| Description | AKT1 is a protein kinase that is also considered an oncogene. It appears to mediate insulin's (INS) actions and be involved in the signal transduction of growth factors such as IGF1. AKT1 also impacts on cell survival and development, and it activates NFKB1 [0333]. AKT1 null mice are smaller but viable and more susceptible to genotoxic stress and apoptosis [0327].
In roundworms, two AKT1 homologues play a role in insulin-like signalling, influence dauer formation, and might impact on lifespan [0948]. AKT1 also appears to play a role in cellular senescence [1660]. Some evidence suggests AKT1 may play a role in ageing through its impact on energy metabolism [0823], but its role, if any, on human ageing remains elusive. |
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