GenAge entry for ZMPSTE24 (Homo sapiens)

Gene name (HAGRID: 233)

HGNC symbol
ZMPSTE24 
Aliases
FACE-1; Ste24p; STE24; HGPS; PRO1 
Common name
zinc metallopeptidase STE24 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

ZMPSTE24 is a zinc metalloprotease involved in the post-translational processing of LMNA precursors. ZMPSTE24-null mice have a short lifespan and show some signs of accelerated ageing. Disruption of TP53 in ZMPSTE24-null mice partly alleviates these symptoms [1472]. Mutations in ZMPSTE24 have been associated with human diseases, often due to the accumulation of LMNA precursors [1477]. It is possible that ZMPSTE24, maybe due to its association with LMNA, plays some role in human ageing.

Cytogenetic information

Cytogenetic band
1p34
Location
40,258,050 bp to 40,294,184 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006508; proteolysis
GO:0006998; nuclear envelope organization
GO:0030327; prenylated protein catabolic process
GO:0071586; CAAX-box protein processing
Cellular component: GO:0005637; nuclear inner membrane
GO:0016020; membrane
GO:0030176; integral component of endoplasmic reticulum membrane
GO:0070062; extracellular exosome
Function: GO:0004222; metalloendopeptidase activity
GO:0008235; metalloexopeptidase activity
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PTPN1
STRING interaction network
Protein-Protein network diagram for ZMPSTE24

Retrieve sequences for ZMPSTE24

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
fce-1
Danio rerio
zmpste24
Drosophila melanogaster
ste24a
Mus musculus
Zmpste24
Rattus norvegicus
Zmpste24
Saccharomyces cerevisiae
STE24
Schizosaccharomyces pombe
SPAC3H1.05

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Zmpste24

Selected references

External links

EPD
ORF Accession
NM_005857
CDS Accession
NP_005848
OMIM
606480
HPRD
07349
Ensembl
ZMPSTE24
UniProt/Swiss-Prot
FACE1_HUMAN
GeneCards
ZMPSTE24
Entrez Gene
10269
UniGene
132642
GenAtlas
ZMPSTE24
Internet
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