GenAge entry for TP73 (Homo sapiens)

Gene name (HAGRID: 281)

HGNC symbol
TP73 
Aliases
P73 
Common name
tumor protein p73 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

The tumor suppressor TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and participates in the apoptotic response to DNA damage. Compared to p53-deficient mice, p73-deficient mice also exhibited profound defects, including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, as well as abnormalities in pheromone sensory pathways, but showed no increased susceptibility to spontaneous tumorigenesis [2203]. Old p73 +/- mice are more susceptible to neurodegeneration and showed decreased cognitive and motor function, brain atrophy, and neuronal degeneration compared to wild type [2204]. Mice lacking one of the isoforms (DeltaNp73) are viable and fertile but display the signs of neurodegeneration. Cells from these mice are more sensible to DNA-damage and have an increased p53-dependent apoptosis [2205]. Therefore, it is possible that TP73 plays a role in some aspects of ageing, in particular in the brain.

Cytogenetic information

Cytogenetic band
1p36.3
Location
3,698,046 bp to 3,736,201 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000187; activation of MAPK activity
GO:0001822; kidney development
GO:0006298; mismatch repair
GO:0006366; transcription from RNA polymerase II promoter
GO:0006974; cellular response to DNA damage stimulus
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050; cell cycle arrest
GO:0007346; regulation of mitotic cell cycle
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165; response to X-ray
And 21 more GO terms
Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005739; mitochondrion
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0030054; cell junction
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0002039; p53 binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0042802; identical protein binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, BRCA1, PIN1, CREBBP, ABL1, UBE2I, EP300, RB1, SIRT1, HDAC1, HSPA9, HMGB1, CCNA2, BUB1B, HDAC2, MDM2, SUMO1, TP53BP1, TP73, IKBKB
STRING interaction network
Protein-Protein network diagram for TP73

Retrieve sequences for TP73

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
tp73
Mus musculus
Tp73
Rattus norvegicus
Tp73

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Trp73

Selected references

External links

EPD
ORF Accession
NM_001204192
CDS Accession
NP_001191121
OMIM
601990
HPRD
03587
Ensembl
TP73
UniProt/Swiss-Prot
C9J521_HUMAN
GeneCards
TP73
Entrez Gene
7161
UniGene
192132
GenAtlas
TP73
Internet
Search Google