GenAge entry for CAT (Homo sapiens)

Gene name (HAGRID: 107)

HGNC symbol
CAT 
Aliases
 
Common name
catalase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.

Cytogenetic information

Cytogenetic band
11p13
Location
34,417,068 bp to 34,450,183 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0001666; response to hypoxia
GO:0006144; purine nucleobase metabolic process
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0008203; cholesterol metabolic process
GO:0009060; aerobic respiration
GO:0009650; UV protection
GO:0014068; positive regulation of phosphatidylinositol 3-kinase cascade
GO:0020027; hemoglobin metabolic process
GO:0032088; negative regulation of NF-kappaB transcription factor activity
And 13 more GO terms
Cellular component: GO:0005758; mitochondrial intermembrane space
GO:0005764; lysosome
GO:0005777; peroxisome
GO:0005778; peroxisomal membrane
GO:0005782; peroxisomal matrix
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
Function: GO:0004046; aminoacylase activity
GO:0004096; catalase activity
GO:0005102; receptor binding
GO:0016209; antioxidant activity
GO:0016684; oxidoreductase activity, acting on peroxide as acceptor
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050661; NADP binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ATM
STRING interaction network
Protein-Protein network diagram for CAT

Retrieve sequences for CAT

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ctl-3
Drosophila melanogaster
CG9314
Danio rerio
cat
Mus musculus
Cat
Rattus norvegicus
Cat
Saccharomyces cerevisiae
CTA1
Schizosaccharomyces pombe
cta1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cat
  • A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
LongevityMap
  • This gene is present as CAT

Selected references

External links

EPD
ORF Accession
NM_001752
CDS Accession
NP_001743
OMIM
115500
HPRD
00282
Ensembl
CAT
UniProt/Swiss-Prot
CATA_HUMAN
GeneCards
CAT
Entrez Gene
847
UniGene
502302
GenAtlas
CAT
Internet
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