GenAge entry for VEGFA (Homo sapiens)

Gene name (HAGRID: 77)

HGNC symbol: VEGFA
Aliases: VEGF-A; VPF; VEGF
Common name: vascular endothelial growth factor A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: VEGFA is a growth factor that been widely implicated in age-related changes [1274], tumorigenesis, and neurogenesis [469]. Mutations in the human VEGFA gene have been associated with type 2 diabetes [1674] and atherosclerosis [1675]. Inactivation of VEGFA in mice results in embryonic lethality [470]. It is unclear whether VEGFA is directly involved in ageing, yet it remains a possible player.

Cytogenetic information

Cytogenetic band: 6p12
Location: 43,770,209 bp to 43,786,486 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001525; angiogenesis
GO:0001541; ovarian follicle development
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001570; vasculogenesis
GO:0001666; response to hypoxia
GO:0001701; in utero embryonic development
GO:0001822; kidney development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002042; cell migration involved in sprouting angiogenesis

And 80 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0016020; membrane
GO:0030141; secretory granule
GO:0031093; platelet alpha granule lumen

Function:

GO:0001968; fibronectin binding
GO:0005125; cytokine activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005172; vascular endothelial growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043183; vascular endothelial growth factor receptor 1 binding

And 5 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: HSP90AA1, VEGFA, FLT1, CTGF
STRING interaction network

Retrieve sequences for VEGFA

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: vegfab
Danio rerio: vegfaa
Mus musculus: Vegfa
Rattus norvegicus: Vegfa

In other databases

LongevityMap

This gene is present as VEGFA

CellAge

This gene is present as VEGFA