GenAge entry for MAPK8 (Homo sapiens)

Gene name (HAGRID: 163)

HGNC symbol: MAPK8
Aliases: JNK; JNK1; SAPK1; PRKM8
Common name: mitogen-activated protein kinase 8

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: MAPK8, also known as JNK1, encodes many transcripts and is an important player in stress response. In invertebrates, there is evidence linking JNK signalling to ageing. Fruit flies with mutations that augment JNK signalling live longer [212]. Overexpression of JNK in roundworms also increases lifespan [60]. Changes in JNK1 with age have been reported in rat hepatocytes [768]. MAPK8-null mice showed defective T cell differentiation [761]. Mice without MAPK8 and MAPK9 die at embryonic stages [1715]. In mouse models of obesity, absence of MAPK8 decreased adiposity and improved insulin (INS) sensitivity [765]. Although MAPK8 could play a role in ageing-related diseases, further research is needed to determine how MAPK8 is related to human ageing.

Cytogenetic information

Cytogenetic band: 10q11.22
Location: 48,401,612 bp to 48,439,359 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007254; JNK cascade
GO:0007258; JUN phosphorylation
GO:0009411; response to UV
GO:0010628; positive regulation of gene expression
GO:0016241; regulation of macroautophagy
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0031063; regulation of histone deacetylation
GO:0031281; positive regulation of cyclase activity
GO:0032091; negative regulation of protein binding
GO:0032880; regulation of protein localization
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042752; regulation of circadian rhythm
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0048511; rhythmic process
GO:0051090; regulation of sequence-specific DNA binding transcription factor activity
GO:0051247; positive regulation of protein metabolic process
GO:0071222; cellular response to lipopolysaccharide
GO:0071260; cellular response to mechanical stimulus
GO:0090045; positive regulation of deacetylase activity
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol

Function:

GO:0004674; protein serine/threonine kinase activity
GO:0004705; JUN kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0019899; enzyme binding
GO:0035033; histone deacetylase regulator activity
GO:0042826; histone deacetylase binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, STAT3, IRS1, AKT1, HRAS, MYC, EGFR, JUND, BCL2, PDPK1, CEBPA, EP300, PRKDC, FAS, RB1, HSF1, APP, SNCG, SIRT1, HDAC1, GSTP1, MAPK8, YWHAZ, SP1, JUN, MAPK9, ATF2, HSPA8, MAPT, H2AFX, MTOR, CTNNB1, CDKN2A, CDC42, NFE2L2, CDKN1A
STRING interaction network

Retrieve sequences for MAPK8

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: jnk-1
Danio rerio: mapk8a
Danio rerio: mapk8b
Drosophila melanogaster: bsk
Mus musculus: Mapk8
Rattus norvegicus: Mapk8
Saccharomyces cerevisiae: HOG1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as jnk-1
A homolog of this gene for Drosophila melanogaster is present as bsk