GenAge entry for MDM2 (Homo sapiens)

Gene name (HAGRID: 210)

HGNC symbol
MDM2 
Aliases
HDM2; MGC5370 
Common name
MDM2 proto-oncogene, E3 ubiquitin protein ligase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

MDM2 is an oncogene that inhibits TP53 [890]. The MDM2 gene encodes multiple transcripts, many of which are tissue-specific. Disruption of MDM2 in mice resulted in increased TP53-dependent apoptosis and defects in multiple haematopoietic lineages [889]. Mutations in the human MDM2 gene have been associated with cancer [1738]. A role for MDM2 in human ageing is unknown.

Cytogenetic information

Cytogenetic band
12q14.3-q1
Location
68,808,172 bp to 68,845,544 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001568; blood vessel development
GO:0001974; blood vessel remodeling
GO:0002027; regulation of heart rate
GO:0003181; atrioventricular valve morphogenesis
GO:0003203; endocardial cushion morphogenesis
GO:0003281; ventricular septum development
GO:0003283; atrial septum development
GO:0006461; protein complex assembly
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089; traversing start control point of mitotic cell cycle
And 48 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0016604; nuclear body
GO:0030666; endocytic vesicle membrane
GO:0043234; protein complex
GO:0045202; synapse
Function: GO:0002039; p53 binding
GO:0004842; ubiquitin-protein transferase activity
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0016874; ligase activity
GO:0019789; SUMO transferase activity
GO:0019899; enzyme binding
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0042975; peroxisome proliferator activated receptor binding
GO:0061630; ubiquitin protein ligase activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, ATM, ERCC8, IGF1R, AKT1, CREBBP, HIF1A, S100B, HSP90AA1, EGR1, ABL1, TOP1, UBE2I, ERCC6, EP300, PML, GSK3B, EEF2, AR, PCNA, XRCC6, HSPA8, RB1, FOXO3, FOXO1, UCHL1, APP, HDAC1, PTK2, JUN, MED1, SDHC, FOXO4, EEF1A1, TBP, APEX1, E2F1, MDM2, TAF1, RELA, VCP, JUND, NBN, SUMO1, NR3C1, BUB1B, ESR1, CLU, CDKN2A, PPP1CA, TP63, SIRT6, PPM1D, CHEK2, PPARG, TP73, CDKN1A
STRING interaction network
Protein-Protein network diagram for MDM2

Retrieve sequences for MDM2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
mdm2
Mus musculus
Mdm2
Rattus norvegicus
Mdm2

In other databases

LongevityMap
  • This gene is present as MDM2

Selected references

External links

EPD
ORF Accession
NM_002392
CDS Accession
NP_002383
OMIM
164785
HPRD
01272
Ensembl
MDM2
UniProt/Swiss-Prot
MDM2_HUMAN
GeneCards
MDM2
Entrez Gene
4193
UniGene
567303
GenAtlas
MDM2
Internet
Search Google