide production is essential for dietary restriction benefits." Cell 160(1-2):132-144 (25542313) 1976 856296 MET16 phosphoadenylyl-sulfate reductase (thioredoxin) Saccharomyces cerevisiae increase Deletion of MET5 increases lifespan. anti Deletion 3479: Hine et al. (2015) "Endogenous hydrogen sulfide production is essential for dietary restriction benefits." Cell 160(1-2):132-144 (25542313) 1965 851010 MET17 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae MET15 MET25 increase Knockout of MET17 (previously known as MET15), which causes only in a moderate defect in methionine biosynthesis, results in both longer maximum and median chronological lifespan. The experiment was performed in synthetic complete medium supplemented with 30 mg/l methionine, and the MET15 strain showed equivalent cell counts and comparable cell cycle arrest with the controls and met2 strain. anti 115 100 Deletion 3475: Ruckenstuhl et al. (2014) "Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification." PLoS Genet. 10(5):e1004347 (24785424) 1089 855444 MET2 METhionine requiring Saccharomyces cerevisiae YNL277W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1089 855444 MET2 METhionine requiring Saccharomyces cerevisiae YNL277W increase Deletion of MET2, which causes cells to be fully impaired in their methionine synthesis and thus strictly dependent on externally supplied methionine, results in both longer maximum and median chronological lifespan. The experiment was performed in synthetic complete medium supplemented with 30 mg/l methionine, and the MET2 strain showed equivalent cell counts and comparable cell cycle arrest with the controls and MET17 strain. anti 115 100 Deletion 3475: Ruckenstuhl et al. (2014) "Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification." PLoS Genet. 10(5):e1004347 (24785424) 1974 853602 MET5 sulfite reductase (NADPH) subunit beta Saccharomyces cerevisiae ECM17 decrease Deletion of MET5 decreases lifespan. fitness Deletion 3479: Hine et al. (2015) "Endogenous hydrogen sulfide production is essential for dietary restriction benefits." Cell 160(1-2):132-144 (25542313) 1090 856825 MET6 METhionine requiring Saccharomyces cerevisiae YER091C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1091 853408 MHP1 MAP-Homologous Protein Saccharomyces cerevisiae YJL042W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2077 852848 MIG1 transcription factor MIG1 Saccharomyces cerevisiae CAT4 SSN1 TDS22 decrease Multi-copy expression of MIG-1 anti Overexpression 3578: Harkness et al. (2004) "A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast." Genetics 168(2):759-774 (15514051) 1556 853540 MIR1 Mir1p Saccharomyces cerevisiae YJR077C increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1248 852378 MIS1 MItochondrial C1-tetrahydrofolate Synthase Saccharomyces cerevisiae YBR084W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1092 854406 MKK1 Mitogen-activated protein Kinase-Kinase Saccharomyces cerevisiae YOR231W SSP32 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1093 855648 MKS1 Multicopy Kinase Suppressor Saccharomyces cerevisiae YNL076W LYS80 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1093 855648 MKS1 Multicopy Kinase Suppressor Saccharomyces cerevisiae YNL076W LYS80 increase Deletion of MKS1 results in an increase in chronological lifespan. anti Deletion 3536: Friis et al. (2014) "Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells." Cell Rep 7(2):565-574 (24726357) 1249 854532 MNE1 Mne1p Saccharomyces cerevisiae YOR350C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 2139 856718 MNN1 alpha-1,3-mannosyltransferase MNN1 Saccharomyces cerevisiae increase Deletion of MNN1 in yeast increased mean replicative lifespan. anti 15 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 2140 852303 MNN2 alpha-1,2-mannosyltransferase MNN2 Saccharomyces cerevisiae increase Deletion of MNN2 in yeast increased mean replicative lifespan. anti 16 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1513 853595 MNS1 Mns1p Saccharomyces cerevisiae YJR131W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1094 852231 MOH1 Moh1p Saccharomyces cerevisiae YBL049W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1250 855420 MON2 MONensin sensitivity Saccharomyces cerevisiae YNL297C YSL2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1915 852800 MPC1 Mpc1p Saccharomyces cerevisiae FMP37 decrease Deletion of ACH1 reduces chronological lifespan. fitness Deletion 3522: Eisenberg et al. (2014) "Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan." Cell Metab. 19(3):431-444 (24606900) 1864 854462 MPD1 protein disulfide isomerase MPD1 Saccharomyces cerevisiae increase Deletion of mpd1, a target of the unfolded protein response signaling, increases replicative lifespan. anti 17 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 441 852697 MPT5 Mpt5p Saccharomyces cerevisiae YGL178W HTR1 PUF5 UTH4 increase Overexpression extended lifespan by about 25%. pro 25 Overexpression 2324: Kennedy et al. (1997) "Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae." Cell 89(3):381-391 (9150138) 441 852697 MPT5 Mpt5p Saccharomyces cerevisiae YGL178W HTR1 PUF5 UTH4 increase Overexpression of MPT5 extends replicative life span by about 20% pro 20 Overexpression 2536: Kaeberlein and Guarente (2002) "Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity." Genetics 160(1):83-95 (11805047) 441 852697 MPT5 Mpt5p Saccharomyces cerevisiae YGL178W HTR1 PUF5 UTH4 decrease Average chronological lifespan decreased by 50%. Rescued to the wt level by PKC1 overexpression fitness 50 Deletion 2539: Stewart et al. (2007) "Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway." Eukaryotic Cell 6(2):262-270 (17172436) 1369 855264 MRE11 Meiotic REcombination Saccharomyces cerevisiae YMR224C NGS1 RAD58 XRS4 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1095 852816 MRH4 Mitochondrial RNA Helicase Saccharomyces cerevisiae YGL064C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1095 852816 MRH4 Mitochondrial RNA Helicase Saccharomyces cerevisiae YGL064C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1251 851948 MRP1 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae YDR347W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1096 856295 MRP2 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae YPR166C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1252 855985 MRP51 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae YPL118W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1253 851325 MRPL11 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YDL202W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1097 855469 MRPL17 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YNL252C MRPL30 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1098 853960 MRPL20 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YKR085C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1254 855544 MRPL22 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YNL177C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1255 855231 MRPL24 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YMR193W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1256 850359 MRPL32 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YCR003W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 2129 855330 MRPL33 mitochondrial 54S ribosomal protein YmL33 Saccharomyces cerevisiae increase Deletion of MRPL33 in yeast increased mean replicative lifespan. anti 16 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1099 853684 MRPL38 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YKL170W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1099 853684 MRPL38 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YKL170W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1388 855002 MRPL39 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YML009C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1654 851160 MRPL4 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YLR439W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1654 851160 MRPL4 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YLR439W decrease Replicative lifespan decreased by 10% in the a strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 2130 855930 MRPL40 mitochondrial 54S ribosomal protein YmL40 Saccharomyces cerevisiae increase Deletion of MRPL40 in yeast increased mean replicative lifespan. anti 21 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 2131 853349 MRPL49 mitochondrial 54S ribosomal protein YmL49 Saccharomyces cerevisiae increase Deletion of MRPL49 in yeast increased mean replicative lifespan. anti 25 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1100 853135 MRPL9 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae YGR220C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1101 856094 MRPS16 Mitochondrial Ribosomal Protein, Small subunit Saccharomyces cerevisiae YPL013C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1257 854511 MRS2 Mitochondrial RNA Splicing Saccharomyces cerevisiae YOR334W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1439 853926 MRS4 Mitochondrial RNA Splicing Saccharomyces cerevisiae YKR052C decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1439 853926 MRS4 Mitochondrial RNA Splicing Saccharomyces cerevisiae YKR052C decrease Replicative lifespan decreased by 30% in the alpha strain and 40% in a strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1370 853860 MRT4 mRNA Turnover 4 Saccharomyces cerevisiae YKL009W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 2133 851692 MRX14 putative mitochondrial 54S ribosomal protein Saccharomyces cerevisiae increase Deletion of MRX14 in yeast increased mean replicative lifespan. anti 12 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1371 854063 MSH2 MutS Homolog Saccharomyces cerevisiae YOL090W PMS5 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1464 851671 MSH6 MutS Homolog Saccharomyces cerevisiae YDR097C PMS3 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 2132 855651 MSK1 lysine--tRNA ligase MSK1 Saccharomyces cerevisiae increase Deletion of MSK1 in yeast increased mean replicative lifespan. anti 12 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1102 851775 MSS116 Mitochondrial Splicing System Saccharomyces cerevisiae YDR194C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1102 851775 MSS116 Mitochondrial Splicing System Saccharomyces cerevisiae YDR194C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1103 856253 MSS18 Mitochondrial Splicing System Saccharomyces cerevisiae YPR134W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1104 851861 MSW1 Mitochondrial aminoacyl-tRNA Synthetase, tryptophan (W) Saccharomyces cerevisiae YDR268W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1104 851861 MSW1 Mitochondrial aminoacyl-tRNA Synthetase, tryptophan (W) Saccharomyces cerevisiae YDR268W decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1104 851861 MSW1 Mitochondrial aminoacyl-tRNA Synthetase, tryptophan (W) Saccharomyces cerevisiae YDR268W increase Replicative lifespan increased by 10% in the alpha strain and in a strain anti 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1105 853319 MTC1 Maintenance of Telomere Capping Saccharomyces cerevisiae YJL123C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 775 852557 MTC4 Mtc4p Saccharomyces cerevisiae YBR255W increase Deletion increased mean replicative lifespan by 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 775 852557 MTC4 Mtc4p Saccharomyces cerevisiae YBR255W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 775 852557 MTC4 Mtc4p Saccharomyces cerevisiae YBR255W increase Replicative lifespan increased by 30% in the alpha and a strains anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1580 851706 MTC5 Maintenance of Telomere Capping Saccharomyces cerevisiae YDR128W SEA3 decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1258 856678 MTC7 Maintenance of Telomere Capping Saccharomyces cerevisiae YEL033W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1398 853955 MTD1 Methylene Tetrahydrafolate Dehydrogenase Saccharomyces cerevisiae YKR080W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1708 853173 MTM1 Manganese Trafficking factor for Mitochondrial SOD2 Saccharomyces cerevisiae YGR257C increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1708 853173 MTM1 Manganese Trafficking factor for Mitochondrial SOD2 Saccharomyces cerevisiae YGR257C decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1106 852616 MTO1 Mitochondrial Translation Optimization Saccharomyces cerevisiae YGL236C IPS1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2022 855126 MUB1 Mub1p Saccharomyces cerevisiae increase Mub1 mutants exhibit increased replicative lifespan. anti 29 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1399 852348 MUM2 MUddled Meiosis Saccharomyces cerevisiae YBR057C increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 450 856765 MXR1 Mxr1p Saccharomyces cerevisiae YER042W increase Deletion of MsrA decreases and overexpression increases (by 25%) the lifespan. pro 25 Overexpression 1092: Koc et al. (2004) "Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging." Proc. Natl. Acad. Sci. U.S.A. 101(21):7999-8004 (15141092) 450 856765 MXR1 Mxr1p Saccharomyces cerevisiae YER042W decrease Replicative lifespan decreased pro Deletion 2512: Le et al. (2009) "Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae." J. Biol. Chem. 284(7):4354-4364 (19049972) 1259 851098 NAM2 Nuclear Accommodation of Mitochondria Saccharomyces cerevisiae YLR382C MSL1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 2149 855091 NAT4 Nat4p Saccharomyces cerevisiae increase Under normal conditions downregulation of NAT4 in yeast increased mean replicative lifespan by 21%. When yeast cells lacking NAT4 were subjected to calorie restriction (0.1% glucose versus 2% glucose) no further lifespan extension was displayed, lifespan was comparable to wild type cells under calorie restriction and yeast cells lacking NAT4 under normal conditions. anti 21 RNA interference 4381: Molina-Serrano et al. (2016) "Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity." EMBO Rep. 17(12):1829-1843 (27799288) 1465 856101 NCR1 Niemann-pick type C Related Saccharomyces cerevisiae YPL006W decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 455 855176 NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae YMR145C NDH1 increase Overexpression of Nde1 and Nde2 resulted in a longer replicative lifespan (20-25%) on 2% glucose, but not on 0.5% glucose. pro 25 Overexpression 2329: Lin et al. (2004) "Calorie restriction extends yeast life span by lowering the level of NADH." Genes Dev. 18(1):12-16 (14724176) 455 855176 NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae YMR145C NDH1 increase Chronological lifespan extension anti Deletion 2330: Li et al. (2006) "Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging." Mol. Biol. Cell 17(4):1802-1811 (16436509) 456 851474 NDE2 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae YDL085W NDH2 increase Overexpression of Nde1 and Nde2 resulted in a longer replicative lifespan (20-25%) on 2% glucose, but not on 0.5% glucose. pro 25 Overexpression 2329: Lin et al. (2004) "Calorie restriction extends yeast life span by lowering the level of NADH." Genes Dev. 18(1):12-16 (14724176) 457 854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae YML120C increase Deletion results in chronological lifespan extension. anti Deletion 2330: Li et al. (2006) "Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging." Mol. Biol. Cell 17(4):1802-1811 (16436509) 457 854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae YML120C increase Targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity. pro 21 Overexpression 3282: Bahadorani et al. (2010) "Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan." Aging Cell 9(2):191-202 (20089120) 457 854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae YML120C decrease Expression of Ndi1 in adipose tissue resulted in shortened lifespan in both male and female flies. anti 22 Overexpression 3282: Bahadorani et al. (2010) "Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan." Aging Cell 9(2):191-202 (20089120) 457 854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae YML120C increase Expression of yeast Ndi1 in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends median lifespan. This effect was consistently seen in fly females, but depends on the conditions and expression system in males. Additionally to the lifespan effect, flies expressing Ndi1 have an increased feeding behavior and display weight gain. pro 30 Overexpression 3511: Hur et al. (2013) "Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells." Aging (Albany NY) 5(9):662-681 (24038661) 1739 856524 NDT80 Ndt80p Saccharomyces cerevisiae YHR124W increase Transient NDT80 expression extends the replicative life span of vegetatively growing aged cells. pro Transient expression 2541: Unal et al. (2011) "Gametogenesis eliminates age-induced cellular damage and resets life span in yeast." Science 332(6037):1554-1557 (21700873) 1892 855875 NEW1 New1p Saccharomyces cerevisiae Deletion of NEW1 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1315 853826 NFU1 NifU-like protein Saccharomyces cerevisiae YKL040C NUB1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1107 855929 NIP100 Nuclear ImPort Saccharomyces cerevisiae YPL174C PAC13 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1669 855600 NMA111 Nuclear Mediator of Apoptosis Saccharomyces cerevisiae YNL123W YNM3 increase Increased chronological lifespan pro Overexpression 2517: Walter et al. (2006) "The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2." J. Cell. Sci. 119(Pt 9):1843-1851 (16608876) 1260 856476 NMD2 Nonsense-mediated MRNA Decay Saccharomyces cerevisiae YHR077C IFS1 SUA1 SUP111 UPF2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1641 851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae YLR363C increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1641 851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae YLR363C decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1641 851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae YLR363C increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1641 851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae YLR363C decrease Replicative lifespan decreased by 20% in a strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1672 850892 NMT1 N-Myristoyl Transferase Saccharomyces cerevisiae YLR195C CDC72 increase Replicative lifespan increased by 50% anti 50 Deletion 2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (10921902) 1518 853683 NNK1 Nitrogen Network Kinase Saccharomyces cerevisiae YKL171W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1372 852042 NPL3 Nuclear Protein Localization Saccharomyces cerevisiae YDR432W MTR13 MTS1 NAB1 NOP3 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1372 852042 NPL3 Nuclear Protein Localization Saccharomyces cerevisiae YDR432W MTR13 MTS1 NAB1 NOP3 decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 470 854384 NPT1 Nicotinatephosphoribosyltranfserase Saccharomyces cerevisiae YOR209C increase Increased dosage increases sir2-dependent silencing and extends yeast replicative lifespan by up to 60%. pro 60 Increased dosage 2335: Anderson et al. (2002) "Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels." J. Biol. Chem. 277(21):18881-18890 (11884393) 470 854384 NPT1 Nicotinatephosphoribosyltranfserase Saccharomyces cerevisiae YOR209C decrease Chronological lifespan decreased pro Deletion 2510: Tahara et al. (2007) "Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging." FASEB J. 21(1):274-283 (17110466) 470 854384 NPT1 Nicotinatephosphoribosyltranfserase Saccharomyces cerevisiae YOR209C decrease Replicative lifespan decreased by 50% fitness 50 Deletion 2550: Belenky et al. (2007) "Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+." Cell 129(3):473-484 (17482543) 1416 855594 NRK1 Nicotinamide Riboside Kinase Saccharomyces cerevisiae YNL129W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1482 853064 NSR1 Nsr1p Saccharomyces cerevisiae YGR159C SHE5 decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1709 855633 NST1 Negatively affects Salt Tolerance Saccharomyces cerevisiae YNL091W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1709 855633 NST1 Negatively affects Salt Tolerance Saccharomyces cerevisiae YNL091W decrease Replicative lifespan decreased by 30% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1626 851564 NTH1 Neutral TreHalase Saccharomyces cerevisiae YDR001C decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1466 852199 NUP170 NUclear Pore Saccharomyces cerevisiae YBL079W NLE3 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1666 850782 NYV1 New Yeast V-SNARE Saccharomyces cerevisiae YLR093C MAM2 decrease Replicative lifespan decreased by 50% on CR medium fitness 50 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1568 854670 OM45 Outer Membrane Saccharomyces cerevisiae YIL136W increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1602 853962 OMA1 Overlapping activity with M-AAA protease Saccharomyces cerevisiae YKR087C decrease Replicative lifespan decreased by 70% in the alpha strain fitness 70 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1108 853536 OPI3 OverProducer of Inositol Saccharomyces cerevisiae YJR073C PEM2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1743 856324 OPT2 OligoPeptide Transporter 2 Saccharomyces cerevisiae YPR194C increase OPT2 deletion increases mean and maximum replicative lifespan under ad libitum. This is not further extended by dietary restriction. anti 9 23 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1109 851543 OSH2 OxySterol binding protein Homolog Saccharomyces cerevisiae YDL019C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1840 853872 OSH6 oxysterol-binding protein OSH6 Saccharomyces cerevisiae increase In YEPD medium, the replicative lifespan of PERG6-OSH6 (mean 37.1, median 38) was significantly longer than the lifespan of the wild type control. pro 20 23 Overexpression 3273: Gebre et al. (2012) "Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion." Cell Cycle 11(11):2176-2188 (22622083) 1868 854252 OST3 dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Saccharomyces cerevisiae increase Deletion of ost3, a target of the unfolded protein response signaling, increases replicative lifespan. anti 20 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1110 851643 PAA1 PolyAmine Acetyltransferase Saccharomyces cerevisiae YDR071C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1110 851643 PAA1 PolyAmine Acetyltransferase Saccharomyces cerevisiae YDR071C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1389 852969 PAC10 Protein required in the Absence of Cin8p Saccharomyces cerevisiae YGR078C GIM2 PFD3 RKS2 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1111 856662 PAU2 seriPAUperin family Saccharomyces cerevisiae YEL049W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1112 852598 PCA1 P-type Cation-transporting ATPase Saccharomyces cerevisiae YBR295W CAD2 PAY2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1536 852484 PCH2 Pachytene CHeckpoint Saccharomyces cerevisiae YBR186W increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1679 853972 PCK1 Phosphoenolpyruvate CarboxyKinase Saccharomyces cerevisiae YKR097W JPM2 PPC1 decrease Mean chronological lifespan decreased in the alpha strain fitness Deletion 2526: Lin et al. (2009) "Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis." Cell 136(6):1073-1084 (19303850) 1113 856787 PCL6 Pho85 CycLin Saccharomyces cerevisiae YER059W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1347 854761 PCL7 Pho85 CycLin Saccharomyces cerevisiae YIL050W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1114 852993 PCP1 Processing of Cytochrome c Peroxidase Saccharomyces cerevisiae YGR101W MDM37 RBD1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1390 856925 PDA1 Pyruvate Dehydrogenase Alpha Saccharomyces cerevisiae YER178W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1115 850733 PDC1 Pyruvate DeCarboxylase Saccharomyces cerevisiae YLR044C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1116 854542 PDE2 PhosphoDiEsterase Saccharomyces cerevisiae YOR360C SRA5 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1116 854542 PDE2 PhosphoDiEsterase Saccharomyces cerevisiae YOR360C SRA5 decrease Replicative lifespan decreased fitness Deletion 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 1348 855807 PDR18 Pleiotropic Drug Resistance Saccharomyces cerevisiae YNR070W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1572 852323 PDX3 PyriDoXine auxotrophy Saccharomyces cerevisiae YBR035C increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1497 854201 PEP12 carboxyPEPtidase Y-deficient Saccharomyces cerevisiae YOR036W VPL6 VPS6 VPT13 decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1117 855299 PET111 PETite colonies Saccharomyces cerevisiae YMR257C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1118 852198 PET112 PETite colonies Saccharomyces cerevisiae YBL080C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1118 852198 PET112 PETite colonies Saccharomyces cerevisiae YBL080C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1261 856786 PET117 PETite colonies Saccharomyces cerevisiae YER058W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1838 854182 PET127 Pet127p Saccharomyces cerevisiae increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 35 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1839 850756 PET309 Pet309p Saccharomyces cerevisiae increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 25 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1595 852250 PET9 PETite colonies Saccharomyces cerevisiae YBL030C AAC2 ANC2 decrease Replicative lifespan decreased by 30% pro 30 Mutation 2506: Wang et al. (2008) "Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases." Hum. Mol. Genet. 17(24):4036-4044 (18809618) 1262 852724 PEX14 PEroXisome related Saccharomyces cerevisiae YGL153W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1263 853219 PEX2 PEroXin Saccharomyces cerevisiae YJL210W CRT1 PAS5 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1514 855991 PEX25 PEroXisome related Saccharomyces cerevisiae YPL112C increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1119 851831 PEX5 PEroXin Saccharomyces cerevisiae YDR244W PAS10 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1120 855387 PEX6 PEroXin Saccharomyces cerevisiae YNL329C PAS8 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1498 855390 PFA3 Protein Fatty Acyltransferase Saccharomyces cerevisiae YNL326C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1417 852070 PFA5 Protein Fatty Acyltransferase Saccharomyces cerevisiae YDR459C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1678 854914 PGA3 Processing of Gas1p and ALP Saccharomyces cerevisiae YML125C NQR1 increase Replicative and chronological lifespan extended by 20-30% lifespan pro 30 Overexpression 2525: Jiménez-Hidalgo et al. (2009) "NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast." Aging Cell 8(2):140-151 (19239415) 504 853033 PHB1 Phb1p Saccharomyces cerevisiae YGR132C decrease Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential. fitness Deletion 2341: Coates et al. (1997) "The prohibitin family of mitochondrial proteins regulate replicative lifespan." Curr. Biol. 7(8):607-610 (9259555) 504 853033 PHB1 Phb1p Saccharomyces cerevisiae YGR132C decrease Replicative lifespan decreased by 20% pro 20 Deletion 2535: Piper et al. (2002) "The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells." Aging Cell 1(2):149-157 (12882345) 505 853146 PHB2 Phb2p Saccharomyces cerevisiae YGR231C decrease Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential. fitness Deletion 2341: Coates et al. (1997) "The prohibitin family of mitochondrial proteins regulate replicative lifespan." Curr. Biol. 7(8):607-610 (9259555) 505 853146 PHB2 Phb2p Saccharomyces cerevisiae YGR231C Two classes of prohibitin dependent mutation (pbd1 and pbd2) were isolated and characterised. The effect of these mutations on replicative lifespan was determined, demonstrating that the pbd1 mutant slightly extended lifespan by 11%, whereas in contrast, the pbd2 mutation resulted in a shortening in both the mean- and the maximum-lifespan by (28 and 17%, respectively). The pbd1 mutation was also found to reduce chronological lifespan. Reducing the expression of the PHB2 gene in the pbd mutants was found to retard the rate of growth and to affect replicative lifespan. As the two mutants behave in a different manner they probably affect different aspects of prohibitin function. Mutation 2533: Liu and Jamieson (2006) "Isolation of mutations synthetic-lethal to prohibitin 2 null mutants of Saccharomyces cerevisiae." Antonie Van Leeuwenhoek 89(2):281-292 (16710639) 505 853146 PHB2 Phb2p Saccharomyces cerevisiae YGR231C decrease Replicative lifespan decreased by 30% pro 30 Deletion 2535: Piper et al. (2002) "The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells." Aging Cell 1(2):149-157 (12882345) 1643 853823 PHD1 PseudoHyphal Determinant Saccharomyces cerevisiae YKL043W increase Replicative lifespan increased by 10-20% in the alpha and a strains anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1316 851452 PHO2 PHOsphate metabolism Saccharomyces cerevisiae YDL106C BAS2 GRF10 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1316 851452 PHO2 PHOsphate metabolism Saccharomyces cerevisiae YDL106C BAS2 GRF10 decrease Replicative lifespan decreased by 25% in the a strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1264 855626 PHO23 PHOsphate metabolism Saccharomyces cerevisiae YNL097C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 2111 854916 PHO84 phosphate transporter PHO84 Saccharomyces cerevisiae increase The retrograde response is activated in response to mitochondrial dysfunction and extends replicative lifespan. Rho- yeast cells have petite mitochondria and cannot support normal oxidative phosphorylation. Deletion of PHO84 in rho- cells completely abrogated replicative lifespan extension. Overexpression of PHO84 in rho+ cells increased mean replicative lifespan by 14%. In rho- cells mean replicative lifespan was increased by 37%. pro 14 Overexpression 4412: Jiang et al. (2016) "Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae." Genetics 204(2):659-673 (27474729) 1317 856076 PHO85 PHOsphate metabolism Saccharomyces cerevisiae YPL031C LDB15 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1317 856076 PHO85 PHOsphate metabolism Saccharomyces cerevisiae YPL031C LDB15 decrease Replicative lifespan decreased by 45% in the alpha strain fitness 45 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1537 852599 PHO89 PHOsphate metabolism Saccharomyces cerevisiae YBR296C ITN1 increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1545 851908 PIB1 PhosphatidylInositol(3)-phosphate Binding Saccharomyces cerevisiae YDR313C increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1545 851908 PIB1 PhosphatidylInositol(3)-phosphate Binding Saccharomyces cerevisiae YDR313C increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1467 852259 PIM1 Proteolysis In Mitochondria Saccharomyces cerevisiae YBL022C decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1557 856277 PIN3 Psi+ INducibility Saccharomyces cerevisiae YPR154W LSB2 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1558 852101 PKH1 Pkb-activating Kinase Homolog Saccharomyces cerevisiae YDR490C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1710 854053 PKH2 Pkb-activating Kinase Homolog Saccharomyces cerevisiae YOL100W increase Replicative lifespan increased by 20% in the alpha strain and increased by 15% in the a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1655 852077 PKH3 Pkb-activating Kinase Homolog Saccharomyces cerevisiae YDR466W increase Replicative lifespan increased by 10% in the alpha strain anti 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1121 850389 PMP1 Plasma Membrane Proteolipid Saccharomyces cerevisiae YCR024C-A decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1122 851869 PMP3 Plasma Membrane Proteolipid Saccharomyces cerevisiae YDR276C SNA1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1711 852709 PMR1 Plasma Membrane ATPase Related Saccharomyces cerevisiae YGL167C BSD1 LDB1 SSC1 increase Replicative lifespan increased by 40% in the alpha strain and increased by 15% in the a strain anti 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1318 855642 PMS1 PostMeiotic Segregation Saccharomyces cerevisiae YNL082W decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1123 851462 PMT1 Protein O-MannosylTransferase Saccharomyces cerevisiae YDL095W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2141 851464 PMT5 putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 Saccharomyces cerevisiae increase Deletion of PMT5 in yeast increased mean replicative lifespan. anti 21 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1521 851902 PMT7 Pmt7p Saccharomyces cerevisiae YDR307W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1015 852846 PNC1 Pyrazinamidase and NiCotinamidase Saccharomyces cerevisiae YGL037C increase Increased expression of PNC1 is both necessary and sufficient for replicative lifespan extension by calorie restriction and low-intensity stress. under non-stressing conditions (2% glucose, 30C), a strain with additional copies of PNC1 (5XPNC1) had 70% longer replicative lifespan than the wild type and some cells lived for more than 70 divisions.Neither calorie restriction nor heat stress further increased the lifespan of the 5XPNC1 strain. pro 70 Overexpression 2499: Anderson et al. (2003) "Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae." Nature 423(6936):181-185 (12736687) 1015 852846 PNC1 Pyrazinamidase and NiCotinamidase Saccharomyces cerevisiae YGL037C decrease Chronological lifespan decreased pro Deletion 2510: Tahara et al. (2007) "Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging." FASEB J. 21(1):274-283 (17110466) 1015 852846 PNC1 Pyrazinamidase and NiCotinamidase Saccharomyces cerevisiae YGL037C increase PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression. pro Overexpression 2524: Gallo et al. (2004) "Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity." Mol. Cell. Biol. 24(3):1301-1312 (14729974) 1124 854440 PNT1 PeNTamidine resistance Saccharomyces cerevisiae YOR266W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1319 854684 POG1 Promoter Of Growth Saccharomyces cerevisiae YIL122W decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1265 855309 PPA2 PyroPhosphatAse Saccharomyces cerevisiae YMR267W IPP2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1391 851647 PPH3 Protein PHosphatase Saccharomyces cerevisiae YDR075W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1125 854992 PPZ1 Protein Phosphatase Z Saccharomyces cerevisiae YML016C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2020 853036 PRE9 proteasome core particle subunit alpha 3 Saccharomyces cerevisiae decrease Pre9 mutants exhibit reduced replicative lifespan. fitness 20 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1526 854713 PRK1 p53 Regulatory Kinase Saccharomyces cerevisiae YIL095W PAK1 increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1573 856375 PRS3 PhosphoRibosylpyrophosphate Synthetase Saccharomyces cerevisiae YHL011C increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1126 852215 PRX1 PeroxiRedoXin Saccharomyces cerevisiae YBL064C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1126 852215 PRX1 PeroxiRedoXin Saccharomyces cerevisiae YBL064C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1468 853366 PRY1 Pathogen Related in Yeast Saccharomyces cerevisiae YJL079C decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1127 855552 PSD1 PhosphatidylSerine Decarboxylase Saccharomyces cerevisiae YNL169C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1861 851596 PST2 Pst2p Saccharomyces cerevisiae increase Deletion of pst2 extends chronological mean and maximum lifespan. anti 25 36 Deletion 3491: Borklu Yucel and Ulgen (2011) "A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae." PLoS ONE 6(12):e29284 (22216232) 1373 854257 PTC5 Phosphatase Two C Saccharomyces cerevisiae YOR090C PPP1 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1128 856596 PTH1 Peptidyl-Trna Hydrolase Saccharomyces cerevisiae YHR189W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1129 853522 PTK2 Putative serine/Threonine protein Kinase Saccharomyces cerevisiae YJR059W STK2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1499 855716 PUB1 PolyUridylate Binding Saccharomyces cerevisiae YNL016W RNP1 decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1266 851132 PUN1 Plasma membrane protein Upregulated during Nitrogen stress Saccharomyces cerevisiae YLR414C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1515 853965 PXL1 PaXillin-Like protein Saccharomyces cerevisiae YKR090W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1130 852142 QCR7 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae YDR529C COR4 CRO1 UCR7 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1130 852142 QCR7 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae YDR529C COR4 CRO1 UCR7 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1131 853273 QCR8 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae YJL166W COR5 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1267 850901 QRI5 Qri5p Saccharomyces cerevisiae YLR204W COX24 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1268 854878 RAD10 RADiation sensitive Saccharomyces cerevisiae YML095C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 531 853747 RAD27 Rad27p Saccharomyces cerevisiae YKL113C ERC11 FEN1 RTH1 decrease Mutations result in signs of premature ageing. pro Mutations 1425: Hoopes et al. (2002) "Mutations in DNA replication genes reduce yeast life span." Mol. Cell. Biol. 22(12):4136-4146 (12024027) 531 853747 RAD27 Rad27p Saccharomyces cerevisiae YKL113C ERC11 FEN1 RTH1 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1686 851909 RAD34 Homologous to RAD4 Saccharomyces cerevisiae YDR314C increase Replicative lifespan increased by 30% in the a strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1269 856909 RAD4 RADiation sensitive Saccharomyces cerevisiae YER162C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 532 855471 RAD50 Subunit of MRX complex, with Mre11p and Xrs2p Saccharomyces cerevisiae YNL250W decrease Mutations result in a 70% reduced lifespan. fitness 70 Mutations 192: Park et al. (1999) "Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae." Mol. Cell. Biol. 19(5):3848-3856 (10207108) 533 856831 RAD51 Strand exchange protein Saccharomyces cerevisiae YER095W MUT5 decrease Mutations result in a 40% reduced lifespan. fitness 40 Mutations 192: Park et al. (1999) "Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae." Mol. Cell. Biol. 19(5):3848-3856 (10207108) 534 854976 RAD52 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) Saccharomyces cerevisiae YML032C decrease Mutations result in a 70% reduced lifespan. fitness 70 Mutations 192: Park et al. (1999) "Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae." Mol. Cell. Biol. 19(5):3848-3856 (10207108) 1132 851648 RAD55 RADiation sensitive Saccharomyces cerevisiae YDR076W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1132 851648 RAD55 RADiation sensitive Saccharomyces cerevisiae YDR076W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1132 851648 RAD55 RADiation sensitive Saccharomyces cerevisiae YDR076W decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 535 851567 RAD57 Rad57p Saccharomyces cerevisiae YDR004W decrease Mutations result in a 40% reduced lifespan. fitness 40 Mutations 192: Park et al. (1999) "Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae." Mol. Cell. Biol. 19(5):3848-3856 (10207108) 536 851803 RAD9 Rad9p Saccharomyces cerevisiae YDR217C decrease Deletion results in mutants with a 2-fold decrease in mean and maximum chronological lifespan under conditions of nutrient depletion. fitness 50 Deletion 2267: Weinberger et al. (2007) "DNA replication stress is a determinant of chronological lifespan in budding yeast." PLoS ONE 2(8):e748 (17710147) 539 854268 RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway Saccharomyces cerevisiae YOR101W increase Deletion increased mean (23%) and maximum (29%) lifespan. anti 29 23 Deletion 342: Sun et al. (1994) "Divergent roles of RAS1 and RAS2 in yeast longevity." J. Biol. Chem. 269(28):18638-18645 (8034612) 539 854268 RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway Saccharomyces cerevisiae YOR101W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 540 855625 RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr Saccharomyces cerevisiae YNL098C CTN5 CYR3 GLC5 TSL7 increase Overexpression of a mutant gene caused a 43% increase in mean and 18% increase in maximum lifespan. pro 18 43 Overexpression 342: Sun et al. (1994) "Divergent roles of RAS1 and RAS2 in yeast longevity." J. Biol. Chem. 269(28):18638-18645 (8034612) 540 855625 RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr Saccharomyces cerevisiae YNL098C CTN5 CYR3 GLC5 TSL7 increase Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean life span by a mechanism that requires Msn2/4 and Sod2 anti Deletion 2271: Fabrizio et al. (2003) "SOD2 functions downstream of Sch9 to extend longevity in yeast." Genetics 163(1):35-46 (12586694) 1133 853490 RAV1 Regulator of (H+)-ATPase in Vacuolar membrane Saccharomyces cerevisiae YJR033C SOI3 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1855 855709 RCM1 Rcm1p Saccharomyces cerevisiae increase Deletion of RCM1 in haploid S. cerevisiae increases chronological lifespan in water and in SC spent medium. Replicative lifespan was however reduced. anti Deletion 3488: Schosserer et al. (2015) "Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan." Nat Commun 6:6158 (25635753) 1744 851566 RCR2 Resistance to Congo Red 2 Saccharomyces cerevisiae YDR003W SSH5 increase RCR2 deletion extends mean replicative lifespan under ad libitum. This is not further extended by dietary restriction. anti 18 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1884 853226 RCY1 Rcy1p Saccharomyces cerevisiae increase Deletion of RCY1 increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1933 856115 REC8 Rec8p Saccharomyces cerevisiae SPO69 increase Deletion of REC8 (ortholog of the REC-8 nematode gene) can extend the replicative lifespan of yeast. anti 20 Deletion 3535: Ayyadevara et al. (2014) "Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae." Front Genet 5:211 (25136348) 1934 851592 REG1 protein phosphatase regulator REG1 Saccharomyces cerevisiae HEX2 PZF240 SPP43 SRN1 decrease Deletion of REG1 results in a decrease in chronological lifespan. fitness Deletion 3536: Friis et al. (2014) "Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells." Cell Rep 7(2):565-574 (24726357) 544 852569 REI1 Cytoplasmic pre-60S factor Saccharomyces cerevisiae YBR267W increase Deletion increased mean replicative lifespan by about 40%. anti 40 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 544 852569 REI1 Cytoplasmic pre-60S factor Saccharomyces cerevisiae YBR267W increase Replicative lifespan increased by 40% in the alpha and a strains anti 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1456 850873 RFX1 Rfx1p Saccharomyces cerevisiae YLR176C CRT1 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1591 854274 RGS2 Regulator of heterotrimeric G protein Signaling Saccharomyces cerevisiae YOR107W increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1400 853828 RGT1 Restores Glucose Transport Saccharomyces cerevisiae YKL038W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1401 851417 RGT2 Restores Glucose Transport Saccharomyces cerevisiae YDL138W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1134 855541 RHO5 Ras HOmolog Saccharomyces cerevisiae YNL180C YNS0 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1590 852578 RIF1 RAP1-Interacting Factor Saccharomyces cerevisiae YBR275C decrease Replicative lifespan decreased by 30% pro 30 Deletion 2371: Austriaco and Guarente (1997) "Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae." Proc. Natl. Acad. Sci. U.S.A. 94(18):9768-9772 (9275199) 1644 850395 RIM1 Replication In Mitochondria Saccharomyces cerevisiae YCR028C-A increase Replicative lifespan increased by 10-20% in the alpha and a strains anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1320 855170 RIM11 Regulator of IME2 Saccharomyces cerevisiae YMR139W GSK3 MDS1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 551 850511 RIM15 Regulator of IME2 Saccharomyces cerevisiae YFL033C TAK1 decrease Deletion reduced maximal chronological lifespan by 50%. fitness 50 Deletion 2346: Fabrizio et al. (2001) "Regulation of longevity and stress resistance by Sch9 in yeast." Science 292(5515):288-290 (11292860) 551 850511 RIM15 Regulator of IME2 Saccharomyces cerevisiae YFL033C TAK1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1135 852837 RIM8 Regulator of IME2 Saccharomyces cerevisiae YGL045W ART9 PAL3 YGL046W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1135 852837 RIM8 Regulator of IME2 Saccharomyces cerevisiae YGL045W ART9 PAL3 YGL046W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1559 856689 RIP1 Rieske Iron-sulfur Protein Saccharomyces cerevisiae YEL024W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1136 855289 RKR1 RING domain mutant Killed by rtf1 deletion Saccharomyces cerevisiae YMR247C LTN1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1137 856016 RLM1 Resistance to Lethality of MKK1P386 overexpression Saccharomyces cerevisiae YPL089C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1138 850609 RMD8 Required for Meiotic nuclear Division Saccharomyces cerevisiae YFR048W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1139 852771 RMD9 Required for Meiotic nuclear Division Saccharomyces cerevisiae YGL107C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1574 855652 RNH201 RNase H Saccharomyces cerevisiae YNL072W RNH35 increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1374 854744 RNR3 RiboNucleotide Reductase Saccharomyces cerevisiae YIL066C DIN1 RIR3 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 554 851086 ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p Saccharomyces cerevisiae YLR371W increase Deletion increased mean replicative lifespan by about 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 554 851086 ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p Saccharomyces cerevisiae YLR371W increase Replicative lifespan increased by 50% in the alpha strain and 20% in a strain anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1202 855300 ROY1 Repressor Of Ypt52 Saccharomyces cerevisiae YMR258C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 555 855386 RPD3 Histone deacetylase Saccharomyces cerevisiae YNL330C MOF6 REC3 SDI2 SDS6 increase Deletion extended lifespan by 41%, independently of an intact Sir silencing complex. anti 41 Deletion 203: Kim et al. (1999) "Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae." Mol. Biol. Cell 10(10):3125-3136 (10512855) 561 850764 RPL10 ribosomal 60S subunit protein L10 Saccharomyces cerevisiae YLR075W GRC5 QSR1 increase Heterozygosity for rpl10D increased median replicative lifespan by 24%. anti 24 Knockout 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 1593 856656 RPL12A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YEL054C increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1459 852026 RPL12B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YEL054C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1528 851477 RPL13A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YDL082W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1469 855173 RPL13B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YMR142C decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 2122 855655 RPL16B ribosomal 60S subunit protein L16B Saccharomyces cerevisiae increase Deletion of RPL16B in yeast increased mean replicative lifespan. anti 23 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1503 853262 RPL17B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YJL177W decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1656 852379 RPL19A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBL027W increase Replicative lifespan increased by 30% in the alpha strain and 50% in a strain anti 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1656 852379 RPL19A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBL027W increase Replicative lifespan increased by 30% in the alpha strain and 50% in a strain anti 50 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1457 852254 RPL19B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBL027W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1457 852254 RPL19B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBL027W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1460 852742 RPL1B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YPL220W SSM2 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1603 855283 RPL20A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YOR312C RPL18A2 decrease Replicative lifespan decreased by 40% in the a strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1603 855283 RPL20A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YOR312C RPL18A2 decrease Replicative lifespan decreased by 40% in the a strain fitness 40 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1687 854489 RPL20B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YOR312C RPL18A1 increase Replicative lifespan increased by 40%-50% in the alpha and a strains anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1687 854489 RPL20B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YOR312C RPL18A1 increase Replicative lifespan increased by 35%-50% in the alpha and a strains anti 50 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1529 852489 RPL21A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBR191W URP1 increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1723 856026 RPL21B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YPL079W increase Replicative lifespan increased by 50%-40% in the alpha and a strains anti 50 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1724 850750 RPL22A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YLR061W increase Replicative lifespan increased by 40%-90% in the alpha and a strains anti 90 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1725 852191 RPL23A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YER117W increase Replicative lifespan increased by 40%-40% in the alpha and a strains anti 40 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 2123 851058 RPL26A ribosomal 60S subunit protein L26A Saccharomyces cerevisiae increase Deletion of RPL26A in yeast increased mean replicative lifespan. anti 22 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1726 850592 RPL29 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YFR032C-A increase Replicative lifespan increased by 20%-35% in the alpha and a strains anti 35 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 2124 854794 RPL2B ribosomal 60S subunit protein L2B Saccharomyces cerevisiae increase Deletion of RPL2B in yeast increased mean replicative lifespan. anti 38 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 562 851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae YDL075W RPL34 increase Deletion increased mean replicative lifespan by 45%. anti 45 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 562 851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae YDL075W RPL34 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 562 851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae YDL075W RPL34 increase RPL31A and RPL6B were found to increase significantly yeast replicative life span (RLS). anti Deletion 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 562 851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae YDL075W RPL34 increase Replicative lifespan increased by 35% in the alpha strain and 50% in a strain anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 562 851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae YDL075W RPL34 increase Replicative lifespan increased by 35% in the alpha strain and 50% in a strain anti 50 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1561 854409 RPL33B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YOR234C RPL37B increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1504 856784 RPL34A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YER056C-A decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1727 854759 RPL34B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YIL052C increase Replicative lifespan increased by 30% in the alpha strain and 60% in a strain anti 60 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 2125 851336 RPL35A ribosomal 60S subunit protein L35A Saccharomyces cerevisiae increase Deletion of RPL35A in yeast increased mean replicative lifespan. anti 41 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1562 851419 RPL35B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YDL191W SOS2 increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1375 850882 RPL37A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YLR185W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1594 852111 RPL37B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YDR500C increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1594 852111 RPL37B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YDR500C increase Replicative lifespan increased by 35% in the alpha strain and 30% in a strain anti 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1728 853250 RPL39 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YJL189W PUB2 RPL46 SPB2 decrease Replicative lifespan decreased by 15% in the alpha strain and 45% in a strain fitness 45 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1729 856156 RPL43A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YPR043W decrease Replicative lifespan decreased by 60% in the alpha strain and by 50% in a strain fitness 60 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1730 853557 RPL43B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YPR043W increase Replicative lifespan increased by 30% in the alpha strain and by 30% in a strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1461 852319 RPL4A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBR031W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1461 852319 RPL4A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YBR031W increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1500 854902 RPL6A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YML073C YL16A decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1500 854902 RPL6A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YML073C YL16A decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 563 851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae YLR448W increase Deletion significantly increased replicative lifespan. anti Deletion 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 563 851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae YLR448W increase Replicative lifespan increased by 15% in the alpha strain and 30% in a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 563 851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae YLR448W increase Replicative lifespan increased by 15% in the alpha strain and 30% in a strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 563 851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae YLR448W increase Replicative lifespan increased by 15% in the alpha strain and 40% in a strain anti 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1731 852804 RPL7A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YGL076C increase Replicative lifespan increased by 40% in the alpha strain and 20% in a strain anti 40 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1563 850682 RPL8B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YLL045C KRB1 SCL41 increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1657 852730 RPL9A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YGL147C increase Replicative lifespan increased by 30% in the alpha strain and 20% in a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1657 852730 RPL9A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YGL147C increase Replicative lifespan increased by 30% in the alpha strain and 20% in a strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1658 855658 RPL9B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YNL067W increase Replicative lifespan increased by 30% in a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1658 855658 RPL9B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae YNL067W increase Replicative lifespan increased by 30% in a strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1140 851542 RPN4 Regulatory Particle Non-ATPase Saccharomyces cerevisiae YDL020C SON1 UFD5 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1140 851542 RPN4 Regulatory Particle Non-ATPase Saccharomyces cerevisiae YDL020C SON1 UFD5 decrease Rpn4 mutants exhibit reduced replicative lifespan. fitness 40 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 2240 854283 RPO31 RPO31 Saccharomyces cerevisiae increase Inducible depletion of RPO31 increased chronological lifespan but not replicative lifespan in yeast. anti depletion 4774: Filer et al. (2017) "RNA polymerase III limits longevity downstream of TORC1." Nature 552(7684):263-267 (29186112) 564 850507 RPO41 Rpo41p Saccharomyces cerevisiae YFL036W decrease Mutants exhibit reduced chronological lifespan accompanied by imbalanced mitochondrial translation, conditional inactivation of respiration, elevated production of reactive oxygen species, and increased oxidative stress. fitness Mutation 2349: Bonawitz et al. (2006) "Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span." Mol. Cell. Biol. 26(13):4818-4829 (16782871) 1732 851478 RPP1A Ribosomal Protein P1 Alpha Saccharomyces cerevisiae YDL081C RPLA1 decrease Replicative lifespan decreased by 20% in the alpha strain and by 30% in the a strain fitness 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1587 851427 RPP1B Ribosomal Protein P1 Beta Saccharomyces cerevisiae YDL130W RPL44' RPLA3 increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1270 854118 RPP2A Ribosomal Protein P2 Alpha Saccharomyces cerevisiae YOL039W RPL44 RPLA2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1270 854118 RPP2A Ribosomal Protein P2 Alpha Saccharomyces cerevisiae YOL039W RPL44 RPLA2 increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1733 851990 RPP2B Ribosomal Protein P2 Beta Saccharomyces cerevisiae YDR382W RPL45 YPA1 increase Replicative lifespan increased by 55% in the alpha strain and 45% in a strain anti 55 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1422 850737 RPS0B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YLR048W NAB1B YST2 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1883 855270 RPS10B ribosomal 40S subunit protein S10B Saccharomyces cerevisiae increase Deletion of RPS10B increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1606 851589 RPS11A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YDR025W increase Replicative lifespan increased by 30% in alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1606 851589 RPS11A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YDR025W increase Replicative lifespan increased by 30% in alpha strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 2126 854551 RPS12 ribosomal 40S subunit protein S12 Saccharomyces cerevisiae increase Deletion of RPS12 in yeast increased mean replicative lifespan. anti 38 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1588 854984 RPS17A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YML024W RP51A RPL51A decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 575 852061 RPS18A ribosomal 40S subunit protein S18A Saccharomyces cerevisiae YDR450W increase Deletion of both RPS18A and RPS18B paralogs increased replicative lifespan by 15%. anti 15 Deletion 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 576 854982 RPS18B ribosomal 40S subunit protein S18B Saccharomyces cerevisiae YDR450W increase Deletion of both RPS18A and RPS18B paralogs increased replicative lifespan by 15%. anti 15 Deletion 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 576 854982 RPS18B ribosomal 40S subunit protein S18B Saccharomyces cerevisiae YDR450W increase Deletion of RPS18B increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1443 854939 RPS1B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YML063W PLC2 RP10B decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1141 853305 RPS21B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YJL136C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1141 853305 RPS21B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YJL136C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1444 856805 RPS24A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YER074W RPS24EA decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1444 856805 RPS24A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YER074W RPS24EA increase Deletion of RPS24A increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1423 854741 RPS24B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YER074W RPS24EB decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1712 856868 RPS26B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YER131W increase Replicative lifespan increased by 20% in a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1424 853700 RPS27A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YKL156W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1425 856415 RPS27B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YHR021C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1425 856415 RPS27B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YHR021C decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1589 853610 RPS4A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YHR203C decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1505 856610 RPS4B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YHR203C decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 1505 856610 RPS4B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YHR203C increase Deletion of RPS4B increases yeast chronological lifespan. anti Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1607 856015 RPS6A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YPL090C increase Replicative lifespan increased by 30% in alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1607 856015 RPS6A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YPL090C increase Replicative lifespan increased by 30% in alpha strain anti 30 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 577 852479 RPS6B ribosomal 40S subunit protein S6B Saccharomyces cerevisiae YPL090C LPG18 RPS101 RPS102 increase Deletion increased mean replicative lifespan by about 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 577 852479 RPS6B ribosomal 40S subunit protein S6B Saccharomyces cerevisiae YPL090C LPG18 RPS101 RPS102 increase Deletion of the SSU RPS6B paralog, but not of the RPS6A paralog increased replicative median life span robustly by 45% anti 45 Deletion 2348: Chiocchetti et al. (2007) "Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span." Exp. Gerontol. 42(4):275-286 (17174052) 1506 854263 RPS7A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae YOR096W RPS30 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2505: Steffen et al. (2008) "Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4." Cell 133(2):292-302 (18423200) 2014 853712 RPT1 proteasome regulatory particle base subunit RPT1 Saccharomyces cerevisiae CIM5 YTA3 decrease Rpt1 mutants exhibit reduced replicative lifespan. fitness 33 Mutation 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 2015 851557 RPT2 proteasome regulatory particle base subunit RPT2 Saccharomyces cerevisiae YHS4 YTA5 decrease Rpt2 mutants exhibit reduced replicative lifespan. fitness 68 Mutation 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 2016 852003 RPT3 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae YNT1 YTA2 decrease Rpt3 mutants exhibit reduced replicative lifespan. fitness 55 Mutation 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 2017 854284 RPT5 proteasome regulatory particle base subunit RPT5 Saccharomyces cerevisiae YTA1 decrease Rpt5 mutants exhibit reduced replicative lifespan. fitness 85 Mutation 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 2018 852834 RPT6 proteasome regulatory particle base subunit RPT6 Saccharomyces cerevisiae CIM3 CRL3 SCB68 SUG1 decrease Rpt6 mutants exhibit reduced replicative lifespan. fitness 63 Mutation 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1142 855951 RRD2 Resistant to Rapamycin Deletion Saccharomyces cerevisiae YPL152W YPA2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1474 851637 RRG1 Required for Respiratory Growth Saccharomyces cerevisiae YDR065W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1271 854482 RRG7 Required for Respiratory Growth Saccharomyces cerevisiae YOR305W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1143 856232 RRG8 Required for Respiratory Growth Saccharomyces cerevisiae YPR116W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1272 855508 RRG9 Required for Respiratory Growth Saccharomyces cerevisiae YNL213C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1688 856426 RRM3 rDNA Recombination Mutation Saccharomyces cerevisiae YHR031C RTT104 decrease Replicative lifespan decreased by 30% in the alpha and a strains fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1893 851656 RRP8 25S rRNA (adenine645-N1)-methyltransferase Saccharomyces cerevisiae Deletion of RRP8 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1144 850412 RRT12 Regulator of rDNA Transcription Saccharomyces cerevisiae YCR045C OSW3 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1321 853592 RSF2 ReSpiration Factor Saccharomyces cerevisiae YJR127C ZMS1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1273 856776 RSM18 Ribosomal Small subunit of Mitochondria Saccharomyces cerevisiae YER050C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1145 851755 RSM24 Ribosomal Small subunit of Mitochondria Saccharomyces cerevisiae YDR175C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1274 852444 RTC2 Restriction of Telomere Capping Saccharomyces cerevisiae YBR147W RRT11 YPQ3 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1146 855918 RTC6 Restriction of Telomere Capping Saccharomyces cerevisiae YPL183W-A TAE4 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1322 854087 RTG1 ReTroGrade regulation Saccharomyces cerevisiae YOL067C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1147 852640 RTG2 ReTroGrade regulation Saccharomyces cerevisiae YGL252C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1147 852640 RTG2 ReTroGrade regulation Saccharomyces cerevisiae YGL252C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 580 852171 RTG3 Rtg3p Saccharomyces cerevisiae YBL103C increase Knockout mutation causes an increase in lifespan. anti Knockout 2350: Jiang et al. (2000) "An intervention resembling caloric restriction prolongs life span and retards aging in yeast." FASEB J. 14(14):2135-2137 (11024000) 1148 851819 RTN1 ReTiculoN-like Saccharomyces cerevisiae YDR233C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1148 851819 RTN1 ReTiculoN-like Saccharomyces cerevisiae YDR233C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1149 855919 RTT10 Regulator of Ty1 Transposition Saccharomyces cerevisiae YPL183C ERE2 TRM734 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1429 856559 RTT107 Regulator of Ty1 Transposition Saccharomyces cerevisiae YHR154W ESC4 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1682 850367 RVS161 Reduced Viability on Starvation Saccharomyces cerevisiae YCR009C END6 FUS7 SPE161 decrease Deletion decreased replicative lifespan of the alpha-strain by 60% fitness 60 Deletion 2527: Liu et al. (2010) "The polarisome is required for segregation and retrograde transport of protein aggregates." Cell 140(2):257-267 (20141839) 1682 850367 RVS161 Reduced Viability on Starvation Saccharomyces cerevisiae YCR009C END6 FUS7 SPE161 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1682 850367 RVS161 Reduced Viability on Starvation Saccharomyces cerevisiae YCR009C END6 FUS7 SPE161 decrease Replicative lifespan decreased by 60% in a strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1596 852392 RXT2 Rxt2p Saccharomyces cerevisiae YBR095C RAF60 decrease Slightly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1501 853668 SAC1 Suppressor of ACtin Saccharomyces cerevisiae YKL212W RSD1 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1491 851707 SAC6 Suppressor of ACtin Saccharomyces cerevisiae YDR129C ABP67 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1275 853460 SAG1 Sexual AGglutination Saccharomyces cerevisiae YJR004C AG(ALPHA)1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1150 856866 SAK1 Snf1 Activating Kinase Saccharomyces cerevisiae YER129W PAK1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1659 855641 SAL1 Suppressor of Aac2 Lethality Saccharomyces cerevisiae YNL083W decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1660 850877 SAM1 S-AdenosylMethionine requiring Saccharomyces cerevisiae YLR180W ETH10 increase Replicative lifespan increased by 20% in the alpha strain and 15% in the a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1597 855305 SAP30 SIT4 protein phosphatase Associated Protein Saccharomyces cerevisiae YMR263W decrease Slightly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1620 852228 SAS3 Something About Silencing Saccharomyces cerevisiae YBL052C increase Survival increased during early chronological aging (day 5-15); anti Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1402 851762 SAS4 Something About Silencing Saccharomyces cerevisiae YDR181C increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 590 856612 SCH9 Protein kinase that regulates signal transduction activity and G1 progression Saccharomyces cerevisiae YHR205W HRM2 KOM1 increase Mutations increase resistance to oxidants and extend lifespan by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this life-extension. anti Mutations 2346: Fabrizio et al. (2001) "Regulation of longevity and stress resistance by Sch9 in yeast." Science 292(5515):288-290 (11292860) 590 856612 SCH9 Protein kinase that regulates signal transduction activity and G1 progression Saccharomyces cerevisiae YHR205W HRM2 KOM1 increase The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2). anti Deletion 338: Longo (2003) "The Ras and Sch9 pathways regulate stress resistance and longevity." Exp. Gerontol. 38(7):807-811 (12855292) 590 856612 SCH9 Protein kinase that regulates signal transduction activity and G1 progression Saccharomyces cerevisiae YHR205W HRM2 KOM1 increase Replicative lifespan increased by 40% in the alpha strain anti 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 590 856612 SCH9 Protein kinase that regulates signal transduction activity and G1 progression Saccharomyces cerevisiae YHR205W HRM2 KOM1 increase More than 3 fold extension of chronological lifespan, by day 9 of medium depletion all the WT yeast were dead while 50% sch9 mutants survived anti 300 Mutation 2267: Weinberger et al. (2007) "DNA replication stress is a determinant of chronological lifespan in budding yeast." PLoS ONE 2(8):e748 (17710147) 1151 855254 SCJ1 S. Cerevisiae DnaJ Saccharomyces cerevisiae YMR214W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 592 854549 SCP1 Scp1p Saccharomyces cerevisiae YOR367W increase Deletion increased lifespan by over 65%. anti 65 Deletion 2353: Gourlay et al. (2004) "A role for the actin cytoskeleton in cell death and aging in yeast." J. Cell Biol. 164(6):803-809 (15024029) 1276 853365 SCP160 S. cerevisiae protein involved in the Control of Ploidy Saccharomyces cerevisiae YJL080C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1276 853365 SCP160 S. cerevisiae protein involved in the Control of Ploidy Saccharomyces cerevisiae YJL080C decrease Replicative lifespan decreased by 10% in the alpha strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1276 853365 SCP160 S. cerevisiae protein involved in the Control of Ploidy Saccharomyces cerevisiae YJL080C increase Replicative lifespan increase by 30% in the a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 2135 853709 SDH1 succinate dehydrogenase flavoprotein subunit SDH1 Saccharomyces cerevisiae increase Deletion of SDH1 in yeast increased mean replicative lifespan. anti 25 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 2136 850685 SDH2 succinate dehydrogenase iron-sulfur protein subunit SDH2 Saccharomyces cerevisiae increase Deletion of SDH2 in yeast increased mean replicative lifespan. anti 21 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 2134 854083 SDH5 succinate dehydrogenase assembly factor SDH5 Saccharomyces cerevisiae increase Deletion of SDH5 in yeast increased mean replicative lifespan. anti 28 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1560 854693 SDP1 Stress-inducible Dual specificity Phosphatase Saccharomyces cerevisiae YIL113W increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1403 852824 SDS23 homolog of S. pombe SDS23 Saccharomyces cerevisiae YGL056C increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1598 854725 SDS3 Suppressor of Defective Silencing Saccharomyces cerevisiae YIL084C decrease Slightly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1447 854734 SEC28 SECretory Saccharomyces cerevisiae YIL076W ANU2 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1277 852469 SEC66 SECretory Saccharomyces cerevisiae YBR171W HSS1 SEC71 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1458 853756 SEG2 Stability of Eisosomes Guaranteed Saccharomyces cerevisiae YKL105C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1917 856519 SET1 histone methyltransferase SET1 Saccharomyces cerevisiae KMT2 YTX1 decrease Deletion of histone methyltransferase SET1 results in an decreased replicative lifespan. fitness 29 Deletion 3524: Ryu et al. (2014) "Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells." Biochem. Biophys. Res. Commun. 446(1):113-118 (24607280) 1585 853271 SET2 SET domain-containing Saccharomyces cerevisiae YJL168C EZL1 decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1585 853271 SET2 SET domain-containing Saccharomyces cerevisiae YJL168C EZL1 increase Deletion of histone methyltransferase SET2 results in an increased replicative lifespan. anti 40 Deletion 3524: Ryu et al. (2014) "Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells." Biochem. Biophys. Res. Commun. 446(1):113-118 (24607280) 1152 853900 SET3 SET domain-containing Saccharomyces cerevisiae YKR029C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1516 854307 SFL1 Suppressor gene for FLocculation Saccharomyces cerevisiae YOR140W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2143 856060 SGF11 SAGA histone acetyltransferase complex subunit SGF11 Saccharomyces cerevisiae increase Deletion of SGF11 in yeast increased mean replicative lifespan. anti 26 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1153 850347 SGF29 SaGa associated Factor Saccharomyces cerevisiae YCL010C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1153 850347 SGF29 SaGa associated Factor Saccharomyces cerevisiae YCL010C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1621 852814 SGF73 SaGa associated Factor, 73 kDa Saccharomyces cerevisiae YGL066W SCA7 decrease Strongly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 600 855228 SGS1 Sgs1p Saccharomyces cerevisiae YMR190C decrease Mutations cause premature ageing in mother cells including a shortened lifespan, sterility, and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. fitness Mutations 2356: Sinclair et al. (1997) "Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants." Science 277(5330):1313-1316 (9271578) 600 855228 SGS1 Sgs1p Saccharomyces cerevisiae YMR190C decrease To investigate the role of the RecQ helicase domain in ageing, a point mutation (SGS1 K(706)-->A) known to eliminate the DNA helicase activity of Sgs1p was constructed. This mutant allele failed to rescue the premature ageing of the sgs1Delta strain, demonstrating that Sgs1p DNA helicase activity is required for a normal lifespan pro Mutation 2534: Mankouri and Morgan (2001) "The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors." Mech. Ageing Dev. 122(11):1107-1120 (11389927) 600 855228 SGS1 Sgs1p Saccharomyces cerevisiae YMR190C decrease Replicative lifespan decreased by 30% pro 30 Deletion 2305: McVey et al. (2001) "The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination." Genetics 157(4):1531-1542 (11290710) 600 855228 SGS1 Sgs1p Saccharomyces cerevisiae YMR190C decrease A shortened life span pro Mutation 2305: McVey et al. (2001) "The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination." Genetics 157(4):1531-1542 (11290710) 1376 854168 SGT2 Small Glutamine-rich Tetratricopeptide repeat-containing protein Saccharomyces cerevisiae YOR007C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1492 852561 SHG1 Set1c, Hypothetical G Saccharomyces cerevisiae YBR258C CPS15 decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1404 852565 SHM1 Serine HydroxyMethyltransferase Saccharomyces cerevisiae YBR263W SHMT1 TMP3 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1404 852565 SHM1 Serine HydroxyMethyltransferase Saccharomyces cerevisiae YBR263W SHMT1 TMP3 decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1154 850747 SHM2 Serine HydroxyMethyltransferase Saccharomyces cerevisiae YLR058C SHMT2 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1154 850747 SHM2 Serine HydroxyMethyltransferase Saccharomyces cerevisiae YLR058C SHMT2 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1278 853009 SHY1 SURF Homolog of Yeast Saccharomyces cerevisiae YGR112W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1323 850768 SIC1 Substrate/Subunit Inhibitor of Cyclin-dependent protein kinase Saccharomyces cerevisiae YLR079W SDB25 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1324 852399 SIF2 Sir4p-Interacting Factor Saccharomyces cerevisiae YBR103W EMB1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1405 852032 SIP1 SNF1-Interacting Protein Saccharomyces cerevisiae YDR422C increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1405 852032 SIP1 SNF1-Interacting Protein Saccharomyces cerevisiae YDR422C decrease Replicative lifespan decreased by 80% pro 80 Deletion 2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (10921902) 1430 855213 SIP18 Salt Induced Protein Saccharomyces cerevisiae YMR175W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 603 852664 SIP2 Sip2p Saccharomyces cerevisiae YGL208W SPM2 decrease Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA. pro Deletion 2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (10921902) 603 852664 SIP2 Sip2p Saccharomyces cerevisiae YGL208W SPM2 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 603 852664 SIP2 Sip2p Saccharomyces cerevisiae YGL208W SPM2 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 603 852664 SIP2 Sip2p Saccharomyces cerevisiae YGL208W SPM2 decrease The esa1-531 strain showed a shortened replicative lifespan when grown at a semi-permissive temperature, 30C. Importantly, in an esa1-531 strain, the lysine-to-glutamine mutants of SIP2 (sip2-3KQ and sip2-4KQ), mimicking acetylated Sip2, reversed the shortened lifespan of esa1-531. pro 60 Acetylation mutants 3285: Lu et al. (2011) "Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction." Cell 146(6):969-979 (21906795) 1155 855464 SIP3 SNF1-Interacting Protein Saccharomyces cerevisiae YNL257C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1155 855464 SIP3 SNF1-Interacting Protein Saccharomyces cerevisiae YNL257C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 606 851520 SIR2 Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) Saccharomyces cerevisiae YDL042C MAR1 increase Overexpression extended lifespan by about 30%. pro 30 Overexpression 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 606 851520 SIR2 Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) Saccharomyces cerevisiae YDL042C MAR1 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 606 851520 SIR2 Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) Saccharomyces cerevisiae YDL042C MAR1 increase Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological LS extension (6 fold). anti 600 Deletion 1564: Fabrizio et al. (2005) "Sir2 blocks extreme life-span extension." Cell 123(4):655-667 (16286010) 607 851163 SIR3 Silent information regulator Saccharomyces cerevisiae YLR442C CMT1 MAR2 STE8 decrease Mutants show a 20% decrease in mean lifespan. fitness 20 Mutation 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 607 851163 SIR3 Silent information regulator Saccharomyces cerevisiae YLR442C CMT1 MAR2 STE8 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 608 851813 SIR4 Silent information regulator Saccharomyces cerevisiae YDR227W ASD1 STE9 UTH2 increase Mutation extends lifespan by more than 30%. anti 30 Mutation 2358: Kennedy et al. (1995) "Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae." Cell 80(3):485-496 (7859289) 608 851813 SIR4 Silent information regulator Saccharomyces cerevisiae YDR227W ASD1 STE9 UTH2 decrease The short life span of a sir4 mutant (20% decrease in mean life span) is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles. anti Mutation 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 608 851813 SIR4 Silent information regulator Saccharomyces cerevisiae YDR227W ASD1 STE9 UTH2 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1713 853946 SIS2 SIt4 Suppressor Saccharomyces cerevisiae YKR072C HAL3 increase Replicative lifespan increased by 50% in the alpha strain and 30% in the a strain anti 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1377 852018 SIZ1 SAP and mIZ-finger domain Saccharomyces cerevisiae YDR409W ULL1 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1608 854036 SKM1 STE20/PAK homologous Kinase related to Morphogenesis Saccharomyces cerevisiae YOL113W decrease Replicative lifespan decreased by 25% in the a strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1671 853045 SKN1 Suppressor of Kre Null Saccharomyces cerevisiae YGR143W increase Chronological lifespan increased by 60% for single skn1 and double ipt1-skn1 deletion anti 60 Deletion 2519: Aerts et al. (2006) "Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast." FEBS Lett. 580(7):1903-1907 (16527275) 1156 856613 SKN7 Suppressor of Kre Null Saccharomyces cerevisiae YHR206W BRY1 POS9 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1325 855554 SKO1 Suppressor of Kinase Overexpression Saccharomyces cerevisiae YNL167C ACR1 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1546 852276 SLA1 Synthetic Lethal with ABP1 Saccharomyces cerevisiae YBL007C decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1714 856852 SLX8 Synthetic Lethal of unknown (X) function Saccharomyces cerevisiae YER116C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1714 856852 SLX8 Synthetic Lethal of unknown (X) function Saccharomyces cerevisiae YER116C decrease Replicative lifespan decreased by 40% in the a strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1157 853144 SMI1 Suppressor of MAR Inhibitor Saccharomyces cerevisiae YGR229C KNR4 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1860 853290 SNA3 Sna3p Saccharomyces cerevisiae increase Deletion of sna3 extends chronological mean and maximum lifespan. anti 42 27 Deletion 3491: Borklu Yucel and Ulgen (2011) "A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae." PLoS ONE 6(12):e29284 (22216232) 619 852088 SNF1 AMP-activated serine/threonine protein kinase Saccharomyces cerevisiae YDR477W CAT1 CCR1 GLC2 HAF3 PAS14 decrease Overexpression shortened lifespan accompanied by signs of premature ageing. anti Overexpression 2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (10921902) 619 852088 SNF1 AMP-activated serine/threonine protein kinase Saccharomyces cerevisiae YDR477W CAT1 CCR1 GLC2 HAF3 PAS14 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 619 852088 SNF1 AMP-activated serine/threonine protein kinase Saccharomyces cerevisiae YDR477W CAT1 CCR1 GLC2 HAF3 PAS14 increase Replicative lifespan increased by 50% in the alpha strain anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 619 852088 SNF1 AMP-activated serine/threonine protein kinase Saccharomyces cerevisiae YDR477W CAT1 CCR1 GLC2 HAF3 PAS14 decrease Reduced chronological lifespan anti Overexpression 2538: Lorenz et al. (2009) "A network biology approach to aging in yeast." Proc. Natl. Acad. Sci. U.S.A. 106(4):1145-1150 (19164565) 1406 851333 SNF3 Sucrose NonFermenting Saccharomyces cerevisiae YDL194W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 620 852763 SNF4 Protein kinase activator found in a complex containing Snf1p and members of the Sip1p/Sip2p/Gal83p f Saccharomyces cerevisiae YGL115W CAT3 SCI1 increase Deleting SNF4 extends lifespan by 10-20%. anti 20 Deletion 2357: Ashrafi et al. (2000) "Sip2p and its partner snf1p kinase affect aging in S. cerevisiae." Genes Dev. 14(15):1872-1885 (10921902) 1407 854539 SNX3 Sorting NeXin Saccharomyces cerevisiae YOR357C GRD19 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1408 852035 SNX41 Sorting NeXin Saccharomyces cerevisiae YDR425W increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 621 853568 SOD1 Cu, Zn superoxide dismutase Saccharomyces cerevisiae YJR104C CRS4 increase Overexpression of Sod1 and Sod2 extends survival by 30%. pro 30 Overexpression 2271: Fabrizio et al. (2003) "SOD2 functions downstream of Sch9 to extend longevity in yeast." Genetics 163(1):35-46 (12586694) 621 853568 SOD1 Cu, Zn superoxide dismutase Saccharomyces cerevisiae YJR104C CRS4 increase Increasing the level of active Cu, Zn-Sod in yeast was found to require either growth in the presence of high copper, or the simultaneous overexpression of both SOD1 and CCS1 (the latter being the gene that encodes the chaperone dedicated to Cu(2+)-loading of Sod1p in vivo). Dual SOD1 + CCS1 overexpression elevated the levels of Cu,Zn-Sod activity six- to eight-fold in vegetative cultures. It also increased the optimized survival of stationary cells up to two-fold, showing this chronological lifespan is ultimately limited by oxidative stress. In contrast, several detrimental effects resulted when the SOD1 gene was overexpressed in the absence of either high copper or a simultaneous overexpression of CCS1. Both the chronological and the replicative lifespans were shortened; the cells displayed an abnormally high level of endogenous oxidative stress, resulting in a high rate of spontaneous mutation. Such harmful effects were all reversed through the overexpression of CCS1. pro Overexpression 2532: Harris et al. (2005) "Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase." Aging Cell 4(1):41-52 (15659212) 621 853568 SOD1 Cu, Zn superoxide dismutase Saccharomyces cerevisiae YJR104C CRS4 decrease 40% decrease in replicative lifespan fitness 40 Deletion 2257: Unlu and Koc (2007) "Effects of deleting mitochondrial antioxidant genes on life span." Ann. N. Y. Acad. Sci. 1100:505-509 (17460215) 623 856399 SOD2 Manganese-containing superoxide dismutase Saccharomyces cerevisiae YHR008C increase Overexpression of Sod1 and Sod2 extends survival by 30%. pro 30 Overexpression 2271: Fabrizio et al. (2003) "SOD2 functions downstream of Sch9 to extend longevity in yeast." Genetics 163(1):35-46 (12586694) 623 856399 SOD2 Manganese-containing superoxide dismutase Saccharomyces cerevisiae YHR008C decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 623 856399 SOD2 Manganese-containing superoxide dismutase Saccharomyces cerevisiae YHR008C decrease 72% replicative lifespan decrease fitness 72 Deletion 2257: Unlu and Koc (2007) "Effects of deleting mitochondrial antioxidant genes on life span." Ann. N. Y. Acad. Sci. 1100:505-509 (17460215) 1689 851569 SOK1 Suppressor Of Kinase Saccharomyces cerevisiae YDR006C increase Replicative lifespan increased by 50%-20% in the alpha and a strains anti 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1158 850437 SOL2 Suppressor Of Los1-1 Saccharomyces cerevisiae YCR073W-A YCRX13W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1834 855088 SOV1 Sov1p Saccharomyces cerevisiae increase A SOV1 deletion extends life span without affecting steady-state levels of ROS or oxidative damage. anti 50 30 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1627 851250 SPC72 Spindle Pole Component Saccharomyces cerevisiae YAL047C LDB4 decrease Replicative lifespan decreased by 80% in the alpha strain fitness 80 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1378 854105 SPE2 SPErmidine auxotroph Saccharomyces cerevisiae YOL052C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1349 854737 SPO22 SPOrulation Saccharomyces cerevisiae YIL073C ZIP4 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1894 855965 SPP1 Spp1p Saccharomyces cerevisiae CPS40 SAF41 Deletion of SPP1 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1690 852135 SPS1 SPorulation Specific Saccharomyces cerevisiae YDR523C increase Replicative lifespan increased by 25%-10% in the alpha and a strains anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1715 855518 SPS19 SPorulation Specific transcript Saccharomyces cerevisiae YNL202W SPX19 decrease Replicative lifespan decreased by 30% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1599 853315 SPT10 SuPpressor of Ty Saccharomyces cerevisiae YJL127C CRE1 SUD1 decrease Slightly reduced chronological lifespan fitness Deletion 2508: Eisenberg et al. (2009) "Induction of autophagy by spermidine promotes longevity." Nat. Cell Biol. 11(11):1305-1314 (19801973) 1716 852955 SPT4 SuPpressor of Ty's Saccharomyces cerevisiae YGR063C increase Replicative lifespan increased by 40% in alpha and a strains anti 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1279 850744 SPT8 SuPpressor of Ty Saccharomyces cerevisiae YLR055C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1280 852168 SRO77 Suppressor of rho3 Saccharomyces cerevisiae YBL106C SNI2 SOP2 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 339 853353 SRS2 Srs2p Saccharomyces cerevisiae YJL092W HPR5 decrease Mutants have a shortened lifespan. Replicative lifespan decreased by 30%. pro 30 Deletion 2305: McVey et al. (2001) "The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination." Genetics 157(4):1531-1542 (11290710) 1538 852203 SSA3 Stress-Seventy subfamily A Saccharomyces cerevisiae YBL075C YG106 increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1159 856840 SSA4 Stress-Seventy subfamily A Saccharomyces cerevisiae YER103W YG107 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1159 856840 SSA4 Stress-Seventy subfamily A Saccharomyces cerevisiae YER103W YG107 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 2110 853503 SSC1 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae increase Loss of the chaperone SSC1 in yeast triggers the activation of a cross-organelle stress response (CORE). Mean replicative lifespan after SSC1 deletion increased by 40%. Chronological lifespan also increased by 15%. anti 40 Deletion 4411: Perić et al. (2016) "Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan." Sci Rep 6:28751 (27346163) 632 851887 SSD1 Ssd1p Saccharomyces cerevisiae YDR293C CLA1 MCS1 RLT1 SRK1 increase Overexpression increased lifespan longevity by 50%, independently of Sir2, although Sir2 further extends lifespan. pro 50 Overexpression 2365: Kaeberlein et al. (2004) "Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism." Genetics 166(4):1661-1672 (15126388) 632 851887 SSD1 Ssd1p Saccharomyces cerevisiae YDR293C CLA1 MCS1 RLT1 SRK1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 632 851887 SSD1 Ssd1p Saccharomyces cerevisiae YDR293C CLA1 MCS1 RLT1 SRK1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 632 851887 SSD1 Ssd1p Saccharomyces cerevisiae YDR293C CLA1 MCS1 RLT1 SRK1 increase Replicative lifespan increase by 50% anti 50 Deletion 2537: Li et al. (2009) "Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells." Mol. Biol. Cell 20(17):3851-3864 (19570907) 1379 856463 SSF1 Suppressor of ste4 (Four) Saccharomyces cerevisiae YHR066W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1379 856463 SSF1 Suppressor of ste4 (Four) Saccharomyces cerevisiae YHR066W increase Replicative lifespan increased by 60% in the alpha strain anti 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1160 850692 SSK1 Suppressor of Sensor Kinase Saccharomyces cerevisiae YLR006C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1161 855765 SSK2 Suppressor of Sensor Kinase Saccharomyces cerevisiae YNR031C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1380 856065 SSN3 Suppressor of SNf1 Saccharomyces cerevisiae YPL042C CDK8 GIG2 NUT7 RYE5 SRB10 UME5 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1380 856065 SSN3 Suppressor of SNf1 Saccharomyces cerevisiae YPL042C CDK8 GIG2 NUT7 RYE5 SRB10 UME5 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1381 855844 SSO1 Sso1p Saccharomyces cerevisiae YPL232W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1281 855221 SSO2 Sso2p Saccharomyces cerevisiae YMR183C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1162 850952 SSP120 Ssp120p Saccharomyces cerevisiae YLR250W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1609 851076 STE11 STErile Saccharomyces cerevisiae YLR362W decrease Replicative lifespan decreased by 25% in the a strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1888 851426 STF1 Stf1p Saccharomyces cerevisiae AIS2 decrease Deletion of STF1 decreases yeast chronological lifespan. fitness Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1326 856050 SUR1 SUppressor of Rvs161 and rvs167 mutations Saccharomyces cerevisiae YPL057C BCL21 CSG1 LPE15 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1836 856078 SUV3 Suv3p Saccharomyces cerevisiae LPB2 increase The life span of cbs1D, cbp6D, suv3D, dss1D, pet122D, pet309D, and aep1D mutants was examined to check if the absence of members of the MTC module other than Sov1p leads to life span extension. Indeed, all those mutants were long-lived. anti 45 25 Mutation 3272: Caballero et al. (2011) "Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing." Mol. Cell 42(3):390-400 (21549315) 1350 851222 SWC3 SWr Complex Saccharomyces cerevisiae YAL011W SWC1 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1350 851222 SWC3 SWr Complex Saccharomyces cerevisiae YAL011W SWC1 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1475 852532 SWC5 SWr Complex Saccharomyces cerevisiae YBR231C AOR1 decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1418 851265 SWD1 Set1c, WD40 repeat protein Saccharomyces cerevisiae YAR003W CPS50 FUN16 SAF49 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1586 852472 SWD3 Set1c, WD40 repeat protein Saccharomyces cerevisiae YBR175W CPS30 SAF35 decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1282 853252 SWE1 Saccharomyces WEe1 Saccharomyces cerevisiae YJL187C WEE1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1431 851704 SWF1 Spore Wall Formation Saccharomyces cerevisiae YDR126W PSL10 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1431 851704 SWF1 Spore Wall Formation Saccharomyces cerevisiae YDR126W PSL10 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1448 851724 SWI5 SWItching deficient Saccharomyces cerevisiae YDR146C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1327 850879 SWI6 SWItching deficient Saccharomyces cerevisiae YLR182W PSL8 SDS11 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1163 855643 SWS2 Sick Without Securin Saccharomyces cerevisiae YNL081C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1164 852004 SXM1 Suppressor of mRNA eXport Mutant Saccharomyces cerevisiae YDR395W KAP108 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1328 854351 SYC1 Similar to Ysh1 C-terminal Saccharomyces cerevisiae YOR179C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1419 855999 SYH1 SmY2 Homolog Saccharomyces cerevisiae YPL105C MYR1 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1382 850953 SYM1 Stress-inducible Yeast Mpv17 Saccharomyces cerevisiae YLR251W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1165 853453 SYS1 Sys1p Saccharomyces cerevisiae YJL004C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1165 853453 SYS1 Sys1p Saccharomyces cerevisiae YJL004C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1636 856098 TAE2 Translation Associated Element Saccharomyces cerevisiae YPL009C decrease Replicative lifespan decreased by 30% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1691 855974 TAF14 TATA binding protein-Associated Factor Saccharomyces cerevisiae YPL129W ANC1 SWP29 TAF30 TFG3 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1691 855974 TAF14 TATA binding protein-Associated Factor Saccharomyces cerevisiae YPL129W ANC1 SWP29 TAF30 TFG3 decrease Replicative lifespan decreased by 50% in a strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1449 851068 TAL1 TransALdolase Saccharomyces cerevisiae YLR354C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1283 852619 TAN1 Trna AcetylatioN Saccharomyces cerevisiae YGL232W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1935 854139 TAT2 aromatic amino acid transmembrane transporter TAT2 Saccharomyces cerevisiae LTG3 SAB2 SCM2 TAP2 increase Deletion of TAT2 increases replicative lifespan. anti 23 Deletion 3537: He et al. (2014) "Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import." PLoS Genet. 10(12):e1004860 (25521617) 1859 854903 TCB3 Tcb3p Saccharomyces cerevisiae increase Deletion of tcb3 extends chronological mean and maximum lifespan. anti 25 18 Deletion 3491: Borklu Yucel and Ulgen (2011) "A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae." PLoS ONE 6(12):e29284 (22216232) 1329 852332 TCM62 TriCarboxylic acid cycle Mutant Saccharomyces cerevisiae YBR044C decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1434 851146 TDA5 Topoisomerase I Damage Affected Saccharomyces cerevisiae YLR426W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 2078 853465 TDH2 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Saccharomyces cerevisiae GLD2 increase Mutant cells lacking TDH2 display a longer replicative lifespan. anti 29 Deletion 3483: Hachinohe et al. (2013) "A reduction in age-enhanced gluconeogenesis extends lifespan." PLoS ONE 8(1):e54011 (23342062) 1166 854772 TED1 Trafficking of Emp24p/Erv25p-dependent cargo Disrupted Saccharomyces cerevisiae YIL039W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1351 855361 TGL3 TriacylGlycerol Lipase Saccharomyces cerevisiae YMR313C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1284 850420 THR4 THReonine requiring Saccharomyces cerevisiae YCR053W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1383 853933 TIF1 Translation Initiation Factor Saccharomyces cerevisiae YJL138C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1383 853933 TIF1 Translation Initiation Factor Saccharomyces cerevisiae YJL138C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1383 853933 TIF1 Translation Initiation Factor Saccharomyces cerevisiae YJL138C increase Replicative lifespan increased by 30% in the alpha strain and 15% in the a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1167 853303 TIF2 Translation Initiation Factor Saccharomyces cerevisiae YJL138C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1167 853303 TIF2 Translation Initiation Factor Saccharomyces cerevisiae YJL138C decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1167 853303 TIF2 Translation Initiation Factor Saccharomyces cerevisiae YJL138C increase Replicative lifespan increased by 35% in the alpha strain and 15% in the a strain anti 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1645 853071 TIF4631 Translation Initiation Factor Saccharomyces cerevisiae YGR162W increase Replicative lifespan increased by 10%-20% in the alpha and a strains anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1645 853071 TIF4631 Translation Initiation Factor Saccharomyces cerevisiae YGR162W increase Replicative lifespan increased by 20% in the alpha and a strains anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1661 852833 TIF4632 Translation Initiation Factor Saccharomyces cerevisiae YGL049C increase Replicative lifespan increased by 20% in the a strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1717 850827 TIS11 similar to the mammalian TPA Induced Sequence gene family Saccharomyces cerevisiae YLR136C CTH2 increase Replicative lifespan increased by 30% in the alpha strain and increased by 25% in the a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 674 9164870 TLC1 telomerase_RNA Saccharomyces cerevisiae increase Overexpression extends lifespan approximately by 20%. pro 20 Overexpression 2371: Austriaco and Guarente (1997) "Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae." Proc. Natl. Acad. Sci. U.S.A. 94(18):9768-9772 (9275199) 674 9164870 TLC1 telomerase_RNA Saccharomyces cerevisiae decrease Decreased replicative lifespan pro Deletion 2529: Nugent et al. (1996) "Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance." Science 274(5285):249-252 (8824190) 1628 853809 TMA19 Translation Machinery Associated Saccharomyces cerevisiae YKL056C MMI1 increase Replicative lifespan increased by 15% anti 15 Deletion 2513: Rinnerthaler et al. (2006) "MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria." Biochim. Biophys. Acta 1757(5-6):631-638 (16806052) 1628 853809 TMA19 Translation Machinery Associated Saccharomyces cerevisiae YKL056C MMI1 increase Replicative lifespan increased by 30%-25% in the alpha and a strains anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1646 852068 TOM1 Temperature dependent Organization in Mitotic nucleus Saccharomyces cerevisiae YDR457W increase Replicative lifespan increased by 10%-20% in the alpha and a strains anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1646 852068 TOM1 Temperature dependent Organization in Mitotic nucleus Saccharomyces cerevisiae YDR457W increase Tom1 mutants exhibit increased replicative lifespan. anti 30 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1168 856517 TOM71 Translocase of the Outer Mitochondrial membrane Saccharomyces cerevisiae YHR117W TOM72 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1547 854156 TOP1 TOPoisomerase Saccharomyces cerevisiae YOL006C MAK1 MAK17 decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 679 853529 TOR1 PIK-related protein kinase and rapamycin target Saccharomyces cerevisiae YJR066W DRR1 increase Deletion increased mean and maximum lifespan by 20%. anti 20 20 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 679 853529 TOR1 PIK-related protein kinase and rapamycin target Saccharomyces cerevisiae YJR066W DRR1 increase Deletion of TOR1 substantially extended chronological life span, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days). By 21 days in culture, the vast majorityof wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extended the chronological life span of the relatively short-lived strain BY4742, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extendLS in Petite strains that are unable to respire anti Deletion 1849: Bonawitz et al. (2007) "Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression." Cell Metab. 5(4):265-277 (17403371) 679 853529 TOR1 PIK-related protein kinase and rapamycin target Saccharomyces cerevisiae YJR066W DRR1 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 679 853529 TOR1 PIK-related protein kinase and rapamycin target Saccharomyces cerevisiae YJR066W DRR1 increase Replicative lifespan increased by 30% in the alpha strain and 20% in a strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1718 852696 TOS3 Target Of Sbf Saccharomyces cerevisiae YGL179C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1718 852696 TOS3 Target Of Sbf Saccharomyces cerevisiae YGL179C decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1285 852783 TOS8 Target Of Sbf Saccharomyces cerevisiae YGL096W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1285 852783 TOS8 Target Of Sbf Saccharomyces cerevisiae YGL096W increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1392 852988 TPC1 Thiamine Pyrophosphate Carrier Saccharomyces cerevisiae YGR096W decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1502 853275 TPK1 Takashi's Protein Kinase Saccharomyces cerevisiae YJL164C PKA1 SRA3 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 681 855898 TPK2 Tpk2p Saccharomyces cerevisiae YPL203W PKA2 PKA3 YKR1 increase Deletion of TPK2 in a tpk1 and tpk3 double mutant background extends lifespan by approximately 25%. anti 25 Deletion 2260: Lin et al. (2000) "Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae." Science 289(5487):2126-2128 (11000115) 1632 853688 TPK3 Takashi's Protein Kinase Saccharomyces cerevisiae YKL166C decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1610 855645 TPM1 TroPoMyosin Saccharomyces cerevisiae YNL079C decrease Replicative lifespan decreased by 40% in the a strain fitness 40 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1676 850631 TPO1 Transporter of POlyamines Saccharomyces cerevisiae YLL028W decrease Deletion caused mean replicative lifespan decrease by 8.2% in the alpha strain and by 31.5% in the a strain fitness 32 Deletion 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 1676 850631 TPO1 Transporter of POlyamines Saccharomyces cerevisiae YLL028W increase Overexpression caused replicative lifespan increase by 24.4% in the alpha strain and by 21.4% in the a strain pro 25 Overexpression 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 1169 856077 TRM44 TRna Methyltransferase Saccharomyces cerevisiae YPL030W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1517 854994 TRM9 TRna Methyltransferase Saccharomyces cerevisiae YML014W KTI1 increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1065 851686 TRS85 TRapp Subunit Saccharomyces cerevisiae YDR108W GSG1 MUM1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1065 851686 TRS85 TRapp Subunit Saccharomyces cerevisiae YDR108W GSG1 MUM1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1286 850732 TRX1 ThioRedoXin Saccharomyces cerevisiae YLR043C LMA1 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1286 850732 TRX1 ThioRedoXin Saccharomyces cerevisiae YLR043C LMA1 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 2109 854980 TSA1 thioredoxin peroxidase TSA1 Saccharomyces cerevisiae increase Overexpression of Tsa1 in yeast extended lifespan in a Hsp70 chaperone-dependent and CR-independent manner and also counteracted the typical progressive fitness decline of ageing mother cells. pro Overexpression 4410: Hanzén et al. (2016) "Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins." Cell 166(1):140-151 (27264606) 1476 851677 TVP15 Tlg2-Vesicle Protein Saccharomyces cerevisiae YDR100W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1477 851657 TVP23 Tlg2-Vesicle Protein Saccharomyces cerevisiae YDR084C decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1384 852971 TWF1 TWinFilin Saccharomyces cerevisiae YGR080W decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1352 854470 UAF30 Upstream Activation Factor subunit Saccharomyces cerevisiae YOR295W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1575 851015 UBC12 UBiquitin-Conjugating Saccharomyces cerevisiae YLR306W increase Mean chronological lifespan increased in the a strain by more than 50% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1287 856704 UBC8 UBiquitin-Conjugating Saccharomyces cerevisiae YEL012W GID3 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1287 856704 UBC8 UBiquitin-Conjugating Saccharomyces cerevisiae YEL012W GID3 decrease Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1170 850620 UBI4 Ubiquitin Saccharomyces cerevisiae YLL039C SCD2 UB14 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1889 852349 UBP14 Ubp14p Saccharomyces cerevisiae GID6 decrease Deletion of UBP14 decreases yeast chronological lifespan. fitness Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 2019 850562 UBP6 Ubp6p Saccharomyces cerevisiae decrease Ubp6 mutants exhibit reduced replicative lifespan. fitness 32 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1171 855263 UBP8 UBiquitin-specific processing Protease Saccharomyces cerevisiae YMR223W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 2021 850711 UBR2 putative ubiquitin-protein ligase UBR2 Saccharomyces cerevisiae increase Ubr2 mutants exhibit increased replicative lifespan. anti 67 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1866 854995 UBX2 Ubx2p Saccharomyces cerevisiae SEL1 increase Deletion of ubx2 (sel1), a target of the unfolded protein response signaling, decreases replicative lifespan. anti 24 Deletion 3493: Labunskyy et al. (2014) "Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response." PLoS Genet. 10(1):e1004019 (24391512) 1172 855089 UBX4 UBiquitin regulatory X Saccharomyces cerevisiae YMR067C CUI1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1173 851337 UFD2 Ubiquitin Fusion Degradation Saccharomyces cerevisiae YDL190C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1539 852902 UGA1 Utilization of GAba Saccharomyces cerevisiae YGR019W increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1735 851384 UGA3 Utilization of GAba Saccharomyces cerevisiae YDL170W increase Mean replicative lifespan increased by 75% in the alpha strain anti 75 Deletion 2531: Yoshida et al. (2010) "Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants." Aging Cell 9(4):616-625 (20550517) 1493 851788 UME6 Unscheduled Meiotic gene Expression Saccharomyces cerevisiae YDR207C CAR80 NIM2 RIM16 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 700 852471 UMP1 Ump1p Saccharomyces cerevisiae YBR173C RNS2 increase Overexpression caused an enhanced preservation of proteasome-mediated protein degradation and enhanced viability during stationary-phase ageing. pro Overexpression 2374: Chen et al. (2006) "Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome?" Free Radic. Biol. Med. 40(1):120-126 (16337885) 700 852471 UMP1 Ump1p Saccharomyces cerevisiae YBR173C RNS2 decrease Ump1 mutants exhibit reduced replicative lifespan. fitness 32 Deletion 3563: Kruegel et al. (2011) "Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae." PLoS Genet. 7(9):e1002253 (21931558) 1288 852963 UPF3 UP Frameshift Saccharomyces cerevisiae YGR072W SUA6 SUP112 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1174 850865 UPS2 UnProceSsed Saccharomyces cerevisiae YLR168C AIM30 GEP1 MSF1 MSF1' decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 713 855492 URE2 Ure2p Saccharomyces cerevisiae YNL229C increase Deletion increased mean replicative lifespan by 20%. anti 20 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 713 855492 URE2 Ure2p Saccharomyces cerevisiae YNL229C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1736 852009 URH1 URidine Hydrolase Saccharomyces cerevisiae YDR400W increase Mean replicative lifespan increased by 24% in the alpha strain anti 24 Deletion 2531: Yoshida et al. (2010) "Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants." Aging Cell 9(4):616-625 (20550517) 1409 855871 USV1 Up in StarVation Saccharomyces cerevisiae YPL230W NSF1 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 714 853916 UTH1 Uth1p Saccharomyces cerevisiae YKR042W increase Mutation increases lifespan by approximately 15% and increases stress resistance. anti 15 Mutation 2358: Kennedy et al. (1995) "Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae." Cell 80(3):485-496 (7859289) 1175 856713 VAB2 VAc8p Binding Saccharomyces cerevisiae YEL005C VAB31 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1176 850296 VAC17 VACuole related Saccharomyces cerevisiae YCL063W YCL062W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1289 856702 VAC8 VACuole related Saccharomyces cerevisiae YEL013W YEB3 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1289 856702 VAC8 VACuole related Saccharomyces cerevisiae YEL013W YEB3 decrease Replicative lifespan decreased fitness Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1290 854234 VAM10 VAcuolar Morphogenesis Saccharomyces cerevisiae YOR068C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1548 854273 VAM3 VAcuolar Morphogenesis Saccharomyces cerevisiae YOR106W PTH1 decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1548 854273 VAM3 VAcuolar Morphogenesis Saccharomyces cerevisiae YOR106W PTH1 decrease Replicative lifespan decreased by 60% fitness 60 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1667 852660 VAM7 VAcuolar Morphogenesis Saccharomyces cerevisiae YGL212W VPL24 VPS43 decrease Replicative lifespan decreased by 70% on CR medium fitness 70 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1567 853980 VBA5 Vacuolar Basic Amino acid transporter Saccharomyces cerevisiae YKR105C increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1177 851834 VHS1 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae YDR247W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1177 851834 VHS1 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae YDR247W increase Replicative lifespan increased anti Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 1177 851834 VHS1 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae YDR247W increase Replicative lifespan increased by 60% in the alpha strain anti 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1178 854220 VHS3 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae YOR054C YOR29-05 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1478 851088 VID22 Vacuolar Import and Degradation Saccharomyces cerevisiae YLR373C decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1179 852624 VID30 Vacuolar Import and Degradation Saccharomyces cerevisiae YGL227W GID1 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1179 852624 VID30 Vacuolar Import and Degradation Saccharomyces cerevisiae YGL227W GID1 increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1440 851342 VMA1 Vacuolar Membrane Atpase Saccharomyces cerevisiae YDL185W CLS8 TFP1 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1633 852424 VMA2 Vacuolar Membrane Atpase Saccharomyces cerevisiae YBR127C VAT2 decrease Replicative lifespan decreased by 80% in the alpha strain fitness 80 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1549 852997 VMA21 Vma21p Saccharomyces cerevisiae YGR105W decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1550 851168 VMA6 Vma6p Saccharomyces cerevisiae YLR447C decrease Replicative lifespan decreased by 60% in the alpha strain fitness 60 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1295 851618 VMS1 VCP/Cdc48-associated Mitochondrial Stress-responsive Saccharomyces cerevisiae YDR049W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1295 851618 VMS1 VCP/Cdc48-associated Mitochondrial Stress-responsive Saccharomyces cerevisiae YDR049W decrease Replicative lifespan decreased by 25% in the alpha strain fitness 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1719 854444 VPH1 Vacuolar pH Saccharomyces cerevisiae YOR270C increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1719 854444 VPH1 Vacuolar pH Saccharomyces cerevisiae YOR270C decrease Replicative lifespan decreased by 15% in the a strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1745 855101 VPS20 Vacuolar Protein Sorting 20 Saccharomyces cerevisiae YMR077C CHM6 VPL10 VPT20 decrease VPS20 deletion decreases mean and maximum replicative lifespan under ad libitum, and cancels the dietary restriction-induced replicative lifespan extension. fitness 19 16 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1180 854256 VPS21 Vacuolar Protein Sorting Saccharomyces cerevisiae YOR089C VPS12 VPT12 YPT21 YPT51 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1330 853825 VPS24 Vacuolar Protein Sorting Saccharomyces cerevisiae YKL041W DID3 VPL26 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1181 853566 VPS25 Vacuolar Protein Sorting Saccharomyces cerevisiae YJR102C VPL12 VPT25 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1182 855739 VPS27 Vacuolar Protein Sorting Saccharomyces cerevisiae YNR006W DID7 GRD11 SSV17 VPL23 VPT27 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1291 855983 VPS30 Vacuolar Protein Sorting Saccharomyces cerevisiae YPL120W APG6 ATG6 VPT30 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1720 850941 VPS34 Vacuolar Protein Sorting Saccharomyces cerevisiae YLR240W END12 PEP15 STT8 VPL7 VPS7 VPT29 decrease Replicative lifespan decreased by 60% in the a strain fitness 60 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1292 851074 VPS38 Vacuolar Protein Sorting Saccharomyces cerevisiae YLR360W VPL17 decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1331 851653 VPS41 Vacuolar Protein Sorting Saccharomyces cerevisiae YDR080W CVT8 FET2 SVL2 VAM2 VPL20 decrease Mean chronological lifespan strongly decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1331 851653 VPS41 Vacuolar Protein Sorting Saccharomyces cerevisiae YDR080W CVT8 FET2 SVL2 VAM2 VPL20 decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1353 854235 VPS5 Vacuolar Protein Sorting Saccharomyces cerevisiae YOR069W GRD2 PEP10 VPT5 increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1293 853042 VPS62 Vacuolar Protein Sorting Saccharomyces cerevisiae YGR141W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1354 853590 VPS70 Vacuolar Protein Sorting Saccharomyces cerevisiae YJR126C increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1355 855475 VPS75 Vacuolar Protein Sorting Saccharomyces cerevisiae YNL246W increase Mean chronological lifespan strongly increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1183 851261 VPS8 Vacuolar Protein Sorting Saccharomyces cerevisiae YAL002W FUN15 VPL8 VPT8 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1483 851051 VRP1 VeRProlin Saccharomyces cerevisiae YLR337C END5 MDP2 YLR337W decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1184 850878 VTA1 VpsTwenty Associated Saccharomyces cerevisiae YLR181C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1494 854208 WHI2 WHIskey Saccharomyces cerevisiae YOR043W decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1185 855524 WHI3 WHIskey Saccharomyces cerevisiae YNL197C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1185 855524 WHI3 WHIskey Saccharomyces cerevisiae YNL197C decrease Replicative lifespan decreased by 25% in the a strain fitness 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1441 856357 WSC4 cell Wall integrity and Stress response Component Saccharomyces cerevisiae YHL028W YFW1 YHC8 decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1895 853300 YAK1 serine/threonine protein kinase YAK1 Saccharomyces cerevisiae Deletion of YAK1 does not affect chronological lifespan. Deletion 3506: Garay et al. (2014) "High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions." PLoS Genet. 10(2):e1004168 (24586198) 1186 852346 YBR056W 17-beta-hydroxysteroid dehydrogenase-like protein Saccharomyces cerevisiae YBR056W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1186 852346 YBR056W 17-beta-hydroxysteroid dehydrogenase-like protein Saccharomyces cerevisiae YBR056W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1495 852526 YBR225W hypothetical protein Saccharomyces cerevisiae YBR225W decrease Replicative lifespan decreased by 40% in the alpha strain fitness 40 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 774 852540 YBR238C hypothetical protein Saccharomyces cerevisiae YBR238C increase Deletion increased mean replicative lifespan by 30%. anti 30 Deletion 1570: Kaeberlein et al. (2005) "Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients." Science 310(5751):1193-1196 (16293764) 774 852540 YBR238C hypothetical protein Saccharomyces cerevisiae YBR238C increase Replicative lifespan increased by 30% in the alpha and a strains anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1294 852587 YBR284W metallo-dependent hydrolase superfamily protein Saccharomyces cerevisiae YBR284W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1187 850360 YCP4 Ycp4p Saccharomyces cerevisiae YCR004C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1187 850360 YCP4 Ycp4p Saccharomyces cerevisiae YCR004C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1188 850410 YCR043C hypothetical protein Saccharomyces cerevisiae YCR043C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1189 850417 YCR050C hypothetical protein Saccharomyces cerevisiae YCR050C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1470 856018 YDC1 Yeast DihydroCeramidase Saccharomyces cerevisiae YPL087W decrease Mean chronological lifespan decreased in the a strain by more than 50% fitness 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1470 856018 YDC1 Yeast DihydroCeramidase Saccharomyces cerevisiae YPL087W decrease Chronological lifespan decreased by 40% anti 40 Overexpression 2520: Aerts et al. (2008) "Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast." Cell. Mol. Life Sci. 65(12):1933-1942 (18500447) 1470 856018 YDC1 Yeast DihydroCeramidase Saccharomyces cerevisiae YPL087W increase Chronological lifespan increased anti Deletion 2520: Aerts et al. (2008) "Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast." Cell. Mol. Life Sci. 65(12):1933-1942 (18500447) 1190 851502 YDL057W hypothetical protein Saccharomyces cerevisiae YDL057W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1432 851663 YDR089W hypothetical protein Saccharomyces cerevisiae YDR089W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1692 851702 YDR124W hypothetical protein Saccharomyces cerevisiae YDR124W increase Replicative lifespan increased by 30% in the alpha anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1692 851702 YDR124W hypothetical protein Saccharomyces cerevisiae YDR124W decrease Replicative lifespan decrease by 10% in a strain fitness 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1581 851710 YDR132C hypothetical protein Saccharomyces cerevisiae YDR132C decrease Replicative lifespan decreased by 35% in the alpha strain fitness 35 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1450 851835 YDR248C gluconokinase Saccharomyces cerevisiae YDR248C increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1433 851855 YDR262W hypothetical protein Saccharomyces cerevisiae YDR262W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1522 856935 YER186C hypothetical protein Saccharomyces cerevisiae YER186C increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1523 856937 YER187W hypothetical protein Saccharomyces cerevisiae YER187W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1674 851437 YFH1 Yeast Frataxin Homolog Saccharomyces cerevisiae YDL120W decrease Replicative lifespan decreased by 50% pro 50 Deletion 2522: Desmyter et al. (2004) "Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death." Exp. Gerontol. 39(5):707-715 (15130665) 1191 852874 YGL010W hypothetical protein Saccharomyces cerevisiae YGL010W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1192 852615 YGL235W hypothetical protein Saccharomyces cerevisiae YGL235W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1192 852615 YGL235W hypothetical protein Saccharomyces cerevisiae YGL235W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1192 852615 YGL235W hypothetical protein Saccharomyces cerevisiae YGL235W increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1193 852944 YGR053C hypothetical protein Saccharomyces cerevisiae YGR053C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1721 853031 YGR130C hypothetical protein Saccharomyces cerevisiae YGR130C increase Replicative lifespan increased by 30% in the alpha strain and increased by 20% in the a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1721 853031 YGR130C hypothetical protein Saccharomyces cerevisiae YGR130C increase Deletion of ygr130c extends chronological mean and maximum lifespan. anti 50 18 Deletion 3491: Borklu Yucel and Ulgen (2011) "A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae." PLoS ONE 6(12):e29284 (22216232) 1296 853165 YGR250C hypothetical protein Saccharomyces cerevisiae YGR250C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1673 853387 YHC3 Yeast Homolog of human Cln3 Saccharomyces cerevisiae YJL059W BTN1 decrease 10-20% shortened lifespan fitness 20 Deletion 2521: de Voer et al. (2005) "Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype." J. Inherit. Metab. Dis. 28(6):1065-1080 (16435200) 1194 856381 YHL008C hypothetical protein Saccharomyces cerevisiae YHL008C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1634 854811 YIA6 Yia6p Saccharomyces cerevisiae YIL006W NDT1 decrease Replicative lifespan decreased by 30% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1297 850423 YIH1 Yeast Impact Homolog Saccharomyces cerevisiae YCR059C decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1195 854733 YIL077C hypothetical protein Saccharomyces cerevisiae YIL077C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1196 853294 YJL147C hypothetical protein Saccharomyces cerevisiae YJL147C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1298 853845 YKL023W hypothetical protein Saccharomyces cerevisiae YKL023W decrease Mean chronological lifespan decreased in the a strain fitness Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943) 1623 853794 YKL069W hypothetical protein Saccharomyces cerevisiae YKL069W YKG9 decrease Replicative lifespan decreased pro Deletion 2512: Le et al. (2009) "Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae." J. Biol. Chem. 284(7):4354-4364 (19049972) 776 855328 YKU70 Subunit of the telomeric Ku complex (Yku70p-Yku80p) Saccharomyces cerevisiae YMR284W HDF1 NES24 decrease Mutants had a shorter lifespan. fitness Mutation 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 776 855328 YKU70 Subunit of the telomeric Ku complex (Yku70p-Yku80p) Saccharomyces cerevisiae YMR284W HDF1 NES24 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 777 855132 YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p) Saccharomyces cerevisiae YMR106C HDF2 decrease Mutants had a shorter lifespan. fitness Mutation 200: Kaeberlein et al. (1999) "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms." Genes Dev. 13(19):2570-2580 (10521401) 1198 851021 YLR312C hypothetical protein Saccharomyces cerevisiae YLR312C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1552 851141 YLR422W hypothetical protein Saccharomyces cerevisiae YLR422W increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1435 851182 YLR460C hypothetical protein Saccharomyces cerevisiae YLR460C decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1635 856135 YME1 Yeast Mitochondrial Escape Saccharomyces cerevisiae YPR024W OSD1 YTA11 decrease Replicative lifespan decreased by 45% in the alpha strain fitness 45 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1635 856135 YME1 Yeast Mitochondrial Escape Saccharomyces cerevisiae YPR024W OSD1 YTA11 decrease Chronological lifespan decreased up to 50% fitness 50 Deletion 2516: Francis et al. (2007) "Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae." J. Bioenerg. Biomembr. 39(2):127-144 (17492370) 1527 855022 YMR010W hypothetical protein Saccharomyces cerevisiae YMR010W increase Replicative lifespan increased by 30% in the alpha strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1592 855032 YMR018W hypothetical protein Saccharomyces cerevisiae YMR018W increase Replicative lifespan increased by 35% in the alpha strain anti 35 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1199 855108 YMR084W hypothetical protein Saccharomyces cerevisiae YMR084W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1200 855125 YMR099C glucose-6-phosphate 1-epimerase Saccharomyces cerevisiae YMR099C decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1420 855202 YMR166C hypothetical protein Saccharomyces cerevisiae YMR166C decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1203 855531 YNL190W hypothetical protein Saccharomyces cerevisiae YNL190W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1480 855803 YNR066C hypothetical protein Saccharomyces cerevisiae YNR066C decrease Replicative lifespan decreased by 50% in the alpha strain fitness 50 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1519 854177 YOR012W hypothetical protein Saccharomyces cerevisiae YOR012W increase Mean replicative lifespan increased in the alpha and a strain anti Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1204 854217 YOR052C hypothetical protein Saccharomyces cerevisiae YOR052C YOR29-03 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1677 853198 YOR1 Yeast Oligomycin Resistance Saccharomyces cerevisiae YGR281W YRS1 decrease Deletion caused replicative lifespan decrease by 15.8% in the alpha strain and by 11.3% in the a strain fitness 16 Deletion 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 1677 853198 YOR1 Yeast Oligomycin Resistance Saccharomyces cerevisiae YGR281W YRS1 increase Overexpression caused replicative lifespan increased by 35.6% in the alpha strain and by 12.4% in the a strain pro 36 Overexpression 2523: Eldakak et al. (2010) "Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing." Nat. Cell Biol. 12(8):799-805 (20657593) 1647 851627 YOS9 Yeast OS-9 homolog Saccharomyces cerevisiae YDR057W decrease Replicative lifespan decreased by 10% in the alpha strain fitness 10 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1582 852481 YPC1 Yeast Phyto-Ceramidase Saccharomyces cerevisiae YBR183W decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1421 853733 YPK1 Yeast Protein Kinase Saccharomyces cerevisiae YKL126W SLI2 decrease Replicative lifespan decreased by 20% in the alpha strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1205 855953 YPL150W non-specific serine/threonine protein kinase Saccharomyces cerevisiae YPL150W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1206 855876 YPL225W hypothetical protein Saccharomyces cerevisiae YPL225W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1748 854061 YPQ1 Ypq1p Saccharomyces cerevisiae YOL092W decrease Deletion of YOL092W decreases mean and maximum replicative lifespan. Lifespan of YOL092Y deletion mutants can be extended by 0.5% glucose restriction. fitness 21 36 Deletion 2549: Wuttke et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genet. 8(8):e1002834 (22912585) 1662 856121 YPR011C hypothetical protein Saccharomyces cerevisiae YPR011C decrease Replicative lifespan decreased by 20% in the a strain fitness 20 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1207 856276 YPR153W hypothetical protein Saccharomyces cerevisiae YPR153W decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1693 850966 YPT6 Yeast Protein Two Saccharomyces cerevisiae YLR262C increase Replicative lifespan increased by 20% anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1693 850966 YPT6 Yeast Protein Two Saccharomyces cerevisiae YLR262C increase Replicative lifespan increased by 30% in the alpha strain and by 10% in the a strain anti 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1208 855012 YPT7 Yeast Protein Two Saccharomyces cerevisiae YML001W AST4 VAM4 decrease Mean replicative lifespan decreased in the alpha and a strain fitness Deletion 2500: Fabrizio et al. (2010) "Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation." PLoS Genet. 6(7):e1001024 (20657825) 1208 855012 YPT7 Yeast Protein Two Saccharomyces cerevisiae YML001W AST4 VAM4 decrease Replicative lifespan decreased by 15% in the alpha strain fitness 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1208 855012 YPT7 Yeast Protein Two Saccharomyces cerevisiae YML001W AST4 VAM4 decrease Replicative lifespan decreased by 40% on CR medium fitness 40 Deletion 2514: Tang et al. (2008) "A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery." Autophagy 4(7):874-886 (18690010) 1451 856409 YSC84 Ysc84p Saccharomyces cerevisiae YHR016C LSB4 increase Replicative lifespan increased by 20% in the alpha strain anti 20 Deletion 2503: Managbanag et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802 (19030232) 1451 856409 YSC84 Ysc84p Saccharomyces cerevisiae YHR016C LSB4 increase Replicative lifespan increased by 25% in the alpha strain anti 25 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1540 853186 YTA7 Yeast Tat-binding Analog Saccharomyces cerevisiae YGR270W increase Mean chronological lifespan increased in the a strain by less than 50% but more than 15% anti 50 Deletion 2502: Laschober et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097 (20883526) 1442 853562 YUH1 Yeast Ubiquitin Hydrolase Saccharomyces cerevisiae YJR099W decrease Replicative lifespan decreased by 30% in the alpha strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 2142 853302 YUR1 mannosyltransferase YUR1 Saccharomyces cerevisiae increase Deletion of YUR1 in yeast increased mean replicative lifespan. anti 19 Deletion 4414: McCormick et al. (2015) "A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging." Cell Metab. 22(5):895-906 (26456335) 1663 854844 YVH1 Yeast vaccinia virus VH1 Homolog Saccharomyces cerevisiae YIR026C increase Replicative lifespan increased by 50% in the alpha strain anti 50 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 781 855316 ZDS1 Zds1p Saccharomyces cerevisiae YMR273C CES1 CKM1 NRC1 OSS1 increase Deletion increases lifespan by 37% in a Sir3p-dependent manner. anti 37 Deletion 2378: Roy and Runge (2000) "Two paralogs involved in transcriptional silencing that antagonistically control yeast life span." Curr. Biol. 10(2):111-114 (10662670) 1696 854931 ZDS2 Zillion Different Screens Saccharomyces cerevisiae YML109W CES4 decrease Mean replicative lifespan decreased by 20% pro 20 Deletion 2378: Roy and Runge (2000) "Two paralogs involved in transcriptional silencing that antagonistically control yeast life span." Curr. Biol. 10(2):111-114 (10662670) 1637 851879 ZIP1 molecular ZIPper Saccharomyces cerevisiae YDR285W decrease Replicative lifespan decreased by 30% in the a strain fitness 30 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1722 852335 ZTA1 ZeTA-crystallin Saccharomyces cerevisiae YBR046C increase Replicative lifespan increased by 15% in the alpha strain anti 15 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1722 852335 ZTA1 ZeTA-crystallin Saccharomyces cerevisiae YBR046C decrease Replicative lifespan decreased by 10% in the a strain fitness 10 Deletion 2504: Smith et al. (2008) "Quantitative evidence for conserved longevity pathways between divergent eukaryotic species." Genome Res. 18(4):564-570 (18340043) 1412 855480 ZWF1 ZWischenFerment Saccharomyces cerevisiae YNL241C MET19 POS10 increase Mean chronological lifespan increased in the a strain anti Deletion 2501: Matecic et al. (2010) "A microarray-based genetic screen for yeast chronological aging factors." PLoS Genet. 6(4):e1000921 (20421943)