GenAge entry for FAS (Homo sapiens)

Gene name (HAGRID: 115)

HGNC symbol
FAS 
Aliases
CD95; APO-1; FAS1; APT1; TNFRSF6 
Common name
Fas cell surface death receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

FAS encodes multiple transcripts involved in apoptosis and development. It is also related to cancer progression. The expression level of FAS changes during ageing [937], and there are some results correlating FAS with age-related changes [1170]. Nonetheless, polymorphisms in human FAS have not been associated with human longevity [935].

Cytogenetic information

Cytogenetic band
10q24.1
Location
88,990,531 bp to 89,015,785 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002377; immunoglobulin production
GO:0003014; renal system process
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924; activation-induced cell death of T cells
GO:0006925; inflammatory cell apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007420; brain development
And 36 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0009986; cell surface
GO:0031264; death-inducing signaling complex
GO:0031265; CD95 death-inducing signaling complex
GO:0043005; neuron projection
GO:0045121; membrane raft
And 2 more GO terms
Function: GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0019900; kinase binding
GO:0042802; identical protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
UBE2I, TNF, PML, PRKCA, FAS, RB1, MAPK8, MAP3K5, EEF1A1, SUMO1, CTNNB1, TP63, SQSTM1
STRING interaction network
Protein-Protein network diagram for FAS

Retrieve sequences for FAS

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
fas
Mus musculus
Fas
Rattus norvegicus
Fas

In other databases

LongevityMap
  • This gene is present as FAS

Selected references

External links

EPD
ORF Accession
NM_000043
CDS Accession
NP_000034
OMIM
134637
HPRD
00609
Ensembl
FAS
UniProt/Swiss-Prot
TNR6_HUMAN
GeneCards
FAS
Entrez Gene
355
UniGene
244139
GenAtlas
FAS
Internet
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