GenAge entry for PON1 (Homo sapiens)

Gene name (HAGRID: 142)

HGNC symbol
PON1 
Aliases
ESA; PON 
Common name
paraoxonase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

PON1 hydrolyzes toxic compounds and is associated with high-density lipoproteins. Mice without PON1 are more susceptible to some toxic agents and, when fed a high-fat, high-cholesterol diet, display atherosclerosis [708]. Allelic variants in the human PON1 gene have been linked to longevity [706] and neurodegenerative diseases [707]. A role in human ageing is possible even if unverified.

Cytogenetic information

Cytogenetic band
7q21.3
Location
95,298,357 bp to 95,324,572 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0008203; cholesterol metabolic process
GO:0009605; response to external stimulus
GO:0009636; response to toxic substance
GO:0010875; positive regulation of cholesterol efflux
GO:0016311; dephosphorylation
GO:0019439; aromatic compound catabolic process
GO:0031667; response to nutrient levels
GO:0032411; positive regulation of transporter activity
GO:0034445; negative regulation of plasma lipoprotein particle oxidation
GO:0046395; carboxylic acid catabolic process
GO:0046434; organophosphate catabolic process
And 5 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0034364; high-density lipoprotein particle
GO:0034366; spherical high-density lipoprotein particle
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
Function: GO:0004063; aryldialkylphosphatase activity
GO:0004064; arylesterase activity
GO:0005509; calcium ion binding
GO:0005543; phospholipid binding
GO:0042803; protein homodimerization activity
GO:0102007; acyl-L-homoserine-lactone lactonohydrolase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CLU
STRING interaction network
Protein-Protein network diagram for PON1

Retrieve sequences for PON1

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Pon1
Rattus norvegicus
Pon1

In other databases

LongevityMap
  • This gene is present as PON1

Selected references

External links

EPD
ORF Accession
NM_000446
CDS Accession
NP_000437
OMIM
168820
HPRD
01351
Ensembl
PON1
UniProt/Swiss-Prot
PON1_HUMAN
GeneCards
PON1
Entrez Gene
5444
UniGene
370995
GenAtlas
PON1
Internet
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