GenAge entry for MSRA (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 127)

HGNC symbol
MSRA 
Aliases
 
Common name
methionine sulfoxide reductase A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

MSRA repairs damage resulting from oxidative stress. Results from invertebrates suggest a role for MSRA in ageing. Overexpression of a MSRA homologue in fruit flies extends lifespan [42]. Disruption of MSRA in mice decreases longevity and, albeit not proven, might accelerate ageing [43]. In humans, MSRA has been associated with age-related diseases, such as Alzheimer's disease [978]. Therefore, MSRA could be involved in human ageing.

Cytogenetic information

Cytogenetic band
8p23.1
Location
10,054,269 bp to 10,428,891 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006464; cellular protein modification process
GO:0006555; methionine metabolic process
GO:0006979; response to oxidative stress
GO:0030091; protein repair
GO:0055114; oxidation-reduction process
Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0016020; membrane
GO:0070062; extracellular exosome
Function: GO:0008113; peptide-methionine (S)-S-oxide reductase activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for MSRA

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
msra-1
Danio rerio
si:dkey-221h15.1
Drosophila melanogaster
Eip71CD
Mus musculus
Msra
Rattus norvegicus
Msra
Saccharomyces cerevisiae
MXR1
Schizosaccharomyces pombe
mxr1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Eip71CD
  • A homolog of this gene for Mus musculus is present as Msra
  • A homolog of this gene for Saccharomyces cerevisiae is present as MXR1

Selected references

External links

EPD
ORF Accession
NM_012331
CDS Accession
NP_036463
OMIM
601250
HPRD
03152
Ensembl
MSRA
UniProt/Swiss-Prot
MSRA_HUMAN
GeneCards
MSRA
Entrez Gene
4482
UniGene
490981
GenAtlas
MSRA
Internet
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