GenAge entry for CLU (Homo sapiens)

Gene name (HAGRID: 220)

HGNC symbol
CLU 
Aliases
SGP-2; SP-40; TRPM-2; KUB1; CLU1; CLU2; CLI; APOJ 
Common name
clusterin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

The functions of CLU are still unclear, but it may be involved in apoptosis. In flies, overexpression of human clusterin increased stress resistance and significantly extended lifespan [2116]. CLU-null mice had 50% less brain injury following neonatal hypoxia-ischemia [1748]. Inflammation was more severe in CLU-deficient mice [1749].

In humans, serum levels of CLU increase during type 2 diabetes and coronary heart disease [1230] and genome-wide association studies have identified variants of CLU to be associated with Alzheimer's disease [2003][2004]. There is however no direct evidence linking CLU to human ageing.

Cytogenetic information

Cytogenetic band
8p21-p12
Location
27,596,917 bp to 27,615,031 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000902; cell morphogenesis
GO:0001774; microglial cell activation
GO:0001836; release of cytochrome c from mitochondria
GO:0002576; platelet degranulation
GO:0006629; lipid metabolic process
GO:0006956; complement activation
GO:0006958; complement activation, classical pathway
GO:0009615; response to virus
GO:0017038; protein import
GO:0032286; central nervous system myelin maintenance
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
And 22 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0009986; cell surface
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen
And 10 more GO terms
Function: GO:0005515; protein binding
GO:0016887; ATPase activity
GO:0031625; ubiquitin protein ligase binding
GO:0051087; chaperone binding
GO:0051787; misfolded protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, FOS, NFKB1, TNF, XRCC6, BAX, GRB2, LRP2, APP, PON1, HSPD1, MAPK9, MDM2, H2AFX, NFKBIA, CLU, ELN, PDGFRA
STRING interaction network
Protein-Protein network diagram for CLU

Retrieve sequences for CLU

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
clu
Mus musculus
Clu
Rattus norvegicus
Clu

In other databases

GenAge microarray genes
  • This gene is present as CLU
LongevityMap
  • This gene is present as CLU

Selected references

External links

EPD
ORF Accession
NM_203339
CDS Accession
NP_976084
OMIM
185430
HPRD
01706
Ensembl
CLU
UniProt/Swiss-Prot
CLUS_HUMAN
GeneCards
CLU
Entrez Gene
1191
UniGene
436657
GenAtlas
CLU
Internet
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