GenAge entry for CAT (Homo sapiens)

Gene name (HAGRID: 0107)

Potential relevance to the human ageing process

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [0039], but the same effects are not witnessed in long-lived strains [0040]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Cytogenetic information

Display region using the UCSC Genome Browser

Protein information

GO:0055114; oxidation reduction; Process

GO:0005506; iron ion binding; Function
GO:0046872; metal ion binding; Function

GO:0005778; peroxisomal membrane; Cellular component

Protein-protein interactions

Display interactions using the IGD

Retrieve sequences for CAT

Homologues in model organisms

HomoloGene (55514)

Selected references

[1930] Alcendor et al. (2007), Sirt1 regulates aging and resistance to oxidative stress in the heart, PubMed
[1941] Wu et al. (2007), Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage, PubMed
[1637] Ehrenbrink et al. (2006), Antioxidant enzymes activities and protein damage in rat brain of both sexes, PubMed
[1636] Sinitsyna et al. (2006), Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals, PubMed
[1635] Alvarez-Garcia et al. (2006), Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age, PubMed
[1630] Martinez-Romero et al. (2006), Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex, PubMed
[1632] Kakarla et al. (2005), Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system, PubMed
[1631] Siqueira et al. (2005), Total antioxidant capacity is impaired in different structures from aged rat brain, PubMed
[1583] Greer and Brunet (2005), FOXO transcription factors at the interface between longevity and tumor suppression, PubMed
[1628] Marzani et al. (2005), Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles, PubMed
[1538] Wolf et al. (2005), Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence, PubMed
[1781] Bayne et al. (2005), Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila, PubMed
[1335] Schriner et al. (2005), Extension of murine lifespan by overexpression of catalase targeted to mitochondria, PubMed
[1119] Martin and Friedman (2004), Ticking fast or ticking slow, through shc must you go?, PubMed
[1107] Quarrie and Riabowol (2004), Murine models of life span extension, PubMed
[1143] Klichko et al. (2004), Profiling catalase gene expression in Drosophila melanogaster during development and aging, PubMed
[1823] Hussain et al. (2004), p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis, PubMed
[1654] Petriv and Rachubinski (2004), Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans, PubMed
[0560] Liu et al. (2003), Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics, PubMed
[0561] Casado and Lopez-Fernandez (2003), Age-correlated changes of the erythrocyte catalase activity in the Spanish population, PubMed
[0040] Orr et al. (2003), Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster, PubMed
[0563] Mockett et al. (2003), Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity, PubMed
[1244] Jiang et al. (2001), A polymorphism in the promoter region of catalase is associated with blood pressure levels, PubMed
[0911] Hall et al. (2001), Aging lowers steady-state antioxidant enzyme and stress protein expression in primary hepatocytes, PubMed
[1243] Forsberg et al. (2001), A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels, PubMed
[0205] Goth and Eaton (2000), Hereditary catalase deficiencies and increased risk of diabetes, PubMed
[0047] Schriner et al. (2000), Levels of dna damage are unaltered in mice overexpressing human catalase in nuclei, PubMed
[0204] Melov et al. (2000), Extension of life-span with superoxide dismutase/catalase mimetics, PubMed
[0564] Brown-Borg and Rakoczy (2000), Catalase expression in delayed and premature aging mouse models, PubMed
[0994] Watters et al. (1999), Localization of a portion of extranuclear ATM to peroxisomes, PubMed
[1246] Keogh et al. (1996), Expression of hydrogen peroxide and glutathione metabolizing enzymes in human skin fibroblasts derived from donors of different ages, PubMed
[0039] Orr and Sohal (1994), Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster, PubMed
[0567] Ogata (1991), Acatalasemia, PubMed
[0566] Wen et al. (1990), Molecular analysis of human acatalasemia: identification of a splicing mutation, PubMed
[0565] Shaffer and Preston (1990), Molecular analysis of an acatalasemic mouse mutant, PubMed

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