GenAge entry for RAD51 (Homo sapiens)

Gene name (HAGRID: 84)

HGNC symbol
RAD51 
Aliases
HsRad51; HsT16930; BRCC5; FANCR; RAD51A; RECA 
Common name
RAD51 recombinase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

Involved in DNA unwinding and repair [489], RAD51 has been reported to be an important player in the cellular senescence of yeast [192]. Disruption of RAD51 in mice results in embryonic lethality [488]. Its role in mammalian ageing remains unknown.

Cytogenetic information

Cytogenetic band
15q15.1
Location
40,695,129 bp to 40,732,158 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0000730; DNA recombinase assembly
GO:0000731; DNA synthesis involved in DNA repair
GO:0000732; strand displacement
GO:0001932; regulation of protein phosphorylation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006281; DNA repair
GO:0006310; DNA recombination
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
And 22 more GO terms
Cellular component: GO:0000228; nuclear chromosome
GO:0000784; nuclear chromosome, telomeric region
GO:0000785; chromatin
GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0000794; condensed nuclear chromosome
GO:0000800; lateral element
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
And 7 more GO terms
Function: GO:0000150; recombinase activity
GO:0000400; four-way junction DNA binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0042802; identical protein binding
GO:0043142; single-stranded DNA-dependent ATPase activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, WRN, BRCA1, RPA1, BLM, HSP90AA1, ABL1, BRCA2, RAD51, UBE2I, PML, PCNA, RAD52, SP1, SUMO1, H2AFX, ESR1, CDC42
STRING interaction network
Protein-Protein network diagram for RAD51

Retrieve sequences for RAD51

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
rad-51
Danio rerio
rad51
Drosophila melanogaster
spn-A
Mus musculus
Rad51
Rattus norvegicus
LOC100911267
Saccharomyces cerevisiae
RAD51
Schizosaccharomyces pombe
rhp51

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD51
LongevityMap
  • This gene is present as RAD51

Selected references

External links

EPD
HS_RAD51
ORF Accession
NM_002875
CDS Accession
NP_002866
OMIM
179617
HPRD
01557
Ensembl
RAD51
UniProt/Swiss-Prot
RAD51_HUMAN
GeneCards
RAD51
Entrez Gene
5888
UniGene
631709
GenAtlas
RAD51
Internet
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