GenAge entry for SOD1 (Homo sapiens)

Gene name (HAGRID: 130)

HGNC symbol
SOD1 
Aliases
IPOA; ALS; ALS1 
Common name
superoxide dismutase 1, soluble 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

SOD1 is an antioxidant, the SOD form predominant in the cytoplasm. Results from invertebrates suggest a role for SOD1 in ageing. Overexpression of SOD1 and CAT in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40]. SOD1-null mice develop normally, do not show signs of premature ageing, but are vulnerable to motor neuron loss after axonal injury [45]. SMP30RGN/SOD1-double knockout mice exhibit abnormal plasma lipid metabolism, hepatic lipid accumulation and premature death resulting from impaired VLDL secretion, both compared to wild type, SMP30-knockout and SOD1-knockout mice [3618]. Overexpression of human SOD1 in transgenic mice results in neurodegenerative changes [663]. In humans, mutations in SOD1 have been associated with amyotrophic lateral sclerosis [671]. A role for SOD1 in human ageing, while not impossible, remains to be determined.

Cytogenetic information

Cytogenetic band
21q22.11
Location
31,659,622 bp to 31,668,930 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000187; activation of MAPK activity
GO:0000302; response to reactive oxygen species
GO:0000303; response to superoxide
GO:0001541; ovarian follicle development
GO:0001819; positive regulation of cytokine production
GO:0001890; placenta development
GO:0001895; retina homeostasis
GO:0001975; response to amphetamine
GO:0002262; myeloid cell homeostasis
GO:0002576; platelet degranulation
GO:0006749; glutathione metabolic process
And 50 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005758; mitochondrial intermembrane space
GO:0005759; mitochondrial matrix
GO:0005764; lysosome
GO:0005777; peroxisome
GO:0005829; cytosol
And 11 more GO terms
Function: GO:0004784; superoxide dismutase activity
GO:0005507; copper ion binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0030346; protein phosphatase 2B binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0048365; Rac GTPase binding
GO:0051087; chaperone binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TXN, PIN1, BCL2, CAT, SOD2, SOD1, PRDX1, RGN, HSPA9, PCMT1, HSPA8, RAE1, STUB1, GPX4, TRAP1
STRING interaction network
Protein-Protein network diagram for SOD1

Retrieve sequences for SOD1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
sod-5
Danio rerio
sod1
Drosophila melanogaster
Sod
Mus musculus
Sod1
Rattus norvegicus
Sod1
Saccharomyces cerevisiae
SOD1
Schizosaccharomyces pombe
sod1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
  • A homolog of this gene for Drosophila melanogaster is present as Sod
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
LongevityMap
  • This gene is present as SOD1
CellAge
  • This gene is present as SOD1

Selected references

External links

EPD
HS_SOD1
ORF Accession
NM_000454
CDS Accession
NP_000445
OMIM
147450
HPRD
00937
Ensembl
SOD1
UniProt/Swiss-Prot
SODC_HUMAN
GeneCards
SOD1
Entrez Gene
6647
UniGene
443914
GenAtlas
SOD1
Internet
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