GenAge entry for PCNA (Homo sapiens)

Gene name (HAGRID: 113)

HGNC symbol
PCNA 
Aliases
 
Common name
proliferating cell nuclear antigen 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

PCNA is an important player in DNA replication and, probably, in DNA repair. It has been associated with pathways suspect of being involved in human ageing, and it interacts with WRN [440]. PCNA levels have also been linked to cellular proliferation in aged rats [581]. In humans, a hypomorphic PCNA mutation causes a syndrome displaying a neurodegenerative phenotype including short stature, hearing loss, premature aging, telangiectasia, neurodegeneration, and photosensitivity. Additionally, patient cells exhibit abnormalities in response to UV irradiation [3604]. Therefore, it is possible that PCNA influences human ageing even though more detailed studies are necessary to prove such hypothesis.

Cytogenetic information

Cytogenetic band
20pter-p12
Location
5,114,953 bp to 5,120,001 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006272; leading strand elongation
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006298; mismatch repair
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
And 23 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005657; replication fork
GO:0005663; DNA replication factor C complex
GO:0005737; cytoplasm
GO:0005813; centrosome
GO:0030894; replisome
GO:0043596; nuclear replication fork
GO:0043626; PCNA complex
GO:0070062; extracellular exosome
And 2 more GO terms
Function: GO:0000701; purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0030331; estrogen receptor binding
GO:0030337; DNA polymerase processivity factor activity
GO:0030971; receptor tyrosine kinase binding
GO:0032139; dinucleotide insertion or deletion binding
GO:0032405; MutLalpha complex binding
GO:0035035; histone acetyltransferase binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ERCC8, WRN, EGFR, PARP1, BRCA1, CREBBP, RPA1, ABL1, BRCA2, TOP1, RAD51, ERCC6, EP300, PRKDC, ERCC5, XRCC5, PCNA, FEN1, POLD1, XRCC6, FOXO3, HDAC1, CCNA2, EEF1A1, ATF2, APEX1, MDM2, POLA1, CDKN2A, POLB, MLH1, CDKN1A, SPRTN
STRING interaction network
Protein-Protein network diagram for PCNA

Retrieve sequences for PCNA

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pcn-1
Danio rerio
pcna
Drosophila melanogaster
mus209
Mus musculus
Pcna-ps2
Rattus norvegicus
Pcna
Saccharomyces cerevisiae
POL30
Schizosaccharomyces pombe
pcn1

In other databases

LongevityMap
  • This gene is present as PCNA

Selected references

External links

EPD
ORF Accession
NM_182649
CDS Accession
NP_872590
OMIM
176740
HPRD
01456
Ensembl
PCNA
UniProt/Swiss-Prot
PCNA_HUMAN
GeneCards
PCNA
Entrez Gene
5111
UniGene
147433
GenAtlas
PCNA
Internet
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