GenAge entry for CAT (Homo sapiens)

Gene name (HAGRID: 0107)

HGNC symbol: CAT
Aliases
Common name: catalase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [0039], but the same effects are not witnessed in long-lived strains [0040]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Cytogenetic information

Cytogenetic band: 11p13
Location: 34,417,068 bp to 34,450,183 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser

Protein information

Gene Ontology

Process:

GO:0055114; oxidation reduction

Function:

GO:0005506; iron ion binding
GO:0046872; metal ion binding

Cellular component:

GO:0005778; peroxisomal membrane

Protein interactions and network

Protein-protein interacting partners in GenAge: ATM
IDG: Display interactions using the IGD
STRING interaction network

Retrieve sequences for CAT

ORF: ORF
CDS: CDS

Homologues in model organisms

Bos taurus: CATA_BOVIN
Caenorhabditis elegans: ctl-1
Caenorhabditis elegans: ctl-2
Caenorhabditis elegans: ctl-3
Drosophila melanogaster: Cat
Drosophila melanogaster: CG9314
Mus musculus: Cat
Pan troglodytes: CAT
Rattus norvegicus: Cat
Saccharomyces cerevisiae: CTA1

In other databases

GenAge

This gene has the homolog Cat in GenAge for Drosophila melanogaster
This gene has the homolog Cat in GenAge for Mus musculus

AnAge

This species has an entry in AnAge

Selected references

[1964] Lee et al. (2010) Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance., PubMed
[2100] Treuting et al. (2008) Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria., PubMed
[1930] Alcendor et al. (2007) Sirt1 regulates aging and resistance to oxidative stress in the heart, PubMed
[1941] Wu et al. (2007) Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage, PubMed
[1637] Ehrenbrink et al. (2006) Antioxidant enzymes activities and protein damage in rat brain of both sexes, PubMed
[1636] Sinitsyna et al. (2006) Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals, PubMed
[1635] Alvarez-Garcia et al. (2006) Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age, PubMed
[1630] Martinez-Romero et al. (2006) Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex, PubMed
[1632] Kakarla et al. (2005) Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system, PubMed
[1631] Siqueira et al. (2005) Total antioxidant capacity is impaired in different structures from aged rat brain, PubMed
[1583] Greer and Brunet (2005) FOXO transcription factors at the interface between longevity and tumor suppression, PubMed
[1628] Marzani et al. (2005) Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles, PubMed
[1538] Wolf et al. (2005) Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence, PubMed
[1781] Bayne et al. (2005) Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila, PubMed
[1335] Schriner et al. (2005) Extension of murine lifespan by overexpression of catalase targeted to mitochondria, PubMed
[1119] Martin and Friedman (2004) Ticking fast or ticking slow, through shc must you go?, PubMed
[1107] Quarrie and Riabowol (2004) Murine models of life span extension, PubMed
[1143] Klichko et al. (2004) Profiling catalase gene expression in Drosophila melanogaster during development and aging, PubMed
[1823] Hussain et al. (2004) p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis, PubMed
[1654] Petriv and Rachubinski (2004) Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans, PubMed
[0560] Liu et al. (2003) Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics, PubMed
[0561] Casado and Lopez-Fernandez (2003) Age-correlated changes of the erythrocyte catalase activity in the Spanish population, PubMed
[0040] Orr et al. (2003) Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster, PubMed
[0563] Mockett et al. (2003) Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity, PubMed
[1244] Jiang et al. (2001) A polymorphism in the promoter region of catalase is associated with blood pressure levels, PubMed
[0911] Hall et al. (2001) Aging lowers steady-state antioxidant enzyme and stress protein expression in primary hepatocytes, PubMed
[1243] Forsberg et al. (2001) A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels, PubMed
[0205] Goth and Eaton (2000) Hereditary catalase deficiencies and increased risk of diabetes, PubMed
[0047] Schriner et al. (2000) Levels of dna damage are unaltered in mice overexpressing human catalase in nuclei, PubMed
[0204] Melov et al. (2000) Extension of life-span with superoxide dismutase/catalase mimetics, PubMed
[0564] Brown-Borg and Rakoczy (2000) Catalase expression in delayed and premature aging mouse models, PubMed
[0994] Watters et al. (1999) Localization of a portion of extranuclear ATM to peroxisomes, PubMed
[1246] Keogh et al. (1996) Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages, PubMed
[0039] Orr and Sohal (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster, PubMed
[0567] Ogata (1991) Acatalasemia, PubMed
[0566] Wen et al. (1990) Molecular analysis of human acatalasemia: identification of a splicing mutation, PubMed
[0565] Shaffer and Preston (1990) Molecular analysis of an acatalasemic mouse mutant, PubMed