GenAge entry for EGFR (Homo sapiens)

Gene name (HAGRID: 40)

HGNC symbol
EGFR 
Aliases
ERBB1; ERBB 
Common name
epidermal growth factor receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

EGFR is a glycoprotein and oncogene involved in cell proliferation. It has been associated with age-related declines in stress-response [1161], but it is not known whether this is a cause or effect of ageing. EGFR has also been related to age-related declines in rat hepatocytes [346]. Whether EGFR plays a role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
7p12
Location
55,019,032 bp to 55,207,338 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0001503; ossification
GO:0001892; embryonic placenta development
GO:0001934; positive regulation of protein phosphorylation
GO:0001942; hair follicle development
GO:0006412; translation
GO:0006950; response to stress
GO:0006970; response to osmotic stress
GO:0006979; response to oxidative stress
GO:0007165; signal transduction
And 78 more GO terms
Cellular component: GO:0000139; Golgi membrane
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005768; endosome
GO:0005789; endoplasmic reticulum membrane
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0010008; endosome membrane
And 14 more GO terms
Function: GO:0001948; glycoprotein binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0004709; MAP kinase kinase kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888; transmembrane signaling receptor activity
GO:0005006; epidermal growth factor-activated receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005178; integrin binding
And 15 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, IGF1R, TXN, PTPN11, STAT5B, STAT3, STAT5A, IRS1, PTPN1, IRS2, AKT1, PIK3CB, EGFR, ERBB2, NRG1, EGF, FOS, PDGFRB, RET, PLCG2, RPA1, BLM, HSP90AA1, ABL1, PML, HTT, PRKCA, PRKDC, AR, XRCC5, PCNA, HSPA8, EMD, GRB2, AIFM1, UCHL1, APP, PRDX1, HSPA1A, HSPA1B, MAPK8, YWHAZ, PTK2B, PTK2, MAPK14, MAPK9, PIK3R1, EEF1A1, JAK2, HSPA9, CDK1, CTGF, H2AFX, NR3C1, HELLS, CEBPB, ESR1, CLU, MTOR, CTNNB1, MAPT, GCLM, BUB3, ATR, STUB1, ARHGAP1, PPARGC1A, PPARG, EPS8, PDGFRA, GRN, TRPV1
STRING interaction network
Protein-Protein network diagram for EGFR

Retrieve sequences for EGFR

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Egfr
Rattus norvegicus
Egfr

In other databases

LongevityMap
  • This gene is present as EGFR

Selected references

External links

EPD
HS_EGFR_2
ORF Accession
NM_005228
CDS Accession
NP_005219
OMIM
131550
HPRD
00579
Ensembl
EGFR
UniProt/Swiss-Prot
EGFR_HUMAN
GeneCards
EGFR
Entrez Gene
1956
UniGene
488293
GenAtlas
EGFR
Internet
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