GenAge entry for ERBB2 (Homo sapiens)

Gene name (HAGRID: 41)

HGNC symbol
ERBB2 
Aliases
NEU; HER-2; CD340; HER2; NGL 
Common name
erb-b2 receptor tyrosine kinase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

A component of the NRG1-receptor complex, ERBB2 is considered an oncogene and it promotes cellular growth and survival [271]. Though it is not significantly active in adult tissues, ERBB2 has been linked to cancer and may be associated with age-related changes in the nervous system [273].

Cytogenetic information

Cytogenetic band
17q12
Location
39,699,978 bp to 39,728,662 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0001934; positive regulation of protein phosphorylation
GO:0006351; transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0007167; enzyme linked receptor protein signaling pathway
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422; peripheral nervous system development
GO:0007507; heart development
GO:0007528; neuromuscular junction development
And 29 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0010008; endosome membrane
GO:0016021; integral component of membrane
GO:0016323; basolateral plasma membrane
GO:0016324; apical plasma membrane
GO:0043209; myelin sheath
GO:0043235; receptor complex
GO:0048471; perinuclear region of cytoplasm
Function: GO:0001042; RNA polymerase I core binding
GO:0004713; protein tyrosine kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888; transmembrane signaling receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0019838; growth factor binding
GO:0019903; protein phosphatase binding
And 6 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, IGF1R, PTPN11, STAT3, NRG1, IRS1, EGFR, ERBB2, EGF, PLCG2, PIN1, HSP90AA1, ABL1, GRB2, PTK2B, PTK2, PIK3R1, JAK2, ESR1, CTNNB1, STUB1
STRING interaction network
Protein-Protein network diagram for ERBB2

Retrieve sequences for ERBB2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
erbb2
Drosophila melanogaster
Egfr
Mus musculus
Erbb2
Rattus norvegicus
Erbb2

In other databases

LongevityMap
  • This gene is present as ERBB2

Selected references

External links

EPD
HS_ERBB2_2
ORF Accession
NM_004448
CDS Accession
NP_004439
OMIM
164870
HPRD
01281
Ensembl
ERBB2
UniProt/Swiss-Prot
ERBB2_HUMAN
GeneCards
ERBB2
Entrez Gene
2064
UniGene
446352
GenAtlas
ERBB2
Internet
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