GenAge entry for BAX (Homo sapiens)

Gene name (HAGRID: 119)

HGNC symbol: BAX
Aliases: BCL2L4
Common name: BCL2-associated X protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: An important player in apoptosis, BAX encodes multiple transcripts and has been linked to development, cancer, and age-related changes in apoptosis [600]. Inactivation of BAX in mice extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. It did not extend lifespan [1927]. Changes in apoptotic proteins like BAX could also contribute to ageing-associated atrophy in the skeletal muscle of rats [1639]. It is not known how these processes are related to human ageing, but a role of BAX in human ageing is a possibility.

Cytogenetic information

Cytogenetic band: 19q13.3-q1
Location: 48,954,860 bp to 48,961,262 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001541; ovarian follicle development
GO:0001764; neuron migration
GO:0001777; T cell homeostatic proliferation
GO:0001782; B cell homeostasis
GO:0001783; B cell apoptotic process
GO:0001822; kidney development
GO:0001836; release of cytochrome c from mitochondria
GO:0001844; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974; blood vessel remodeling
GO:0002262; myeloid cell homeostasis
GO:0002352; B cell negative selection

And 78 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005635; nuclear envelope GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005741; mitochondrial outer membrane GO:0005757; mitochondrial permeability transition pore complex GO:0005783; endoplasmic reticulum GO:0005789; endoplasmic reticulum membrane GO:0005829; cytosol GO:0016020; membrane GO:0046930; pore complex
	And 4 more GO terms

Function:

GO:0005515; protein binding
GO:0008289; lipid binding
GO:0015267; channel activity
GO:0030544; Hsp70 protein binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046982; protein heterodimerization activity
GO:0051087; chaperone binding
GO:0051434; BH3 domain binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, BCL2, VCP, ERCC6, XRCC5, XRCC6, BAX, PRDX1, HSPD1, CLU, KCNA3, BAK1
STRING interaction network

Retrieve sequences for BAX

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: baxb
Danio rerio: baxa
Danio rerio: BX511080.1
Danio rerio: baxa
Mus musculus: Bax
Rattus norvegicus: Bax

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Bax

LongevityMap

This gene is present as BAX