GenAge entry for NDI1 (Saccharomyces cerevisiae)
Gene information (ID: 457)
- Symbol
- NDI1
- Name
- NADH-ubiquinone reductase (H(+)-translocating) NDI1
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Mitochondrial electron transport chain
Potential relevance to longevity and/or ageing
- Observations
- Targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity.
- % change in avg or median lifespan
- Average lifespan is 7-21% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Expression of Ndi1 in adipose tissue resulted in shortened lifespan in both male and female flies.
- % change in avg or median lifespan
- Average lifespan is 9-22% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Expression of yeast Ndi1 in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends median lifespan. This effect was consistently seen in fly females, but depends on the conditions and expression system in males. Additionally to the lifespan effect, flies expressing Ndi1 have an increased feeding behavior and display weight gain.
- % change in avg or median lifespan
- Median lifespan is up to 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Deletion results in chronological lifespan extension.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
In other databases
- GenDR gene manipulations
- This gene is present as NDI1
Homologs in other organisms
No homologs found
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (854919)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar