GenAge entry for PPARG (Homo sapiens)

Gene name (HAGRID: 263)

HGNC symbol
PPARG 
Aliases
PPARG1; PPARG2; NR1C3; PPARgamma 
Common name
peroxisome proliferator-activated receptor gamma 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Peroxisome proliferator-activated receptor (PPAR)gamma-2 is an important regulator of adipose tissue metabolism, insulin sensitivity and inflammatory response. Recent studies have identified klotho (KL) as a target gene for peroxisome proliferator-activated receptor-gamma (PPARg) [2141]. Mutant mice with a lowered expression of Pparg had a reduced lifespan compared to wild type [2142], however adipose tissue-specific PPARg heterozygous mice exhibited significant improvement in insulin sensitivity in skeletal muscle and showed an increased resistance to paraquat-induced oxidative stress [3665]. The level of PPARs (including PPARG) is reduced with age and caloric restriction in mice appears to prevent these alteration, suggesting common mechanisms [2143].

Mutations in PPARG may be one of the causes of type 2 insulin-resistant diabetes and hyptertension [2144] and a polymorphism of PPARG has been associated to early atherosclerosis [2145]. Defects in PPARG may also be associated with colon cancer [2146]. Genome-wide association studies have identified a paraoxonase Pro/Ala gene polyporphism which is associated to human longevity [2147].

Cytogenetic information

Cytogenetic band
3p25
Location
12,287,850 bp to 12,434,356 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001890; placenta development
GO:0002674; negative regulation of acute inflammatory response
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006629; lipid metabolic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165; signal transduction
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007507; heart development
GO:0007584; response to nutrient
GO:0008217; regulation of blood pressure
And 56 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
GO:0090575; RNA polymerase II transcription factor complex
Function: GO:0001046; core promoter sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003707; steroid hormone receptor activity
GO:0004879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004955; prostaglandin receptor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008144; drug binding
GO:0008270; zinc ion binding
And 12 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, STAT5A, HDAC3, EGFR, NCOR1, JUND, PIN1, CREBBP, IGFBP3, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, PRKCA, XRCC5, XRCC6, RB1, APP, RELA, HDAC1, SP1, JUN, MED1, TFAP2A, MDM2, CTNNB1, PPARGC1A, PPARG, NCOR2, IKBKB
STRING interaction network
Protein-Protein network diagram for PPARG

Retrieve sequences for PPARG

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
pparg
Mus musculus
Pparg
Rattus norvegicus
Pparg

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pparg
LongevityMap
  • This gene is present as PPARG

Selected references

External links

EPD
ORF Accession
NM_005037
CDS Accession
NP_005028
OMIM
601487
HPRD
03288
Ensembl
PPARG
UniProt/Swiss-Prot
D2KUA6_HUMAN
GeneCards
PPARG
Entrez Gene
5468
UniGene
162646
GenAtlas
PPARG
Internet
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