GenAge entry for APOC3 (Homo sapiens)

Gene name (HAGRID: 102)

HGNC symbol
APOC3 
Aliases
 
Common name
apolipoprotein C-III 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

APOC3 is involved in fat metabolism and may delay the catabolism of triglyceride-rich particles. Changes in APOC3 expression levels have been reported in aged mice [1754]. Results from mice suggest that FOXO1 may regulate the expression of APOC3 [1743]. Polymorphisms in the human APOC3 gene and promoter have been associated with lipoprotein profile, cardiovascular health, insulin (INS) sensitivity, and longevity [1756]. Therefore, APOC3 may impact on some age-related diseases, though its exact role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
11q23.3
Location
116,829,908 bp to 116,833,071 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001523; retinoid metabolic process
GO:0006641; triglyceride metabolic process
GO:0007186; G-protein coupled receptor signaling pathway
GO:0010897; negative regulation of triglyceride catabolic process
GO:0010903; negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916; negative regulation of very-low-density lipoprotein particle clearance
GO:0010987; negative regulation of high-density lipoprotein particle clearance
GO:0010989; negative regulation of low-density lipoprotein particle clearance
GO:0019433; triglyceride catabolic process
GO:0032489; regulation of Cdc42 protein signal transduction
GO:0033344; cholesterol efflux
GO:0033700; phospholipid efflux
GO:0034375; high-density lipoprotein particle remodeling
GO:0034379; very-low-density lipoprotein particle assembly
GO:0034382; chylomicron remnant clearance
GO:0042157; lipoprotein metabolic process
GO:0042632; cholesterol homeostasis
GO:0043691; reverse cholesterol transport
GO:0045717; negative regulation of fatty acid biosynthetic process
GO:0045833; negative regulation of lipid metabolic process
GO:0048261; negative regulation of receptor-mediated endocytosis
GO:0050995; negative regulation of lipid catabolic process
GO:0051005; negative regulation of lipoprotein lipase activity
GO:0060621; negative regulation of cholesterol import
GO:0070328; triglyceride homeostasis
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005769; early endosome
GO:0034361; very-low-density lipoprotein particle
GO:0034363; intermediate-density lipoprotein particle
GO:0034366; spherical high-density lipoprotein particle
GO:0042627; chylomicron
GO:0070062; extracellular exosome
Function: GO:0005543; phospholipid binding
GO:0015485; cholesterol binding
GO:0030234; enzyme regulator activity
GO:0055102; lipase inhibitor activity
GO:0070653; high-density lipoprotein particle receptor binding
Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for APOC3

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Apoc3
Rattus norvegicus
Apoc3

In other databases

LongevityMap
  • This gene is present as APOC3

Selected references

External links

EPD
HS_APOC3
ORF Accession
NM_000040
CDS Accession
NP_000031
OMIM
107720
HPRD
00132
Ensembl
APOC3
UniProt/Swiss-Prot
APOC3_HUMAN
GeneCards
APOC3
Entrez Gene
345
GenAtlas
APOC3
Internet
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