GenAge entry for NCOR2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 276)

HGNC symbol
NCOR2 
Aliases
SMRT; SMRTE; TRAC-1; CTG26; TNRC14 
Common name
nuclear receptor corepressor 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. Additionally, in a preliminary analysis, several human polymorphisms were found to be associated with type 2 diabetes [2196].

Cytogenetic information

Cytogenetic band
12q24
Location
124,324,411 bp to 124,567,464 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0044255; cellular lipid metabolic process
GO:0072365; regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
Cellular component: GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0016604; nuclear body
GO:0017053; transcriptional repressor complex
Function: GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005112; Notch binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0042826; histone deacetylase binding
GO:0047485; protein N-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
E2F1, HDAC3, AKT1, NCOR1, FOS, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, AR, RELA, HDAC1, SP1, JUN, SIN3A, HDAC2, SUMO1, ESR1, NFKBIA, PPARG, NFE2L2, CDKN1A
STRING interaction network
Protein-Protein network diagram for NCOR2

Retrieve sequences for NCOR2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ncor2
Mus musculus
Ncor2
Rattus norvegicus
Ncor2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ncor2

Selected references

External links

EPD
ORF Accession
NM_001206654
CDS Accession
NP_001193583
OMIM
600848
HPRD
02910
Ensembl
NCOR2
UniProt/Swiss-Prot
C9J0Q5_HUMAN
GeneCards
NCOR2
Entrez Gene
9612
UniGene
137510
GenAtlas
NCOR2
Internet
Search Google