GenAge entry for POLD1 (Homo sapiens)

Gene name (HAGRID: 118)

HGNC symbol
POLD1 
Aliases
CDC2; POLD 
Common name
polymerase (DNA directed), delta 1, catalytic subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

POLD1 is mostly involved in DNA synthesis, and probably it also functions in DNA repair [920]. Mice with a proofreading-deficient version of POLD1 have a higher cancer incidence [917]. POLD1 has also been associated with WRN [922]. There is no direct evidence linking POLD1 to human ageing, but it should be considered a suspect gene.

Cytogenetic information

Cytogenetic band
19q13.3
Location
50,384,323 bp to 50,418,018 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006287; base-excision repair, gap-filling
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006298; mismatch repair
And 8 more GO terms
Cellular component: GO:0000109; nucleotide-excision repair complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016020; membrane
GO:0016235; aggresome
GO:0043625; delta DNA polymerase complex
Function: GO:0000166; nucleotide binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0005515; protein binding
GO:0008296; 3'-5'-exodeoxyribonuclease activity
GO:0019899; enzyme binding
GO:0046872; metal ion binding
GO:0051539; 4 iron, 4 sulfur cluster binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
MYC, RPA1, ERCC6, PCNA, TERF2, ATR, SPRTN
STRING interaction network
Protein-Protein network diagram for POLD1

Retrieve sequences for POLD1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
F10C2.4
Danio rerio
pold1
Drosophila melanogaster
DNApol-delta
Mus musculus
Pold1
Rattus norvegicus
Pold1
Saccharomyces cerevisiae
POL3
Schizosaccharomyces pombe
pol3

In other databases

LongevityMap
  • This gene is present as POLD1

Selected references

External links

EPD
ORF Accession
NM_002691
CDS Accession
NP_002682
OMIM
174761
HPRD
08882
Ensembl
POLD1
UniProt/Swiss-Prot
DPOD1_HUMAN
GeneCards
POLD1
Entrez Gene
5424
UniGene
279413
GenAtlas
POLD1
Internet
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