GenAge entry for STUB1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 245)

HGNC symbol
STUB1 
Aliases
UBOX1; CHIP; SDCCAG7; HSPABP2; NY-CO-7 
Common name
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

STUB1 is involved in proteasomal degradation by targeting misfolded chaperone substrates and interacting with chaperone complexes, including HSPA8, thus contributing to protein quality control.

STUB1-null mice exhibit a deregulation of protein quality control. They have a short lifespan and accelerated age-related pathophysiological features [1836], suggesting a potential role of STUB1 in ageing.

Cytogenetic information

Cytogenetic band
16p13.3
Location
680,111 bp to 682,768 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000209; protein polyubiquitination
GO:0006281; DNA repair
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0006515; misfolded or incompletely synthesized protein catabolic process
GO:0016567; protein ubiquitination
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579; ubiquitin-dependent SMAD protein catabolic process
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031398; positive regulation of protein ubiquitination
GO:0031647; regulation of protein stability
GO:0031943; regulation of glucocorticoid metabolic process
And 13 more GO terms
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0030018; Z disc
GO:0031371; ubiquitin conjugating enzyme complex
GO:0042405; nuclear inclusion body
GO:0045111; intermediate filament cytoskeleton
GO:0070062; extracellular exosome
And 1 more GO terms
Function: GO:0001664; G-protein coupled receptor binding
GO:0004842; ubiquitin-protein transferase activity
GO:0005515; protein binding
GO:0016874; ligase activity
GO:0019899; enzyme binding
GO:0019900; kinase binding
GO:0030544; Hsp70 protein binding
GO:0030674; protein binding, bridging
GO:0030911; TPR domain binding
GO:0031625; ubiquitin protein ligase binding
GO:0034450; ubiquitin-ubiquitin ligase activity
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, TP53, TERT, AKT1, MYC, EGFR, ERBB2, PTEN, HIF1A, HSP90AA1, ABL1, STK11, TERF1, AR, TERF2, HSPA8, FOXO1, HSF1, SOD1, APP, HSPD1, HSPA1A, HSPA1B, PTK2, MAP3K5, RELA, VCP, NR3C1, ESR1, MAPT, POLB, SIRT6, STUB1, MIF, SQSTM1
STRING interaction network
Protein-Protein network diagram for STUB1

Retrieve sequences for STUB1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
chn-1
Danio rerio
stub1
Drosophila melanogaster
CHIP
Mus musculus
Stub1
Rattus norvegicus
Stub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Stub1
  • A homolog of this gene for Caenorhabditis elegans is present as chn-1

Selected references

External links

EPD
HS_STUB1
ORF Accession
NM_005861
CDS Accession
NP_005852
OMIM
607207
HPRD
06232
Ensembl
STUB1
UniProt/Swiss-Prot
STUB1_HUMAN
GeneCards
STUB1
Entrez Gene
10273
UniGene
592081
GenAtlas
STUB1
Internet
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