GenAge entry for NUDT1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 296)

HGNC symbol
NUDT1 
Aliases
MTH1 
Common name
nudix (nucleoside diphosphate linked moiety X)-type motif 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

NUDT1 degrades oxidative damage to DNA and RNA. Mice defective in NUDT1 develop spontaneous tumours [3430]. Mice overexpressing human NUDT1 have lower levels of DNA damage and live 16% longer [3257], suggesting a role in ageing. Further studies are necessary, however.

Cytogenetic information

Cytogenetic band
7p22
Location
2,242,221 bp to 2,251,145 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006195; purine nucleotide catabolic process
GO:0006203; dGTP catabolic process
GO:0006281; DNA repair
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0008584; male gonad development
GO:0034656; nucleobase-containing small molecule catabolic process
GO:0042262; DNA protection
GO:0046061; dATP catabolic process
GO:0046686; response to cadmium ion
Cellular component: GO:0001669; acrosomal vesicle
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031965; nuclear membrane
GO:0070062; extracellular exosome
Function: GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0008413; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0030515; snoRNA binding
GO:0035539; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0036219; GTP diphosphatase activity
GO:0044713; 2-hydroxy-adenosine triphosphate pyrophosphatase activity
GO:0044714; 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
GO:0046872; metal ion binding
GO:0047693; ATP diphosphatase activity
GO:0050072; m7G(5')pppN diphosphatase activity
And 1 more GO terms
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for NUDT1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nudt1
Mus musculus
Nudt1
Rattus norvegicus
Nudt1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as NUDT1

Selected references

External links

EPD
ORF Accession
NM_002452
CDS Accession
NP_002443
OMIM
600312
HPRD
02634
Ensembl
NUDT1
UniProt/Swiss-Prot
8ODP_HUMAN
GeneCards
NUDT1
Entrez Gene
4521
UniGene
534331
GenAtlas
NUDT1
Internet
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