GenAge entry for A2M (Homo sapiens)

Gene name (HAGRID: 139)

HGNC symbol: A2M
Aliases: FWP007; S863-7; CPAMD5
Common name: alpha-2-macroglobulin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: A2M inhibits proteinases. Knockout mice are more resistant to endotoxins [702], though they have not been shown to live longer. In humans, A2M has been associated with neurodegenerative diseases [703], but a direct association with human ageing has not been established.

Cytogenetic information

Cytogenetic band: 12p13.31
Location: 9,067,708 bp to 9,115,962 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001869; negative regulation of complement activation, lectin pathway
GO:0002576; platelet degranulation
GO:0007597; blood coagulation, intrinsic pathway
GO:0010951; negative regulation of endopeptidase activity
GO:0022617; extracellular matrix disassembly
GO:0043547; positive regulation of GTPase activity
GO:0048863; stem cell differentiation
GO:0051056; regulation of small GTPase mediated signal transduction

Cellular component:

GO:0005576; extracellular region
GO:0005829; cytosol
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome
GO:0072562; blood microparticle

Function:	GO:0002020; protease binding GO:0004867; serine-type endopeptidase inhibitor activity GO:0005096; GTPase activator activity GO:0005102; receptor binding GO:0005515; protein binding GO:0019838; growth factor binding GO:0019899; enzyme binding GO:0019959; interleukin-8 binding GO:0019966; interleukin-1 binding GO:0043120; tumor necrosis factor binding GO:0048306; calcium-dependent protein binding
	And 1 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: NGF, GRB2, APP, APOE, A2M, H2AFX, LEP, TP63, CDC42, CDKN1A, CDK7
STRING interaction network

Retrieve sequences for A2M

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: 100101650
Danio rerio: 793100
Danio rerio: CABZ01075618.1
Danio rerio: 562067
Danio rerio: 566238
Danio rerio: 100003785
Danio rerio: 100006782
Danio rerio: zgc:171426
Danio rerio: si:ch211-212c13.8
Danio rerio: 100136837
Danio rerio: a2ml
Danio rerio: 100006947
Danio rerio: 793035
Drosophila melanogaster: Mcr
Drosophila melanogaster: Tep2
Drosophila melanogaster: Tep3
Drosophila melanogaster: Tep1
Drosophila melanogaster: Tep4
Drosophila melanogaster: Tep5
Mus musculus: A2m
Rattus norvegicus: LOC100911545
Rattus norvegicus: A2m