GenAge entry for MIF (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 290)

HGNC symbol
MIF 
Aliases
GIF; GLIF 
Common name
macrophage migration inhibitory factor (glycosylation-inhibiting factor) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

MIF is involved in several processes, including in cell proliferation and inflammation. Its levels are elevated in long-lived mouse models, including in caloric restriction. Knocking out MIF in mice results in an extended lifespan (knockout mice live 16% longer than controls) and are even longer-lived under caloric restriction [3248]. These results suggest a potential role in ageing, though human studies are lacking.

Cytogenetic information

Cytogenetic band
22q11.23
Location
23,894,378 bp to 23,895,222 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001516; prostaglandin biosynthetic process
GO:0002906; negative regulation of mature B cell apoptotic process
GO:0006954; inflammatory response
GO:0007166; cell surface receptor signaling pathway
GO:0007569; cell aging
GO:0008283; cell proliferation
GO:0010629; negative regulation of gene expression
GO:0010739; positive regulation of protein kinase A signaling
GO:0019752; carboxylic acid metabolic process
GO:0030330; DNA damage response, signal transduction by p53 class mediator
GO:0030890; positive regulation of B cell proliferation
And 25 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0031982; vesicle
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
Function: GO:0004167; dopachrome isomerase activity
GO:0005102; receptor binding
GO:0005125; cytokine activity
GO:0005126; cytokine receptor binding
GO:0005515; protein binding
GO:0042056; chemoattractant activity
GO:0050178; phenylpyruvate tautomerase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, HSP90AA1, PCMT1, STUB1, MIF
STRING interaction network
Protein-Protein network diagram for MIF

Retrieve sequences for MIF

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mif-1
Danio rerio
mif
Mus musculus
Mif
Rattus norvegicus
RGD1560513

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Mif

Selected references

External links

EPD
HS_MIF
ORF Accession
NM_002415
CDS Accession
NP_002406
OMIM
153620
HPRD
01091
Ensembl
MIF
UniProt/Swiss-Prot
I4AY87_HUMAN
GeneCards
MIF
Entrez Gene
4282
UniGene
407995
GenAtlas
MIF
Internet
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