Ageing-Associated Genes in Model Organisms

Found 136 results. Showing results 1 to 136.

Entrez ID Symbol Name Organism Longevity influence Max average lifespan change More details
224129 Adcy5 adenylate cyclase 5 Mus musculus Anti-Longevity 30% Increase Adcy5
11549 Adra1a adrenergic receptor, alpha 1a Mus musculus Pro-Longevity 10% Increase Adra1a
11548 Adra1b adrenergic receptor, alpha 1b Mus musculus Anti-Longevity 11% Decrease Adra1b
11607 Agtr1a Angiotensin II receptor, type 1a Mus musculus Anti-Longevity 26% Increase Agtr1a
11651 Akt1 thymoma viral proto-oncogene 1 Mus musculus Anti-Longevity 12% Increase Akt1
11816 Apoe Apolipoprotein E Mus musculus Pro-Longevity Decrease Apoe
228359 Arhgap1 Rho GTPase activating protein 1 Mus musculus Pro-Longevity Decrease Arhgap1
11865 Arntl aryl hydrocarbon receptor nuclear translocator-like Mus musculus Pro-Longevity Decrease Arntl
11793 Atg5 autophagy related 5 Mus musculus Pro-Longevity 17% Increase Atg5
11920 Atm Ataxia telangiectasia mutated homolog (human) Mus musculus Pro-Longevity Decrease Atm
245000 Atr Ataxia telangiectasia and Rad3 related Mus musculus Pro-Longevity Decrease Atr
12028 Bax Bcl2-associated X protein Mus musculus Unannotated Increase Bax
12189 Brca1 Breast cancer 1 Mus musculus Pro-Longevity Decrease Brca1
12236 Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Bub1b
12237 Bub3 budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) Mus musculus Pro-Longevity 12% Decrease Bub3
12366 Casp2 caspase 2 Mus musculus Pro-Longevity Decrease Casp2
12359 Cat Catalase Mus musculus Pro-Longevity 21% Increase Cat
12389 Cav1 caveolin, caveolae protein 1 Mus musculus Pro-Longevity 50% Decrease Cav1
218294 Cdc14b CDC14 cell division cycle 14B Mus musculus Pro-Longevity Cdc14b
12572 Cdk7 cyclin-dependent kinase 7 Mus musculus Pro-Longevity Decrease Cdk7
12575 Cdkn1a Cyclin-dependent kinase inhibitor 1A Mus musculus Anti-Longevity Increase Cdkn1a
12606 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus Unannotated Increase Cebpa
12608 Cebpb CCAAT/enhancer binding protein (C/EBP), beta Mus musculus Unannotated Increase Cebpb
50883 Chek2 CHK2 checkpoint homolog (S. pombe) Mus musculus Pro-Longevity Decrease Chek2
67006 Cisd2 CDGSH iron sulfur domain 2 Mus musculus Pro-Longevity Increase and Decrease Cisd2
12753 Clock Circadian locomotor output cycles kaput Mus musculus Pro-Longevity 15% Decrease Clock
12842 Col1a1 collagen, type I, alpha 1 Mus musculus Pro-Longevity Decrease Col1a1
12850 Coq7 demethyl-Q 7 Mus musculus Anti-Longevity 30% Increase Coq7
13019 Ctf1 cardiotrophin 1 Mus musculus Anti-Longevity 18% Increase Ctf1
13350 Dgat1 diacylglycerol O-acyltransferase 1 Mus musculus Anti-Longevity 23% Increase Dgat1
13405 Dmd Dystrophin, muscular dystrophy Mus musculus Pro-Longevity 18% Decrease Dmd
66143 Eef1e1 Eukaryotic translation elongation factor 1 epsilon 1 Mus musculus Anti-Longevity 50% Decrease Eef1e1
216616 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Mus musculus Pro-Longevity 20% Decrease Efemp1
208691 Eif5a2 eukaryotic translation initiation factor 5A2 Mus musculus Anti-Longevity Decrease Eif5a2
13860 Eps8 Epidermal growth factor receptor pathway substrate 8 Mus musculus Anti-Longevity 37% Increase Eps8
13870 Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 Mus musculus Pro-Longevity 83% Decrease Ercc1
13871 Ercc2 Excision repair cross-complementing rodent repair deficiency, complementation group 2 Mus musculus Pro-Longevity Decrease Ercc2
50505 Ercc4 Excision repair cross-complementing rodent repair deficiency, complementation group 4 Mus musculus Pro-Longevity Decrease Ercc4
56636 Fgf21 fibroblast growth factor 21 Mus musculus Pro-Longevity 36% Increase Fgf21
64654 Fgf23 Fibroblast growth factor 23 Mus musculus Pro-Longevity Decrease Fgf23
14268 Fn1 Fibronectin 1 Mus musculus Pro-Longevity Decrease Fn1
14235 Foxm1 Forkhead box M1 Mus musculus Pro-Longevity Decrease Foxm1
14297 Fxn frataxin Mus musculus Pro-Longevity Decrease Fxn
2539 G6PD glucose-6-phosphate dehydrogenase Mus musculus Pro-Longevity 14% Increase G6PD
23886 Gdf15 growth differentiation factor 15 Mus musculus Pro-Longevity 43% Increase Gdf15
14599 Gh Growth hormone Mus musculus Anti-Longevity Decrease Gh
14600 Ghr Growth hormone receptor Mus musculus Anti-Longevity 40% Increase Ghr
14601 Ghrh growth hormone releasing hormone Mus musculus Anti-Longevity 46% Increase Ghrh
14602 Ghrhr Growth hormone releasing hormone receptor Mus musculus Anti-Longevity 20% Increase Ghrhr
2764 GMFB glia maturation factor beta Mus musculus Anti-Longevity 6% Decrease GMFB
625249 Gpx4 Glutathione peroxidase 4 Mus musculus Anti-Longevity 7% Increase Gpx4
14824 Grn granulin Mus musculus Pro-Longevity Decrease Grn
606496 Gsk3a glycogen synthase kinase 3 alpha Mus musculus Pro-Longevity Decrease Gsk3a
14860 Gsta4 glutathione S-transferase, alpha 4 Mus musculus Anti-Longevity 13% Increase Gsta4
15201 Hells Proliferation associated SNF-2-like gene Mus musculus Pro-Longevity Decrease Hells
11991 Hnrnpd heterogeneous nuclear ribonucleoprotein D Mus musculus Pro-Longevity Decrease Hnrnpd
15551 Htr1b 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus Pro-Longevity Decrease Htr1b
64704 Htra2 HtrA serine peptidase 2 Mus musculus Pro-Longevity Decrease Htra2
15194 Htt Huntingtin Mus musculus Anti-Longevity 18% Increase Htt
16000 Igf1 Insulin-like growth factor 1 Mus musculus Unclear Increase and Decrease Igf1
16001 Igf1r Insulin-like growth factor 1 receptor Mus musculus Anti-Longevity 40% Increase Igf1r
16150 Ikbkb inhibitor of kappaB kinase beta Mus musculus Anti-Longevity 23% Increase Ikbkb
16337 Insr Insulin receptor Mus musculus Anti-Longevity 33% Increase Insr
16367 Irs1 insulin receptor substrate 1 Mus musculus Anti-Longevity 18% Increase Irs1
384783 Irs2 insulin receptor substrate 2 Mus musculus Anti-Longevity 18% Increase Irs2
16478 Jund Jun proto-oncogene related gene d Mus musculus Pro-Longevity 17% Decrease Jund
16491 Kcna3 Potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus Anti-Longevity 22% Increase Kcna3
16591 Kl Klotho Mus musculus Pro-Longevity Increase and Decrease Kl
16905 Lmna lamin A Mus musculus Unclear Increase and Decrease Lmna
17216 Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Mus musculus Pro-Longevity Decrease Mcm2
107895 Mgat5 mannoside acetylglucosaminyltransferase 5 Mus musculus Pro-Longevity Decrease Mgat5
17319 Mif macrophage migration inhibitory factor Mus musculus Anti-Longevity 16% Increase Mif
723905 Mir17 microRNA 17 Mus musculus Pro-Longevity 16% Increase Mir17
387222 Mir29a microRNA 29a Mus musculus Unannotated Mir29a
387223 Mir29b-1 microRNA 29b-1 Mus musculus Unannotated Mir29b-1
17685 Msh2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) Mus musculus Pro-Longevity Decrease Msh2
110265 Msra Methionine sulfoxide reductase A Mus musculus Pro-Longevity Decrease Msra
17700 Mstn myostatin Mus musculus Anti-Longevity 15% Increase Mstn
17748 Mt1 metallothionein 1 Mus musculus Pro-Longevity 14% Increase Mt1
105837 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein Mus musculus Anti-Longevity 20% Increase Mtbp
56717 Mtor mechanistic target of rapamycin (serine/threonine kinase) Mus musculus Anti-Longevity 20% Increase Mtor
17869 Myc myelocytomatosis oncogene Mus musculus Anti-Longevity 21% Increase Myc
20602 Ncor2 nuclear receptor co-repressor 2 Mus musculus Pro-Longevity 50% Decrease Ncor2
72774 Neil1 nei endonuclease VIII-like 1 (E. coli) Mus musculus Pro-Longevity Decrease Neil1
18033 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus Pro-Longevity 33% Decrease Nfkb1
18127 Nos3 nitric oxide synthase 3, endothelial cell Mus musculus Pro-Longevity Decrease Nos3
4521 NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus Pro-Longevity 16% Increase NUDT1
18491 Pappa Pregnancy-associated plasma protein A Mus musculus Anti-Longevity 30% Increase Pappa
11545 Parp1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) Mus musculus Pro-Longevity 25% Decrease Parp1
114774 Pawr PRKC, apoptosis, WT1, regulator Mus musculus Pro-Longevity Increase and Decrease Pawr
18534 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus Pro-Longevity Increase Pck1
18627 Per2 period circadian clock 2 Mus musculus Anti-Longevity Increase Per2
18792 Plau Plasminogen activator, urokinase Mus musculus Pro-Longevity 20% Increase Plau
18975 Polg Polymerase (DNA directed), gamma Mus musculus Pro-Longevity Decrease Polg
18736 Pou1f1 POU domain, class 1, transcription factor 1 Mus musculus Anti-Longevity 40% Increase Pou1f1
19016 Pparg Peroxisome proliferator activated receptor gamma Mus musculus Pro-Longevity Increase and Decrease Pparg
53892 Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform Mus musculus Pro-Longevity Decrease Ppm1d
18477 Prdx1 Peroxiredoxin 1 Mus musculus Pro-Longevity Decrease Prdx1
19088 Prkar2b protein kinase, cAMP dependent regulatory, type II beta Mus musculus Anti-Longevity 14% Increase Prkar2b
19127 Prop1 Prophet of Pit1, paired-like homeodomain transcription factor Mus musculus Anti-Longevity Increase Prop1
19211 Pten Phosphatase and tensin homolog Mus musculus Pro-Longevity Increase and Decrease Pten
66679 Rae1 RAE1 RNA export 1 homolog (S. pombe) Mus musculus Pro-Longevity Decrease Rae1
56190 Rbm38 RNA binding motif protein 38 Mus musculus Pro-Longevity 22% Decrease Rbm38
78757 Rictor RPTOR independent companion of MTOR, complex 2 Mus musculus Pro-Longevity 40% Decrease Rictor
72508 Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 Mus musculus Anti-Longevity 19% Increase Rps6kb1
18787 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus Anti-Longevity Increase Serpine1
20416 Shc1 SHC (Src homology 2 domain containing) transforming protein 1 Mus musculus Anti-Longevity 30% Increase Shc1
83382 Siglece sialic acid binding Ig-like lectin E Mus musculus Pro-Longevity 17% Decrease Siglece
93759 Sirt1 Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Sirt1
50721 Sirt6 sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Sirt6
209011 Sirt7 Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) Mus musculus Pro-Longevity 59% Decrease Sirt7
55961 Slc13a1 Solute carrier family 13 (sodium/sulfate symporters), member 1 Mus musculus Anti-Longevity 25% Increase Slc13a1
11739 Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus Pro-Longevity Decrease Slc25a4
216233 Socs2 Suppressor of cytokine signaling 2 Mus musculus Pro-Longevity 35% Decrease Socs2
20656 Sod2 Superoxide dismutase 2, mitochondrial Mus musculus Pro-Longevity 43% Decrease Sod2
6649 SOD3 superoxide dismutase 3 Mus musculus Pro-Longevity Decrease SOD3
18412 Sqstm1 sequestosome 1 Mus musculus Pro-Longevity 34% Decrease Sqstm1
56424 Stub1 STIP1 homology and U-Box containing protein 1 Mus musculus Pro-Longevity Decrease Stub1
20930 Surf1 surfeit gene 1 Mus musculus Anti-Longevity 20% Increase Surf1
21750 Terf2 telomeric repeat binding factor 2 Mus musculus Anti-Longevity Decrease Terf2
21752 Tert Telomerase reverse transcriptase Mus musculus Pro-Longevity Increase Tert
21976 Top3b Topoisomerase (DNA) III beta Mus musculus Pro-Longevity Decrease Top3b
106021 Topors Topoisomerase I binding, arginine/serine-rich Mus musculus Pro-Longevity 42% Decrease Topors
22019 Tpp2 Tripeptidyl peptidase II Mus musculus Pro-Longevity Decrease Tpp2
22059 Trp53 Transformation related protein 53 Mus musculus Pro-Longevity 23% Decrease Trp53
27223 Trp53bp1 Transformation related protein 53 binding protein 1 Mus musculus Anti-Longevity Increase Trp53bp1
22061 Trp63 Transformation related protein 63 Mus musculus Pro-Longevity 70% Decrease Trp63
22062 Trp73 transformation related protein 73 Mus musculus Pro-Longevity 31% Decrease Trp73
193034 Trpv1 transient receptor potential cation channel, subfamily V, member 1 Mus musculus Anti-Longevity 16% Increase Trpv1
22166 Txn1 Thioredoxin 1 Mus musculus Pro-Longevity 35% Increase Txn1
24108 Ubd ubiquitin D Mus musculus Anti-Longevity 20% Increase Ubd
22228 Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus Pro-Longevity 20% Increase Ucp2
22590 Xpa Xeroderma pigmentosum, complementation group A Mus musculus Pro-Longevity Decrease Xpa
22596 Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 Mus musculus Pro-Longevity 40% Decrease Xrcc5
14375 Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 Mus musculus Pro-Longevity Decrease Xrcc6
230709 Zmpste24 zinc metallopeptidase, STE24 homolog (S. cerevisiae) Mus musculus Pro-Longevity Decrease Zmpste24