GenAge entry for SOCS2 (Homo sapiens)

Gene name (HAGRID: 271)

HGNC symbol
SOCS2 
Aliases
STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2 
Common name
suppressor of cytokine signaling 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family and is a cytokine-inducible negative regulator of cytokine receptor signaling through the JAK/STAT pathway. The SOCS2 protein interacts with IGF1 and GH receptors IGF1R and GHR [2175] as a negative regulator of GH signaling [2177]. The lack of SOCS2 expression in the high-growth mouse increases plasma IGF1, and reduces plasma and pituitary GH1 levels. Mutant mice exhibited a reduced mean and maximal lifespan compared to wild type [2178]. SOCS2 is also involved in several types of cancer [2179].

Cytogenetic information

Cytogenetic band
12q
Location
93,569,822 bp to 93,576,745 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001558; regulation of cell growth
GO:0006469; negative regulation of protein kinase activity
GO:0007259; JAK-STAT cascade
GO:0009966; regulation of signal transduction
GO:0009967; positive regulation of signal transduction
GO:0016567; protein ubiquitination
GO:0019221; cytokine-mediated signaling pathway
GO:0032355; response to estradiol
GO:0032870; cellular response to hormone stimulus
GO:0043066; negative regulation of apoptotic process
GO:0046426; negative regulation of JAK-STAT cascade
And 3 more GO terms
Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004860; protein kinase inhibitor activity
GO:0005070; SH3/SH2 adaptor activity
GO:0005131; growth hormone receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0008269; JAK pathway signal transduction adaptor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, IGF1R, EPOR, PTK2B, PTK2, BMI1
STRING interaction network
Protein-Protein network diagram for SOCS2

Retrieve sequences for SOCS2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
socs2
Mus musculus
Gm9847
Rattus norvegicus
Socs2

In other databases

LongevityMap
  • This gene is present as SOCS2

Selected references

External links

EPD
ORF Accession
NM_003877
CDS Accession
NP_003868
OMIM
605117
HPRD
05490
Ensembl
SOCS2
UniProt/Swiss-Prot
SOCS2_HUMAN
GeneCards
SOCS2
Entrez Gene
8835
UniGene
485572
GenAtlas
SOCS2
Internet
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