GenAge entry for CDKN2B (Homo sapiens)

Gene name (HAGRID: 288)

HGNC symbol
CDKN2B 
Aliases
P15; MTS2; INK4B; TP15; CDK4I; p15INK4b 
Common name
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

The p15 tumor suppressor (CDKN2B) is located in the same region as p16 (CDKN2A), and is also involved in cell cycle, senescence and cancer. This region is frequently mutated and/or deleted in a wide variety of tumors [2229]. Genetic variants have been identified close to both p15 and p16 in patients with type 2 diabetes and cardiovascular disease [2230]. Although CDKN2B seems to have a role in cellular senescence and age-related diseases, its implication in broader aspects of ageing is still unknown.

Cytogenetic information

Cytogenetic band
9p21
Location
22,002,903 bp to 22,009,313 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007050; cell cycle arrest
GO:0007093; mitotic cell cycle checkpoint
GO:0008285; negative regulation of cell proliferation
GO:0030219; megakaryocyte differentiation
GO:0030511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031668; cellular response to extracellular stimulus
GO:0031670; cellular response to nutrient
GO:0042326; negative regulation of phosphorylation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
And 5 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515; protein binding
GO:0019901; protein kinase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
APP
STRING interaction network
Protein-Protein network diagram for CDKN2B

Retrieve sequences for CDKN2B

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC100329528
Mus musculus
Cdkn2b
Rattus norvegicus
Cdkn2b

In other databases

LongevityMap
  • This gene is present as CDKN2B
CellAge
  • This gene is present as CDKN2B

Selected references

External links

EPD
ORF Accession
NM_004936
CDS Accession
NP_004927
OMIM
600431
HPRD
02696
Ensembl
CDKN2B
UniProt/Swiss-Prot
CDN2B_HUMAN
GeneCards
CDKN2B
Entrez Gene
1030
UniGene
72901
GenAtlas
CDKN2B
Internet
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