GenAge entry for C1QA (Homo sapiens)

Gene name (HAGRID: 287)

HGNC symbol
C1QA 
Aliases
 
Common name
complement component 1, q subcomponent, A chain 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

C1QA activates Wnt signaling, which has been implicated in mammalian ageing, and promotes ageing-associated decline in tissue regeneration. Serum C1q concentration is increased with ageing, and Wnt signaling activity is augmented during ageing in the serum and in multiple tissues of wild-type mice, but not in C1qa-deficient mice. Skeletal muscle regeneration in young mice is inhibited by exogenous C1q treatment, whereas ageing-associated impairment of muscle regeneration is restored by C1s inhibition or C1qa gene disruption [2228]. C1q protein levels dramatically increase in the normal aging mouse and human brain, by as much as 300-fold, in the hippocampus, substantia nigra, and piriform cortex. Moreover, C1q-deficient mice exhibit less cognitive decline in compared with wild-type mice [3588].

Cytogenetic information

Cytogenetic band
1p36.12
Location
22,636,625 bp to 22,639,682 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006956; complement activation
GO:0006958; complement activation, classical pathway
GO:0007267; cell-cell signaling
GO:0045087; innate immune response
Cellular component: GO:0005576; extracellular region
GO:0005581; collagen
GO:0005602; complement component C1 complex
Function: GO:0005515; protein binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for C1QA

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
C1qa
Rattus norvegicus
C1qa

In other databases

GenAge microarray genes
  • This gene is present as C1QA

Selected references

External links

EPD
ORF Accession
NM_015991
CDS Accession
NP_057075
OMIM
120550
HPRD
00393
Ensembl
C1QA
UniProt/Swiss-Prot
C1QA_HUMAN
GeneCards
C1QA
Entrez Gene
712
UniGene
632379
GenAtlas
C1QA
Internet
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